| UniProt ID | GNAI2_RAT | |
|---|---|---|
| UniProt AC | P04897 | |
| Protein Name | Guanine nucleotide-binding protein G(i) subunit alpha-2 | |
| Gene Name | Gnai2 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 355 | |
| Subcellular Localization |
Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane Lipid-anchor . Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody (By similarity).. |
|
| Protein Description | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.. | |
| Protein Sequence | MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPQRADDARQLFALSCAAEEQGMLPEDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITQSPLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Myristoylation | ------MGCTVSAED ------CCCCCCHHH | 18.79 | - | |
| 3 | S-palmitoylation | -----MGCTVSAEDK -----CCCCCCHHHH | 3.07 | - | |
| 6 | Phosphorylation | --MGCTVSAEDKAAA --CCCCCCHHHHHHH | 14.05 | 16470654 | |
| 29 | Acetylation | NLREDGEKAAREVKL HHHHHHHHHHHHHHH | 53.53 | 22902405 | |
| 29 | Ubiquitination | NLREDGEKAAREVKL HHHHHHHHHHHHHHH | 53.53 | - | |
| 35 | Acetylation | EKAAREVKLLLLGAG HHHHHHHHHHEECCC | 28.76 | 22902405 | |
| 35 | Ubiquitination | EKAAREVKLLLLGAG HHHHHHHHHHEECCC | 28.76 | - | |
| 46 | Ubiquitination | LGAGESGKSTIVKQM ECCCCCCCCHHHHEE | 54.42 | - | |
| 51 | Ubiquitination | SGKSTIVKQMKIIHE CCCCHHHHEEEEECC | 40.60 | - | |
| 144 | Phosphorylation | VQACFGRSREYQLND HHHHCCCCCCEECCC | 29.82 | 8053895 | |
| 155 | Phosphorylation | QLNDSAAYYLNDLER ECCCCHHHHHHHHHH | 14.27 | - | |
| 198 | Acetylation | TFKDLHFKMFDVGGQ EECCEEEEEEECCCC | 28.10 | 22902405 | |
| 207 | Phosphorylation | FDVGGQRSERKKWIH EECCCCCCCHHHHHH | 33.59 | 8053895 | |
| 249 | Acetylation | NRMHESMKLFDSICN HHHHHHHHHHHHHHC | 56.11 | 140631 | |
| 253 | Phosphorylation | ESMKLFDSICNNKWF HHHHHHHHHHCCCCC | 23.00 | 27097102 | |
| 307 | Acetylation | AASYIQSKFEDLNKR HHHHHHHHHHHHHCC | 36.08 | 22902405 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GNAI2_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GNAI2_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GNAI2_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GNAI2_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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