NUP62_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUP62_RAT
• UniProt AC: P17955
• Protein Name: Nuclear pore glycoprotein p62
• Gene Name: Nup62
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 525
• Subcellular Localization: Nucleus, nuclear pore complex . Cytoplasm, cytoskeleton, spindle pole . Nucleus envelope . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Central region of the nuclear pore, within the transporter. During mitotic cell division,
• Protein Description: Essential component of the nuclear pore complex. [PubMed: 2190987]
• Protein Sequence: MSGFNFGGTGAPAGGFTFGTAKTATTTPATGFSFSASGTGTGGFNFGTPSQPAATTPSTSLFSLATQTSTTQTPGFNFGTTPASGGTGFSLGISTPKLSLSSTAATPATANTGSFGLGSSTLTNAISGASTSSQGTAPTGFVFGSSTTSAPSTGTTGFSFTSGSASQPGASGFNIGSVGSLAQPTALSGSPFTPATLATTTAGATQPAAATPTAATTSAGSTLFASIAAAPASSSTTVLSLSAPATTAATPTAGTLGFSLKAPGAAPGASTTSTTTTTTTTTTTASTSSSTTTTGFALSLKPLVPAGPSSVAATALPASSTAVGTTTGPAMTYAQLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEESVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNMAGGPADTSDPLQQICKILNAHMDSLQWVDQSSALLQRRVEEASRVCESRRKEQERSLRIAFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGFNFGGT ------CCCCCCCCC	52.68	-
259	O-linked_Glycosylation	TAGTLGFSLKAPGAA CCCCCEEEEECCCCC	27.45	12526585
411	Phosphorylation	KELEDLLSPLEESVK HHHHHHHHHHHHHHH	34.43	27097102
416	Phosphorylation	LLSPLEESVKEQSGT HHHHHHHHHHHHCCC	29.16	28551015
421	Phosphorylation	EESVKEQSGTIYLQH HHHHHHHCCCEEEEE	38.71	-
425	Phosphorylation	KEQSGTIYLQHADEE HHHCCCEEEEECCHH	10.51	-
471	O-linked_Glycosylation	AGGPADTSDPLQQIC CCCCCCCCCHHHHHH	37.47	28951553

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUP62_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUP62_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUP62_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAU2_RAT	Stau2	physical	15970630
NUP54_RAT	Nup54	physical	24574455

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

O-linked Glycosylation

"Partial cDNA sequence encoding a nuclear pore protein modified by O-linked N-acetylglucosamine.";
D'Onofrio M., Starr C.M., Park M.K., Holt G.D., Haltiwanger R.S.,Hart G.W., Hanover J.A.;
Proc. Natl. Acad. Sci. U.S.A. 85:9595-9599(1988).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 370-525, PARTIAL PROTEIN SEQUENCE, ANDGLYCOSYLATION AT SER-471.
PubMed: 3200844