LDHA_RAT - dbPTM
LDHA_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LDHA_RAT
UniProt AC P04642
Protein Name L-lactate dehydrogenase A chain
Gene Name Ldha
Organism Rattus norvegicus (Rat).
Sequence Length 332
Subcellular Localization Cytoplasm.
Protein Description
Protein Sequence MAALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAALKDQLI
------CCCHHHHHH		22.85-
5Succinylation---MAALKDQLIVNL
---CCCHHHHHHHHH		38.41-
5Acetylation---MAALKDQLIVNL
---CCCHHHHHHHHH		38.4122902405
5Succinylation---MAALKDQLIVNL
---CCCHHHHHHHHH		38.41-
14AcetylationQLIVNLLKEEQVPQN
HHHHHHHHHHCCCCC		63.4722902405
22AcetylationEEQVPQNKITVVGVG
HHCCCCCCEEEEECH		34.2126302492
42"N6,N6-dimethyllysine"CAISILMKDLADELA
HHHHHHHHHHHHHHH		46.26-
42MethylationCAISILMKDLADELA
HHHHHHHHHHHHHHH		46.2612692561
57AcetylationLVDVIEDKLKGEMMD
HHHHHHHHHCCCCEE		39.0322902405
57"N6,N6-dimethyllysine"LVDVIEDKLKGEMMD
HHHHHHHHHCCCCEE		39.03-
57MethylationLVDVIEDKLKGEMMD
HHHHHHHHHCCCCEE		39.0312692561
59AcetylationDVIEDKLKGEMMDLQ
HHHHHHHCCCCEECC		59.5722902405
59"N6,N6-dimethyllysine"DVIEDKLKGEMMDLQ
HHHHHHHCCCCEECC		59.57-
59MethylationDVIEDKLKGEMMDLQ
HHHHHHHCCCCEECC		59.5712692561
76AcetylationSLFLKTPKIVSSKDY
CEEECCCCCCCCCCC		62.0622902405
76UbiquitinationSLFLKTPKIVSSKDY
CEEECCCCCCCCCCC		62.06-
79PhosphorylationLKTPKIVSSKDYSVT
ECCCCCCCCCCCEEE		34.8325575281
80PhosphorylationKTPKIVSSKDYSVTA
CCCCCCCCCCCEEEC		20.7425575281
81AcetylationTPKIVSSKDYSVTAN
CCCCCCCCCCEEECC		53.8622902405
83PhosphorylationKIVSSKDYSVTANSK
CCCCCCCCEEECCCE		14.5825575281
83NitrationKIVSSKDYSVTANSK
CCCCCCCCEEECCCE		14.58-
84PhosphorylationIVSSKDYSVTANSKL
CCCCCCCEEECCCEE		24.1129779826
86PhosphorylationSSKDYSVTANSKLVI
CCCCCEEECCCEEEE		17.7428689409
90AcetylationYSVTANSKLVIITAG
CEEECCCEEEEEECC		46.7326302492
118SuccinylationQRNVNIFKFIIPNVV
HHHHCCHHHHCCCCC		31.68-
118AcetylationQRNVNIFKFIIPNVV
HHHHCCHHHHCCCCC		31.6826302492
118SuccinylationQRNVNIFKFIIPNVV
HHHHCCHHHHCCCCC		31.68-
126AcetylationFIIPNVVKYSPQCKL
HHCCCCCCCCCCCCE		35.4125786129
127PhosphorylationIIPNVVKYSPQCKLL
HCCCCCCCCCCCCEE		17.6122609512
145NitrationNPVDILTYVAWKISG
CCHHHHHHHHHHCCC		5.68-
155AcetylationWKISGFPKNRVIGSG
HHCCCCCCCCEECCC		55.9422902405
163S-nitrosocysteineNRVIGSGCNLDSARF
CCEECCCCCCCHHHH		4.97-
163S-nitrosylationNRVIGSGCNLDSARF
CCEECCCCCCCHHHH		4.9722178444
184PhosphorylationRLGVHPLSCHGWVLG
CCCCCEEECCCEEEC		14.4425403869
196PhosphorylationVLGEHGDSSVPVWSG
EECCCCCCCCCCCCC		37.5225403869
197PhosphorylationLGEHGDSSVPVWSGV
ECCCCCCCCCCCCCE		34.8725403869
202PhosphorylationDSSVPVWSGVNVAGV
CCCCCCCCCEEECCE		32.8525403869
213PhosphorylationVAGVSLKSLNPQLGT
ECCEEHHHCCCCCCC		38.3822673903
224AcetylationQLGTDADKEQWKDVH
CCCCCCCHHHHHHHH		54.2322902405
224UbiquitinationQLGTDADKEQWKDVH
CCCCCCCHHHHHHHH		54.23-
224SuccinylationQLGTDADKEQWKDVH
CCCCCCCHHHHHHHH		54.2326843850
228AcetylationDADKEQWKDVHKQVV
CCCHHHHHHHHHHHH		49.9526302492
232AcetylationEQWKDVHKQVVDSAY
HHHHHHHHHHHHHHH		44.6422902405
237PhosphorylationVHKQVVDSAYEVIKL
HHHHHHHHHHHHHHH		22.5722673903
239NitrationKQVVDSAYEVIKLKG
HHHHHHHHHHHHHCC		18.06-
239PhosphorylationKQVVDSAYEVIKLKG
HHHHHHHHHHHHHCC		18.0621738781
243AcetylationDSAYEVIKLKGYTSW
HHHHHHHHHCCCCHH		49.6941296015
243UbiquitinationDSAYEVIKLKGYTSW
HHHHHHHHHCCCCHH		49.69-
247NitrationEVIKLKGYTSWAIGL
HHHHHCCCCHHHHHC		8.94-
278AcetylationHPISTMIKGLYGIKE
CCHHHHHHHHHCCCC		31.8522902405
281PhosphorylationSTMIKGLYGIKEDVF
HHHHHHHHCCCCCEE		26.02-
309PhosphorylationDVVKVTLTPDEEARL
CEEEEEECCCHHHHH		21.2329779826
317AcetylationPDEEARLKKSADTLW
CCHHHHHHHHHHHHH		38.8522902405
318SuccinylationDEEARLKKSADTLWG
CHHHHHHHHHHHHHH		56.31-
318SuccinylationDEEARLKKSADTLWG
CHHHHHHHHHHHHHH		56.31-
318AcetylationDEEARLKKSADTLWG
CHHHHHHHHHHHHHH		56.3122902405
319PhosphorylationEEARLKKSADTLWGI
HHHHHHHHHHHHHHH		29.7721738781
322PhosphorylationRLKKSADTLWGIQKE
HHHHHHHHHHHHHHH		24.9121738781
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LDHA_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LDHA_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LDHA_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LDHA_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LDHA_RAT

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Related Literatures of Post-Translational Modification

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