NUP93_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUP93_RAT
• UniProt AC: Q66HC5
• Protein Name: Nuclear pore complex protein Nup93
• Gene Name: Nup93
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 819
• Subcellular Localization: Nucleus membrane ; Peripheral membrane protein . Nucleus, nuclear pore complex . Nucleus envelope . Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore..
• Protein Description: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling..
• Protein Sequence: MDTEGFGELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLRSRTLTRTSQETADVKASVLLGSRGLDISHISQRLESLSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEWEQVKQRILHTLLASGEDALDFTQESEPSYVSDVSPPGRSSLDSIEMAYARQIYIYNEKIVSGHLQPNLVDLCASVAELDDKSISDMWAMVKQMTDVVLTPATDALKSRSSVEVRMDFVKQALGYLEQSYKNYTLVTVFGNLHQAQLGGVPGTYQLVRSFLNIKLPAPSPGLQDGEVEGHPVWALIYYCMRCGDLLAASQVVSRAQHQLGEFKTWFQEYMNSKDRRLSPATENKLRLHYRRALRNNTDPYKRAVYCIIGRCDITDNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGESHFTVNQQPFLYFQVLFLTAQFEAAIAFLFRMERLRCHAVHVALVLFELKLLLKSSGQSAQLLSHEPGDPPCMRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKDSQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVIDKFTSDTKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNKERLKNMALSIAERYRAQGISANKFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIDRLKLVPLNQESMEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPSSATRPQRVIEDRDSQLRSQARALITFAGMIPYRTSGDTNARLVQMEVLMN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	GERLRSRTLTRTSQE HHHHHHHCCCCCCHH	33.46	23984901
49	Phosphorylation	RLRSRTLTRTSQETA HHHHHCCCCCCHHHH	31.15	23984901
51	Phosphorylation	RSRTLTRTSQETADV HHHCCCCCCHHHHHH	29.53	28432305
52	Phosphorylation	SRTLTRTSQETADVK HHCCCCCCHHHHHHH	23.80	21630457
55	Phosphorylation	LTRTSQETADVKASV CCCCCHHHHHHHHHH	22.11	23984901
66	Phosphorylation	KASVLLGSRGLDISH HHHHHHCCCCCCHHH	24.12	-
72	Phosphorylation	GSRGLDISHISQRLE CCCCCCHHHHHHHHH	17.90	27097102
75	Phosphorylation	GLDISHISQRLESLS CCCHHHHHHHHHHHH	12.11	27097102
80	Phosphorylation	HISQRLESLSAATTF HHHHHHHHHHCCCCC	32.01	27097102
112	Phosphorylation	EKDNALLSAIEESRK HHHHHHHHHHHHHHH	28.22	23984901
162	Phosphorylation	ALDFTQESEPSYVSD HHCCCCCCCCCCCCC	45.02	27097102
165	Phosphorylation	FTQESEPSYVSDVSP CCCCCCCCCCCCCCC	33.83	27097102
166	Phosphorylation	TQESEPSYVSDVSPP CCCCCCCCCCCCCCC	18.06	27097102
168	Phosphorylation	ESEPSYVSDVSPPGR CCCCCCCCCCCCCCC	24.86	27097102
171	Phosphorylation	PSYVSDVSPPGRSSL CCCCCCCCCCCCCCH	30.30	28432305
176	Phosphorylation	DVSPPGRSSLDSIEM CCCCCCCCCHHHHHH	40.96	23984901
177	Phosphorylation	VSPPGRSSLDSIEMA CCCCCCCCHHHHHHH	34.53	23984901
180	Phosphorylation	PGRSSLDSIEMAYAR CCCCCHHHHHHHHHE	26.24	21630457
236	Phosphorylation	QMTDVVLTPATDALK HHHCEEEECCCHHHH	10.16	23984901
239	Phosphorylation	DVVLTPATDALKSRS CEEEECCCHHHHCCC	24.02	23984901
364	Phosphorylation	NSKDRRLSPATENKL CCCCCCCCHHHHHHH	15.63	26022182
428	Phosphorylation	VCFDDDGTSSPQDRL EEECCCCCCCHHHHH	32.78	27097102
429	Phosphorylation	CFDDDGTSSPQDRLT EECCCCCCCHHHHHC	45.62	27097102
430	Phosphorylation	FDDDGTSSPQDRLTL ECCCCCCCHHHHHCH	26.81	27097102
669	Phosphorylation	RLKNMALSIAERYRA HHHHHHHHHHHHHHH	15.37	27097102
766	Phosphorylation	QFKRLKGTSPSSATR HHHHHCCCCCCCCCC	35.56	28432305
767	Phosphorylation	FKRLKGTSPSSATRP HHHHCCCCCCCCCCC	31.30	27097102
769	Phosphorylation	RLKGTSPSSATRPQR HHCCCCCCCCCCCHH	32.16	27097102
770	Phosphorylation	LKGTSPSSATRPQRV HCCCCCCCCCCCHHH	36.72	28432305
772	Phosphorylation	GTSPSSATRPQRVIE CCCCCCCCCCHHHHC	44.84	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUP93_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUP93_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUP93_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUP62_RAT	Nup62	physical	9348540

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.