K2C1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C1_RAT
• UniProt AC: Q6IMF3
• Protein Name: Keratin, type II cytoskeletal 1
• Gene Name: Krt1 {ECO:0000250|UniProtKB:P04264}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 625
• Subcellular Localization: Cell membrane.
• Protein Description: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity)..
• Protein Sequence: MSFQCSSRSLCRSGGGGGGRNFSSGSAGLVSFQRRSTSSSMRRSGGGGGGRFSGGGFCGSSGGGFGSKSLVNLGGGRSISISVAGGGSSYGGGFGGGSYGGGSFGGGSFGGGVGGGFGGGGFGGGGFGSGGGFGGGRFGGGFGPVCPPGGIQEVTINQSLLQPLNVEVDPQIQKVKSQEREQIKSLNDKFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTQNLDPFFESYISNLRRQVDSLKNDQSRMDSELKNMQDLVEEYRTKYEDEINKRTNAENEFVTIKKDVDSAYMNKAELQARVDNLQQDIDFFSTLYQMELSQMQTQISETNVVLSMDNNRTLDLDGIIAEVKAQYDSICQRSKAEAETFYQSKYEELQITAGKHGDSVKNTKMEISELNRVIQRLRSEIDSVKKQISQMQQNISDAEQRGEKALKDAQNKLNEIEDALTQAKEELTRLLRDYQELMNTKLALDMEIATYRKLLEGEEIRMSGECTPNVSVSVSTSHTSMSGTSSRGGGRYGSGGGGGGGTYGGGSRGGSYGGGSGGGSYGGCSSGGGSGGGSYGGGSSGGHRGGSGGGGGSSGGSYGGSSGGGRGGSSSGGGVKSSGSSSVKFVSTTYSRGTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Methylation	CSSRSLCRSGGGGGG CCCCCCCCCCCCCCC	43.56	-
20	Asymmetric dimethylarginine	SGGGGGGRNFSSGSA CCCCCCCCCCCCCCC	44.27	-
23	Phosphorylation	GGGGRNFSSGSAGLV CCCCCCCCCCCCCEE	37.02	22673903
24	Phosphorylation	GGGRNFSSGSAGLVS CCCCCCCCCCCCEEE	32.41	22673903
26	Phosphorylation	GRNFSSGSAGLVSFQ CCCCCCCCCCEEEEE	22.55	22673903
51	Methylation	SGGGGGGRFSGGGFC CCCCCCCCCCCCCCC	26.32	-
69	Phosphorylation	GGGFGSKSLVNLGGG CCCCCCCCEEECCCC	38.97	-
189	Acetylation	QIKSLNDKFASFIDK HHHHHHHHHHHHHHH	41.58	22902405
192	Phosphorylation	SLNDKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	22673903
196	Acetylation	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	59122439
245	Acetylation	RRQVDSLKNDQSRMD HHHHHHHHHHHHHHH	63.53	22902405
256	Acetylation	SRMDSELKNMQDLVE HHHHHHHHHHHHHHH	46.45	22902405
275	"N6,N6-dimethyllysine"	KYEDEINKRTNAENE HHHHHHHHCCCCCCC	67.28	-
275	Methylation	KYEDEINKRTNAENE HHHHHHHHCCCCCCC	67.28	-
287	Acetylation	ENEFVTIKKDVDSAY CCCCEEEEHHHCHHH	33.29	22902405
288	Acetylation	NEFVTIKKDVDSAYM CCCEEEEHHHCHHHC	60.16	22902405
297	Acetylation	VDSAYMNKAELQARV HCHHHCCHHHHHHHH	27.06	22902405
365	Acetylation	DSICQRSKAEAETFY HHHHHHHHHHHHHHH	53.05	22902405
375	Acetylation	AETFYQSKYEELQIT HHHHHHHHHHHHEEC	40.95	22902405
385	Acetylation	ELQITAGKHGDSVKN HHEECCCCCCCCHHH	41.78	22902405
394	Acetylation	GDSVKNTKMEISELN CCCHHHCHHHHHHHH	43.88	22902405
415	Acetylation	RSEIDSVKKQISQMQ HHHHHHHHHHHHHHH	42.80	22902405
434	Acetylation	DAEQRGEKALKDAQN HHHHHHHHHHHHHHH	62.94	22902405
442	Acetylation	ALKDAQNKLNEIEDA HHHHHHHHHHHHHHH	40.38	22902405
454	Acetylation	EDALTQAKEELTRLL HHHHHHHHHHHHHHH	41.73	22902405
483	Acetylation	MEIATYRKLLEGEEI HHHHHHHHHHCCCCE	47.19	72609703
517	Methylation	SMSGTSSRGGGRYGS CCCCCCCCCCCCCCC	47.76	-
541	Phosphorylation	GGGSRGGSYGGGSGG CCCCCCCCCCCCCCC	24.35	26022182
542	Phosphorylation	GGSRGGSYGGGSGGG CCCCCCCCCCCCCCC	24.06	26022182
546	Phosphorylation	GGSYGGGSGGGSYGG CCCCCCCCCCCCCCC	37.22	26022182
550	Phosphorylation	GGGSGGGSYGGCSSG CCCCCCCCCCCCCCC	24.71	26022182
555	Phosphorylation	GGSYGGCSSGGGSGG CCCCCCCCCCCCCCC	34.98	26022182
556	Phosphorylation	GSYGGCSSGGGSGGG CCCCCCCCCCCCCCC	45.60	26022182
560	Phosphorylation	GCSSGGGSGGGSYGG CCCCCCCCCCCCCCC	37.22	26022182
564	Phosphorylation	GGGSGGGSYGGGSSG CCCCCCCCCCCCCCC	24.71	26022182
574	Methylation	GGSSGGHRGGSGGGG CCCCCCCCCCCCCCC	55.21	-
588	Phosphorylation	GGSSGGSYGGSSGGG CCCCCCCCCCCCCCC	28.87	26022182
596	Methylation	GGSSGGGRGGSSSGG CCCCCCCCCCCCCCC	49.96	-
600	Phosphorylation	GGGRGGSSSGGGVKS CCCCCCCCCCCCCCC	35.96	26022182
601	Phosphorylation	GGRGGSSSGGGVKSS CCCCCCCCCCCCCCC	43.06	26022182

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2C1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of K2C1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.