GDIR1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDIR1_RAT
• UniProt AC: Q5XI73
• Protein Name: Rho GDP-dissociation inhibitor 1 {ECO:0000250|UniProtKB:P19803}
• Gene Name: Arhgdia {ECO:0000312|RGD:1359547}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 204
• Subcellular Localization: Cytoplasm .
• Protein Description: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1..
• Protein Sequence: MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRVAVSADPNVPNVIVTRLTLVCSTAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKIDKTDYMVGSYGPRAEEYEFLTPMEEAPKGMLARGSYNIKSRFTDDDKTDHLSWEWNLTIKKEWKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEQEPTAE ------CCCCCCCHH	27.46	-
7	Phosphorylation	-MAEQEPTAEQLAQI -CCCCCCCHHHHHHH	41.91	23984901
24	Phosphorylation	ENEEDEHSVNYKPPA HCCCCCCCCCCCCCC	15.26	27097102
27	Phosphorylation	EDEHSVNYKPPAQKS CCCCCCCCCCCCHHH	23.79	23984901
28	Acetylation	DEHSVNYKPPAQKSI CCCCCCCCCCCHHHH	39.04	22902405
34	Phosphorylation	YKPPAQKSIQEIQEL CCCCCHHHHHHHHHH	19.88	20472934
43	Succinylation	QEIQELDKDDESLRK HHHHHHCCCCHHHHH	78.63	26843850
43	Acetylation	QEIQELDKDDESLRK HHHHHHCCCCHHHHH	78.63	22902405
47	Phosphorylation	ELDKDDESLRKYKEA HHCCCCHHHHHHHHH	40.23	25532521
50	Methylation	KDDESLRKYKEALLG CCCHHHHHHHHHHHH	67.00	-
50	"N6,N6-dimethyllysine"	KDDESLRKYKEALLG CCCHHHHHHHHHHHH	67.00	-
52	"N6,N6-dimethyllysine"	DESLRKYKEALLGRV CHHHHHHHHHHHHCE	39.28	-
52	Methylation	DESLRKYKEALLGRV CHHHHHHHHHHHHCE	39.28	-
52	Acetylation	DESLRKYKEALLGRV CHHHHHHHHHHHHCE	39.28	22902405
62	Phosphorylation	LLGRVAVSADPNVPN HHHCEECCCCCCCCC	19.74	29779826
99	Acetylation	GDLESFKKQSFVLKE CCHHHHHHEEEEEEC	49.52	22902405
101	Phosphorylation	LESFKKQSFVLKEGV HHHHHHEEEEEECCE	26.63	19103160
105	Acetylation	KKQSFVLKEGVEYRI HHEEEEEECCEEEEE	47.31	22902405
111	Methylation	LKEGVEYRIKISFRV EECCEEEEEEEEEEE	15.37	166183
111	Dimethylation	LKEGVEYRIKISFRV EECCEEEEEEEEEEE	15.37	-
113	Acetylation	EGVEYRIKISFRVNR CCEEEEEEEEEEECH	24.25	22902405
127	Acetylation	REIVSGMKYIQHTYR HHHHCCCCHHHHHHC	42.60	22902405
133	Phosphorylation	MKYIQHTYRKGVKID CCHHHHHHCCCCCCC	14.27	-
138	Acetylation	HTYRKGVKIDKTDYM HHHCCCCCCCCCCCC	54.58	22902405
141	Ubiquitination	RKGVKIDKTDYMVGS CCCCCCCCCCCCCCC	46.93	-
141	Succinylation	RKGVKIDKTDYMVGS CCCCCCCCCCCCCCC	46.93	-
141	Acetylation	RKGVKIDKTDYMVGS CCCCCCCCCCCCCCC	46.93	22902405
141	Succinylation	RKGVKIDKTDYMVGS CCCCCCCCCCCCCCC	46.93	-
144	Phosphorylation	VKIDKTDYMVGSYGP CCCCCCCCCCCCCCC	10.03	22817900
148	Phosphorylation	KTDYMVGSYGPRAEE CCCCCCCCCCCCHHH	18.59	22817900
149	Phosphorylation	TDYMVGSYGPRAEEY CCCCCCCCCCCHHHE	25.81	25575281
152	Methylation	MVGSYGPRAEEYEFL CCCCCCCCHHHEEEE	50.71	166189
152	Dimethylation	MVGSYGPRAEEYEFL CCCCCCCCHHHEEEE	50.71	-
160	Phosphorylation	AEEYEFLTPMEEAPK HHHEEEECCHHHCCC	26.38	23984901
167	Acetylation	TPMEEAPKGMLARGS CCHHHCCCCCCCCCC	65.09	22902405
174	Phosphorylation	KGMLARGSYNIKSRF CCCCCCCCEECCCCC	14.95	30181290
178	Acetylation	ARGSYNIKSRFTDDD CCCCEECCCCCCCCC	31.76	25786129
180	Dimethylation	GSYNIKSRFTDDDKT CCEECCCCCCCCCCC	33.22	-
180	Methylation	GSYNIKSRFTDDDKT CCEECCCCCCCCCCC	33.22	166195

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
34	S	Phosphorylation	Kinase	PAK2	Q13177	PSP
101	S	Phosphorylation	Kinase	PAK2	Q13177	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDIR1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDIR1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GDIR1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.