STAU2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAU2_RAT
• UniProt AC: Q68SB1
• Protein Name: Double-stranded RNA-binding protein Staufen homolog 2
• Gene Name: Stau2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 571
• Subcellular Localization: Nucleus, nucleolus. Nucleus. Cytoplasm. Endoplasmic reticulum. Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and may require the exportin XPO5. Nuclear export of isoform 2 and isofo
• Protein Description: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body..
• Protein Sequence: MANPKEKTPMCLVNELARFHSIQPQYKLLNESGPAHSKMFSVQLSLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKPFPNYRANYNFRGMYNQRYHCPMPKIFYVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQNEPIPEKSPQNGESGKEMDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLPPLPVIEKPKLFFKKRPKTIIKAGPEYGQGMNPISRLAQIQQARKEKEPDYVLLSERGMPRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAMLLQLGYKASTSLQDQLDKTGENKGWSGPKPGFPEPANNTPKGILHLSPDVYQEMEASRHRVTSGTTLGYLSPKDMNQPSSSFFSVESPSPTSSAPAARELLMNGTSPAAEAIGLKGSSPTPPCSSVQPSKQLEYLARIQGFQAALSALKQFSEQGLESIDGVVNVENGSLEKQAKHLREKADNNQANPGSITQDCKKSKSVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ANPKEKTPMCLVNEL CCCCCCCCCHHHHHH	23.66	-
9 (in isoform 3)	Phosphorylation	-	23.66	16641100
9 (in isoform 2)	Phosphorylation	-	23.66	16641100
13	Phosphorylation	EKTPMCLVNELARFH CCCCCHHHHHHHHHH	4.44	-
13 (in isoform 3)	Phosphorylation	-	4.44	16641100
13 (in isoform 2)	Phosphorylation	-	4.44	16641100
18 (in isoform 3)	Phosphorylation	-	42.30	16641100
18 (in isoform 2)	Phosphorylation	-	42.30	16641100
18	Phosphorylation	CLVNELARFHSIQPQ HHHHHHHHHHCCCHH	42.30	-
21	Phosphorylation	NELARFHSIQPQYKL HHHHHHHCCCHHHHH	21.87	-
21 (in isoform 3)	Phosphorylation	-	21.87	16641100
21 (in isoform 2)	Phosphorylation	-	21.87	16641100
45	Phosphorylation	KMFSVQLSLGEQTWE HEEEEEEECCCCCCC	19.76	-
50	Phosphorylation	QLSLGEQTWESEGSS EEECCCCCCCCCCHH	27.22	-
53	Phosphorylation	LGEQTWESEGSSIKK CCCCCCCCCCHHHHH	38.53	-
81	Ubiquitination	TLPKPVQKPPKSNVN CCCCCCCCCCCCCCC	64.62	-
106	Ubiquitination	ELNGLAMKRGEPAIY EECCEEECCCCCCCC	52.20	-
188	Phosphorylation	NEPIPEKSPQNGESG CCCCCCCCCCCCCCC	30.01	27097102
194	Phosphorylation	KSPQNGESGKEMDDD CCCCCCCCCCCCCCC	57.47	27097102
379	Phosphorylation	QLGYKASTSLQDQLD HHCHHCCCCHHHHHH	38.01	28432305
380	Phosphorylation	LGYKASTSLQDQLDK HCHHCCCCHHHHHHH	22.87	28432305
395	Phosphorylation	TGENKGWSGPKPGFP CCCCCCCCCCCCCCC	54.61	-
416	Phosphorylation	PKGILHLSPDVYQEM CCEEEECCHHHHHHH	14.33	28432305
426	Phosphorylation	VYQEMEASRHRVTSG HHHHHHHHHCCCCCC	18.47	-
432	Phosphorylation	ASRHRVTSGTTLGYL HHHCCCCCCCCEEEC	31.14	25575281
434	Phosphorylation	RHRVTSGTTLGYLSP HCCCCCCCCEEECCH	20.72	25575281
435	Phosphorylation	HRVTSGTTLGYLSPK CCCCCCCCEEECCHH	23.01	25575281
438	Phosphorylation	TSGTTLGYLSPKDMN CCCCCEEECCHHHCC	13.71	27097102
440	Phosphorylation	GTTLGYLSPKDMNQP CCCEEECCHHHCCCC	22.78	27097102
456	Phosphorylation	SSFFSVESPSPTSSA CCCCEECCCCCCCCC	28.64	28689409
458	Phosphorylation	FFSVESPSPTSSAPA CCEECCCCCCCCCHH	50.52	28689409
460	Phosphorylation	SVESPSPTSSAPAAR EECCCCCCCCCHHHH	39.38	28689409
486	Phosphorylation	EAIGLKGSSPTPPCS HHHCCCCCCCCCCCC	31.40	27097102
487	Phosphorylation	AIGLKGSSPTPPCSS HHCCCCCCCCCCCCC	41.27	28432305
489	Phosphorylation	GLKGSSPTPPCSSVQ CCCCCCCCCCCCCCC	41.64	27097102
493	Phosphorylation	SSPTPPCSSVQPSKQ CCCCCCCCCCCHHHH	39.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STAU2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAU2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAU2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUP62_RAT	Nup62	physical	15970630
NXF1_RAT	Nxf1	physical	15970630
RBM8A_RAT	Rbm8a	physical	15970630
MGN2_HUMAN	MAGOHB	physical	15970630

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.