XPP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XPP1_RAT
• UniProt AC: O54975
• Protein Name: Xaa-Pro aminopeptidase 1
• Gene Name: Xpnpep1 {ECO:0000312|RGD:621274}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 623
• Subcellular Localization: Cytoplasm .
• Protein Description: Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity)..
• Protein Sequence: MAPKVTSELLRQLRQAMRNSECVAEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMDNNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLVPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKEKVADLRLKMAERSIVWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLERIMLFIDGDRIDAPGVKQHLLLDLGLEAEYKIQVLPYKSILSELKTLCADLSPREKVWVSDKASYAVSEAIPKDHRCCMPYTPICIAKAVKNSAESAGMRRAHIKDAVALCELFNWLEQEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPIPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPAKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDALTDKECDWLNSYHQTCRDVIGKELQTQGRQEALEWLLRETEPISRQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
128	Phosphorylation	PLIIPTDYWKKMAKV CEECCHHHHHHHHHH	22.93	-
130	Acetylation	IIPTDYWKKMAKVLR ECCHHHHHHHHHHHH	26.83	22902405
134	Acetylation	DYWKKMAKVLRSAGH HHHHHHHHHHHHCCC	38.00	22902405
147	Acetylation	GHHLVPVKENLVDKI CCCCEECCHHHHHHH	34.51	22902405
287	Acetylation	ADLSPREKVWVSDKA CCCCCCCCEEECCHH	42.55	22902405
293	Acetylation	EKVWVSDKASYAVSE CCEEECCHHHHHHHH	31.55	22902405
304	Acetylation	AVSEAIPKDHRCCMP HHHHHCCCCCCCCCC	61.11	22902405
324	Phosphorylation	IAKAVKNSAESAGMR HHHHHHCHHHHHCCC	27.91	26022182
546	Ubiquitination	VVLVVPAKTKYNFNN EEEEEECCCEECCCC	39.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XPP1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XPP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XPP1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of XPP1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.