IDHP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IDHP_RAT
• UniProt AC: P56574
• Protein Name: Isocitrate dehydrogenase [NADP], mitochondrial
• Gene Name: Idh2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 452
• Subcellular Localization: Mitochondrion .
• Protein Description: Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (By similarity)..
• Protein Sequence: MAGYLRAVSSLCRASGSTRTWAPAALNVPSWPEQPRRHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Acetylation	HYAEKRIKVEKPVVE HHHHCCCEEECCEEE	48.66	22902405
48	Acetylation	EKRIKVEKPVVEMDG HCCCEEECCEEECCH	46.21	22902405
48	Succinylation	EKRIKVEKPVVEMDG HCCCEEECCEEECCH	46.21	26843850
67	Acetylation	RIIWQFIKEKLILPH HHHHHHHHHCCCCCC	50.51	22902405
69	Acetylation	IWQFIKEKLILPHVD HHHHHHHCCCCCCCE	35.51	22902405
80	Acetylation	PHVDVQLKYFDLGLP CCCEEEEEEEECCCC	27.12	25786129
80	Succinylation	PHVDVQLKYFDLGLP CCCEEEEEEEECCCC	27.12	-
80	Succinylation	PHVDVQLKYFDLGLP CCCEEEEEEEECCCC	27.12	-
97	Phosphorylation	DQTNDQVTIDSALAT CCCCCCEEHHHHHHH	17.27	23991683
100	Phosphorylation	NDQVTIDSALATQKY CCCEEHHHHHHHCCE	22.72	23991683
104	Phosphorylation	TIDSALATQKYSVAV EHHHHHHHCCEEEEE	26.83	23991683
106	Acetylation	DSALATQKYSVAVKC HHHHHHCCEEEEEEE	34.83	25786129
106	Succinylation	DSALATQKYSVAVKC HHHHHHCCEEEEEEE	34.83	-
106	Succinylation	DSALATQKYSVAVKC HHHHHHCCEEEEEEE	34.83	-
107	Phosphorylation	SALATQKYSVAVKCA HHHHHCCEEEEEEEE	9.88	23991683
108	Phosphorylation	ALATQKYSVAVKCAT HHHHCCEEEEEEEEE	15.61	23991683
112	Acetylation	QKYSVAVKCATITPD CCEEEEEEEEEECCC	14.39	26302492
127	Acetylation	EARVEEFKLKKMWKS HHHHHHHCHHHHCCC	63.78	72587717
129	Acetylation	RVEEFKLKKMWKSPN HHHHHCHHHHCCCCC	40.97	22902405
130	Acetylation	VEEFKLKKMWKSPNG HHHHCHHHHCCCCCC	61.50	22902405
133	Acetylation	FKLKKMWKSPNGTIR HCHHHHCCCCCCCCC	53.16	26302492
134	Phosphorylation	KLKKMWKSPNGTIRN CHHHHCCCCCCCCCH	14.21	23984901
138	Phosphorylation	MWKSPNGTIRNILGG HCCCCCCCCCHHHCC	24.33	23984901
155	Succinylation	FREPIICKNIPRLVP CCCCEECCCCCCCCC	47.72	26843850
155	Acetylation	FREPIICKNIPRLVP CCCCEECCCCCCCCC	47.72	22902405
165	O-linked_Glycosylation	PRLVPGWTKPITIGR CCCCCCCCCCEEEEC	32.62	26446791
165	Phosphorylation	PRLVPGWTKPITIGR CCCCCCCCCCEEEEC	32.62	23991683
166	Succinylation	RLVPGWTKPITIGRH CCCCCCCCCEEEECC	28.10	-
166	Acetylation	RLVPGWTKPITIGRH CCCCCCCCCEEEECC	28.10	22902405
166	Succinylation	RLVPGWTKPITIGRH CCCCCCCCCEEEECC	28.10	-
169	Phosphorylation	PGWTKPITIGRHAHG CCCCCCEEEECCCCC	26.38	23984901
179	Phosphorylation	RHAHGDQYKATDFVV CCCCCCHHCCCCEEE	13.82	-
180	Succinylation	HAHGDQYKATDFVVD CCCCCHHCCCCEEEE	38.89	26843850
180	Succinylation	HAHGDQYKATDFVVD CCCCCHHCCCCEEEE	38.89	-
180	Acetylation	HAHGDQYKATDFVVD CCCCCHHCCCCEEEE	38.89	25786129
182	O-linked_Glycosylation	HGDQYKATDFVVDRA CCCHHCCCCEEEECC	26.31	26446791
193	Succinylation	VDRAGMFKLVFTPKD EECCCCEEEEEECCC	34.54	-
193	Acetylation	VDRAGMFKLVFTPKD EECCCCEEEEEECCC	34.54	22902405
193	Succinylation	VDRAGMFKLVFTPKD EECCCCEEEEEECCC	34.54	-
199	Acetylation	FKLVFTPKDGSGAKE EEEEEECCCCCCCCE	72.21	22902405
199	Succinylation	FKLVFTPKDGSGAKE EEEEEECCCCCCCCE	72.21	26843850
205	Acetylation	PKDGSGAKEWEVYNF CCCCCCCCEEEEEEE	67.87	26302492
