NFAT5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NFAT5_RAT
• UniProt AC: D3ZGB1
• Protein Name: Nuclear factor of activated T-cells 5
• Gene Name: Nfat5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1548
• Subcellular Localization: Nucleus . Cytoplasm . Nuclear distribution increases under hypertonic conditions.
• Protein Description: Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes..
• Protein Sequence: MPSDFISLLSADLDLESPKSLYSRDSLKLHPSQNFHRAGLLEESVYDLLPKELQLPPPRETSAASMSQTSGGEAGSPPPAVVAADASSAPSSSMGGACSSFTTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVSEKQLTGNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLDSQKGTGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSSNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNITRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPAAGALSVNVKKEISSPARPCSFEEALKAMKTTGCNVDKVTILPNALITPLISSSMIKTEDVTPMEVTSEKRSSPIFQTTKTVGSTQQTLETISNIAGNASFSSPSSSHLSPENENQQQLQPKAYNPETLTTIQTQDISQPGTFPAVSASSQLPSSDALLQQAAQFQTRDAQSRDTMQSDSVVNLSQLTEAPQQQQSPLQEQAQIPSNIFPSPNSVSQLQSTIQQLQAGSFTGSTASGSNGSVDLVQQVLEAQQQLSSVLFSTPDGNENVQEQLNADIFQVSQIQNSVSPGMFSSTESAVHTRPDNLLPGRADSVHQQTENTLSSQQQQQQQQQQQQQQQVIESSAAMVMEMQQSICQAAAQIQSELFPSAASANGSLQQSPVYQQPSHMMSALPTSEDMQMQCELFSSPPAVSGNETSTTTTPQVATPGSTMFQPPNSGDGEETGAQAKQIQSSVFQTMVQMQHSGDSQPQVNLFSSTKNIMSVQSNGTQQQGNSLFQQGSEMLSLQSGSFLQQSSHSQAQLFHPQNPIADAQSLSQETQGPMFHSANPIVHSQTSTASSEQLQPSMFHSQSTIAVLQGSSVPQDQQSPNIYLSQSSISNLQTNTVAQEEQISFFSAQNSISPLQSTSNTEQQAAFQQQPPISHIQTPLLSQEQAQPSQQGLFQPQVALGSLPANPMPQNQQGPIFQTQRPIVGMQSNSPSQEQQQQQQQQQQQQQQQQQQSILFSNQNAMATMASQKQPPPNMIFSPNQNPMASQEQQNQSIFHQQSNMAPMNQEQQPMQFQNQPTVSSLQNPGPTPSESPQTSLFHSSPQIQLVQGSPSSQEQQVTLFLSPASMSALQTSINQPDMQQSPLYSPQNNIPGIQGSTSSPQPQAALFHNTTGGTINQLQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPEQLMAINQPGQPQNEGQSSVTTLLSQQMPESAPLASSVNNSQNMEKIDLLVSLQSQGNNLTGSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSDFISLLS -----CCHHHHHHHH		27097102
7	Phosphorylation	-MPSDFISLLSADLD -CCHHHHHHHHCCCC		27097102
10	Phosphorylation	SDFISLLSADLDLES HHHHHHHHCCCCCCC		27097102
124	Phosphorylation	SKAMQVESCSSAVGV CCCCCEEECHHCCCC		27097102
126	Phosphorylation	AMQVESCSSAVGVSN CCCEEECHHCCCCCC		27097102
127	Phosphorylation	MQVESCSSAVGVSNR CCEEECHHCCCCCCC		27097102
137	Phosphorylation	GVSNRGVSEKQLTGN CCCCCCCCHHHCCCC		-
139	Acetylation	SNRGVSEKQLTGNTV CCCCCCHHHCCCCCC		-
151	Phosphorylation	NTVQQHPSTPKRHTV CCCCCCCCCCCCCEE		-
152	Phosphorylation	TVQQHPSTPKRHTVL CCCCCCCCCCCCEEE		-
160	Phosphorylation	PKRHTVLYISPPPED CCCCEEEEECCCHHH		-
162	Phosphorylation	RHTVLYISPPPEDLL CCEEEEECCCHHHHC		22108457
172	Phosphorylation	PEDLLDNSRMSCQDE HHHHCCCCCCCCCCC		-
246	Phosphorylation	MDIFDADSAKAPHYV CCCCCCCCCCCCCEE		28432305
367	Phosphorylation	FYQACRVTGRNTTPC EEECEEEECCCCCCC		25575281
371	Phosphorylation	CRVTGRNTTPCKEVD EEEECCCCCCCEEEC		25575281
372	Phosphorylation	RVTGRNTTPCKEVDI EEECCCCCCCEEECC		25575281
576	Phosphorylation	VNVKKEISSPARPCS EEEEHHCCCCCCCCC		28432305
577	Phosphorylation	NVKKEISSPARPCSF EEEHHCCCCCCCCCH		22108457
583	Phosphorylation	SSPARPCSFEEALKA CCCCCCCCHHHHHHH		28432305
634	Phosphorylation	EVTSEKRSSPIFQTT CCCCCCCCCCCCEEC		26437020
635	Phosphorylation	VTSEKRSSPIFQTTK CCCCCCCCCCCEECC		22108457
640	Phosphorylation	RSSPIFQTTKTVGST CCCCCCEECCCCCCH		23984901
641	Phosphorylation	SSPIFQTTKTVGSTQ CCCCCEECCCCCCHH		25575281
665	Phosphorylation	AGNASFSSPSSSHLS CCCCCCCCCCCCCCC		28689409
668	Phosphorylation	ASFSSPSSSHLSPEN CCCCCCCCCCCCCCC		28689409
672	Phosphorylation	SPSSSHLSPENENQQ CCCCCCCCCCCCCCC		28689409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
152	T	Phosphorylation	Kinase	CDK5	Q03114	Uniprot
160	Y	Phosphorylation	Kinase	ABL1	P00519	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
152	T	Phosphorylation	Phosphorylated at Thr-152 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NFAT5_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NFAT5_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.