NXF1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NXF1_RAT
• UniProt AC: O88984
• Protein Name: Nuclear RNA export factor 1
• Gene Name: Nxf1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 618
• Subcellular Localization: Nucleus, nucleoplasm . Nucleus speckle . Cytoplasm . Nucleus . Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the
• Protein Description: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export..
• Protein Sequence: MADEGKSYNEHDDRVSFPQRRKKGRGPFRWKCGVGNRRSGRGGSGIRSSRFEEDDGDVAMNDPQDGPRVRFNPYTTRPNRRRDTWHDRDRIHVTVRRDRAPQERGGAGTSQDGTTKNWFKITIPYGKKYDKMWLLSMIQSKCSVPFNPIEFHYENTRAHFFVENATTASALKAVNYKIQDRENGRISIIINSSAPPYIVQNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRGCMAAALRIIEENIPELLSLNLSNNRLYKLDDMSSIVQKAPNLKILNLSGNELKSEWELDKIKGLKLEELWLDRNPMCDTFLDQSTYISTIRERFPKLLRLDGHELPPPIAFDVEAPTMLPPCKGSYFGTENLKSLVLHFLQQYYAIYDSGDRQGLLDAYHDGACCSLSTPSNPQNPVRHNLAKYFNDSRNVKKIKDTTTRFRLLKHTRLNVVAFLNELPKTHHDVNSFVVDISAQTSTLLCFSVNGVFKEVDGKSRDSLRAFTRTFIAVPASNSGLCIVNDELFVRNASPEEIQRAFAMPAPTPSSSPVPTLSQEQQDMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAFMK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADEGKSYN ------CCCCCCCCC	24.46	-
20	Methylation	DRVSFPQRRKKGRGP CCCCCCHHHCCCCCC	53.26	26494179
41	Asymmetric dimethylarginine	VGNRRSGRGGSGIRS CCCCCCCCCCCCCCC	47.77	-
41	Methylation	VGNRRSGRGGSGIRS CCCCCCCCCCCCCCC	47.77	-
125	Nitrated tyrosine	WFKITIPYGKKYDKM EEEEEEECCCCCCHH	37.41	-
125	Nitration	WFKITIPYGKKYDKM EEEEEEECCCCCCHH	37.41	-
222	Phosphorylation	MSKRYDGSQQALDLK HHHCCCCCCCCCCCC	19.07	23984901
298	Phosphorylation	NLKILNLSGNELKSE CCEEEECCCCHHCCH	38.20	23984901
304	Phosphorylation	LSGNELKSEWELDKI CCCCHHCCHHHHHHC	61.64	23984901
553	Phosphorylation	AFAMPAPTPSSSPVP HHCCCCCCCCCCCCC	37.60	27097102
555	Phosphorylation	AMPAPTPSSSPVPTL CCCCCCCCCCCCCCC	46.02	27097102
556	Phosphorylation	MPAPTPSSSPVPTLS CCCCCCCCCCCCCCC	39.60	27097102
557	Phosphorylation	PAPTPSSSPVPTLSQ CCCCCCCCCCCCCCH	33.96	27097102
561	Phosphorylation	PSSSPVPTLSQEQQD CCCCCCCCCCHHHHH	39.00	27097102
563	Phosphorylation	SSPVPTLSQEQQDML CCCCCCCCHHHHHHH	33.86	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NXF1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NXF1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NXF1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAU2_RAT	Stau2	physical	15970630

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.