243	Acetylation	FQYSIQKKWPLYLST HHHHHHHHCCEEEEC	37.35	22902405
243	Succinylation	FQYSIQKKWPLYLST HHHHHHHHCCEEEEC	37.35	26843850
249	Phosphorylation	KKWPLYLSTKNTIMK HHCCEEEECCCCHHH	24.63	23984901
249	O-linked_Glycosylation	KKWPLYLSTKNTIMK HHCCEEEECCCCHHH	24.63	26446791
250	Phosphorylation	KWPLYLSTKNTIMKA HCCEEEECCCCHHHH	26.22	23984901
251	Acetylation	WPLYLSTKNTIMKAY CCEEEECCCCHHHHC	49.03	22902405
256	Succinylation	STKNTIMKAYDGRFK ECCCCHHHHCCCCHH	39.69	-
256	Acetylation	STKNTIMKAYDGRFK ECCCCHHHHCCCCHH	39.69	22902405
256	Succinylation	STKNTIMKAYDGRFK ECCCCHHHHCCCCHH	39.69	-
263	Succinylation	KAYDGRFKDIFQEIF HHCCCCHHHHHHHHH	48.86	26843850
263	Acetylation	KAYDGRFKDIFQEIF HHCCCCHHHHHHHHH	48.86	22902405
272	Acetylation	IFQEIFDKHYKTDFD HHHHHHHHHCCCCCC	37.78	22902405
275	Acetylation	EIFDKHYKTDFDKNK HHHHHHCCCCCCCCC	41.14	22902405
276	Phosphorylation	IFDKHYKTDFDKNKI HHHHHCCCCCCCCCC	34.43	23991683
280	Succinylation	HYKTDFDKNKIWYEH HCCCCCCCCCCHHHH	61.20	26843850
280	Acetylation	HYKTDFDKNKIWYEH HCCCCCCCCCCHHHH	61.20	22902405
282	Acetylation	KTDFDKNKIWYEHRL CCCCCCCCCHHHHHH	40.12	22902405
282	Succinylation	KTDFDKNKIWYEHRL CCCCCCCCCHHHHHH	40.12	26843850
282	Succinylation	KTDFDKNKIWYEHRL CCCCCCCCCHHHHHH	40.12	-
300	Phosphorylation	MVAQVLKSSGGFVWA HHHHHHHHCCCEEEE	30.01	23991683
301	Phosphorylation	VAQVLKSSGGFVWAC HHHHHHHCCCEEEEE	41.15	23991683
311	Nitration	FVWACKNYDGDVQSD EEEEEECCCCCHHHH	13.54	-
350	Phosphorylation	EAEAAHGTVTRHYRE EHHHHCCCHHHHHHH	14.61	23984901
350	O-linked_Glycosylation	EAEAAHGTVTRHYRE EHHHHCCCHHHHHHH	14.61	26446791
352	Phosphorylation	EAAHGTVTRHYREHQ HHHCCCHHHHHHHHH	16.15	23984901
364	Phosphorylation	EHQKGRPTSTNPIAS HHHCCCCCCCCCHHH	46.99	23984901
365	Phosphorylation	HQKGRPTSTNPIASI HHCCCCCCCCCHHHH	28.95	23984901
366	Phosphorylation	QKGRPTSTNPIASIF HCCCCCCCCCHHHHH	47.71	23984901
384	Succinylation	RGLEHRGKLDGNQDL CCCCCCCCCCCCHHH	43.28	-
384	Acetylation	RGLEHRGKLDGNQDL CCCCCCCCCCCCHHH	43.28	25786129
384	Succinylation	RGLEHRGKLDGNQDL CCCCCCCCCCCCHHH	43.28	26843850
397	Phosphorylation	DLIRFAQTLEKVCVQ HHHHHHHHHHHHHHH	33.19	23991683
400	Acetylation	RFAQTLEKVCVQTVE HHHHHHHHHHHHHHH	44.01	22902405
408	Phosphorylation	VCVQTVESGAMTKDL HHHHHHHCCCCCHHH	27.76	23991683
413	Acetylation	VESGAMTKDLAGCIH HHCCCCCHHHHHHHH	37.35	22902405
423	Phosphorylation	AGCIHGLSNVKLNEH HHHHHHHCCCCCCHH	44.14	23984901
426	Acetylation	IHGLSNVKLNEHFLN HHHHCCCCCCHHHCC	50.25	26302492
434	Phosphorylation	LNEHFLNTTDFLDTI CCHHHCCCHHHHHHH	29.86	23991683
435	Phosphorylation	NEHFLNTTDFLDTIK CHHHCCCHHHHHHHH	24.55	23991683
440	Phosphorylation	NTTDFLDTIKSNLDR CCHHHHHHHHHHHHH	32.24	23991683
442	Acetylation	TDFLDTIKSNLDRAL HHHHHHHHHHHHHHH	35.07	22902405
443	Phosphorylation	DFLDTIKSNLDRALG HHHHHHHHHHHHHHC	38.48	23991683

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IDHP_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
413	K	Acetylation	Acetylation at Lys-413 dramatically reduces catalytic activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IDHP_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of IDHP_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.