PGK1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGK1_RAT
• UniProt AC: P16617
• Protein Name: Phosphoglycerate kinase 1
• Gene Name: Pgk1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 417
• Subcellular Localization: Cytoplasm.
• Protein Description: In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility..
• Protein Sequence: MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAAELKSLLGKDVLFLKDCVGSEVENACANPAAGTVILLENLRFHVEEEGKGKDASGNKVKAEPAKIDAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLYDEEGAKIVKDLMAKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGTESSKKYAEAVARAKQIVWNGPVGVFEWEAFARGTKSLMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLSNKLTL ------CCCCCCCCC	40.27	22673903
2	Acetylation	------MSLSNKLTL ------CCCCCCCCC	40.27	-
4	Phosphorylation	----MSLSNKLTLDK ----CCCCCCCCCCC	25.31	23984901
6	Acetylation	--MSLSNKLTLDKLD --CCCCCCCCCCCCC	39.20	22902405
6	Succinylation	--MSLSNKLTLDKLD --CCCCCCCCCCCCC	39.20	-
6	Succinylation	--MSLSNKLTLDKLD --CCCCCCCCCCCCC	39.20	-
8	Phosphorylation	MSLSNKLTLDKLDVK CCCCCCCCCCCCCCC	34.22	25575281
11	Acetylation	SNKLTLDKLDVKGKR CCCCCCCCCCCCCCE	50.10	22637727
15	Acetylation	TLDKLDVKGKRVVMR CCCCCCCCCCEEEEE	59.38	72630343
30	Acetylation	VDFNVPMKNNQITNN EEECCCCCCCCCCCC	46.83	22902405
30	Ubiquitination	VDFNVPMKNNQITNN EEECCCCCCCCCCCC	46.83	-
48	Succinylation	KAAVPSIKFCLDNGA HHHCCCCEEEECCCC	34.07	-
48	Succinylation	KAAVPSIKFCLDNGA HHHCCCCEEEECCCC	34.07	-
48	Acetylation	KAAVPSIKFCLDNGA HHHCCCCEEEECCCC	34.07	22902405
75	Acetylation	DGVPMPDKYSLEPVA CCCCCCCCCCCHHHH	30.76	25786129
76	Phosphorylation	GVPMPDKYSLEPVAA CCCCCCCCCCHHHHH	26.35	22673903
77	Phosphorylation	VPMPDKYSLEPVAAE CCCCCCCCCHHHHHH	31.81	22673903
86	Acetylation	EPVAAELKSLLGKDV HHHHHHHHHHHCCCE	30.48	22902405
87	Phosphorylation	PVAAELKSLLGKDVL HHHHHHHHHHCCCEE	41.26	28432305
91	Acetylation	ELKSLLGKDVLFLKD HHHHHHCCCEEEECH	44.63	22902405
97	Other	GKDVLFLKDCVGSEV CCCEEEECHHHCCHH	41.57	-
97	Acetylation	GKDVLFLKDCVGSEV CCCEEEECHHHCCHH	41.57	-
102	Phosphorylation	FLKDCVGSEVENACA EECHHHCCHHHHHHC	20.33	23984901
115	Phosphorylation	CANPAAGTVILLENL HCCCCCCEEEEEECE	10.31	23984901
131	Malonylation	FHVEEEGKGKDASGN EEEEECCCCCCCCCC	67.10	-
131	Acetylation	FHVEEEGKGKDASGN EEEEECCCCCCCCCC	67.10	22902405
131	N6-malonyllysine	FHVEEEGKGKDASGN EEEEECCCCCCCCCC	67.10	-
133	Acetylation	VEEEGKGKDASGNKV EEECCCCCCCCCCCC	54.32	22902405
141	Ubiquitination	DASGNKVKAEPAKID CCCCCCCCCCHHHHH	48.95	-
146	Acetylation	KVKAEPAKIDAFRAS CCCCCHHHHHHHHHH	52.41	22902405
146	Ubiquitination	KVKAEPAKIDAFRAS CCCCCHHHHHHHHHH	52.41	-
156	Acetylation	AFRASLSKLGDVYVN HHHHHHHHHCCEEEC	62.88	22637687
191	Succinylation	KAGGFLMKKELNYFA CCCCEECHHHHHHHH	45.29	-
191	Succinylation	KAGGFLMKKELNYFA CCCCEECHHHHHHHH	45.29	-
196	Phosphorylation	LMKKELNYFAKALES ECHHHHHHHHHHHHC	19.96	22673903
199	Acetylation	KELNYFAKALESPER HHHHHHHHHHHCCCC	43.54	-
203	Phosphorylation	YFAKALESPERPFLA HHHHHHHCCCCCCCH	32.67	28689409
216	Other	LAILGGAKVADKIQL CHHHCCHHHHHHHHH	41.03	-
216	Acetylation	LAILGGAKVADKIQL CHHHCCHHHHHHHHH	41.03	22902405
220	Acetylation	GGAKVADKIQLINNM CCHHHHHHHHHHHHH	23.71	22902405
264	Ubiquitination	LYDEEGAKIVKDLMA CCCHHHHHHHHHHHH	59.91	-
264	Acetylation	LYDEEGAKIVKDLMA CCCHHHHHHHHHHHH	59.91	22902405
267	Ubiquitination	EEGAKIVKDLMAKAE HHHHHHHHHHHHHHH	48.93	-
267	Acetylation	EEGAKIVKDLMAKAE HHHHHHHHHHHHHHH	48.93	22902405
272	Acetylation	IVKDLMAKAEKNGVK HHHHHHHHHHHCCCE	43.01	22902405
291	Succinylation	VDFVTADKFDENAKT ECEEEHHHCCCCCCC	52.85	26843850
291	Acetylation	VDFVTADKFDENAKT ECEEEHHHCCCCCCC	52.85	22637695
323	Acetylation	CGTESSKKYAEAVAR CCCHHHHHHHHHHHH	52.20	4276169
323	Succinylation	CGTESSKKYAEAVAR CCCHHHHHHHHHHHH	52.20	26843850
323	Other	CGTESSKKYAEAVAR CCCHHHHHHHHHHHH	52.20	-
352	Phosphorylation	WEAFARGTKSLMDEV HHHHHHCCHHHHHHH	16.35	25575281
353	Acetylation	EAFARGTKSLMDEVV HHHHHCCHHHHHHHH	44.40	22902405
354	Phosphorylation	AFARGTKSLMDEVVK HHHHCCHHHHHHHHH	28.85	22673903
361	Acetylation	SLMDEVVKATSRGCI HHHHHHHHHHCCCCE	51.64	22902405
363	Phosphorylation	MDEVVKATSRGCITI HHHHHHHHCCCCEEE	17.15	23984901
364	Phosphorylation	DEVVKATSRGCITII HHHHHHHCCCCEEEE	31.38	23984901
369	Phosphorylation	ATSRGCITIIGGGDT HHCCCCEEEECCCCC	15.60	23984901
388	Acetylation	AKWNTEDKVSHVSTG CCCCCCCCEEEEECC	39.13	22902405
415	Phosphorylation	LPGVDALSNV----- CCCCCHHCCC-----	36.95	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PGK1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGK1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGK1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PGK1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.