ACON_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACON_RAT
• UniProt AC: Q9ER34
• Protein Name: Aconitate hydratase, mitochondrial
• Gene Name: Aco2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 780
• Subcellular Localization: Mitochondrion .
• Protein Description: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate..
• Protein Sequence: MAPYSLLVTRLQKALGVRQYHVASALCQRAKVAMSHFEPSEYIRYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDHLIEAQLGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGTLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRADIANLAEEFKDHLVPDPGCQYDQVIEINLNELKPHINGPFTPDLAHPVADVGTVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPDADELPRSDFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPSDYNKIHPVDKLTIQGLKDFAPGKPLNCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Pyrrolidone_carboxylic_acid	HVASALCQRAKVAMS HHHHHHHHHHHHHHH	49.57	-
31	Succinylation	SALCQRAKVAMSHFE HHHHHHHHHHHHCCC	32.49	-
31	Succinylation	SALCQRAKVAMSHFE HHHHHHHHHHHHCCC	32.49	-
35	Phosphorylation	QRAKVAMSHFEPSEY HHHHHHHHCCCHHHH	18.45	23991683
35	O-linked_Glycosylation	QRAKVAMSHFEPSEY HHHHHHHHCCCHHHH	18.45	27213235
40	Phosphorylation	AMSHFEPSEYIRYDL HHHCCCHHHHHCHHH	35.52	23991683
42	Phosphorylation	SHFEPSEYIRYDLLE HCCCHHHHHCHHHHH	8.60	23991683
50	Succinylation	IRYDLLEKNINIVRK HCHHHHHHHHHHHHH	64.20	26843850
50	Succinylation	IRYDLLEKNINIVRK HCHHHHHHHHHHHHH	64.20	-
50	Acetylation	IRYDLLEKNINIVRK HCHHHHHHHHHHHHH	64.20	22902405
68	Acetylation	RPLTLSEKIVYGHLD CCCCHHCHHHCCCCC	33.81	22902405
71	Phosphorylation	TLSEKIVYGHLDDPA CHHCHHHCCCCCCHH	11.42	2917105
86	Acetylation	NQEIERGKTYLRLRP HCCHHCCCCEEECCC	39.97	22902405
88	Phosphorylation	EIERGKTYLRLRPDR CHHCCCCEEECCCCH	8.03	31136881
138	Acetylation	EAQLGGEKDLRRAKD HHHHCCHHHHHHHHH	66.39	22902405
138	Succinylation	EAQLGGEKDLRRAKD HHHHCCHHHHHHHHH	66.39	-
138	Succinylation	EAQLGGEKDLRRAKD HHHHCCHHHHHHHHH	66.39	-
144	Succinylation	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	-
144	Acetylation	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	22902405
144	Succinylation	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	-
151	Phosphorylation	KDINQEVYNFLATAG HHHCHHHHHHHHHCC	10.23	31136875
160	Acetylation	FLATAGAKYGVGFWR HHHHCCCCCCCCEEC	41.44	26302492
228	Acetylation	PWELKCPKVIGVKLT CCHHCCCCEEEEEEE	56.82	22902405
233	Succinylation	CPKVIGVKLTGTLSG CCCEEEEEEEEECCC	34.81	-
233	Succinylation	CPKVIGVKLTGTLSG CCCEEEEEEEEECCC	34.81	-
233	Acetylation	CPKVIGVKLTGTLSG CCCEEEEEEEEECCC	34.81	22902405
245	Acetylation	LSGWTSPKDVILKVA CCCCCCHHHHHEEEE	65.48	22902405
256	O-linked_Glycosylation	LKVAGILTVKGGTGA EEEEEEEEEECCCEE	20.46	27213235
304	Acetylation	FPYNHRMKKYLSKTG CCCHHHHHHHHHHHC	37.92	22902405
305	Acetylation	PYNHRMKKYLSKTGR CCHHHHHHHHHHHCC	41.92	22902405
306	Phosphorylation	YNHRMKKYLSKTGRA CHHHHHHHHHHHCCH	15.64	23991683
308	Phosphorylation	HRMKKYLSKTGRADI HHHHHHHHHHCCHHH	25.69	23991683
309	Acetylation	RMKKYLSKTGRADIA HHHHHHHHHCCHHHH	53.02	22902405
310	Phosphorylation	MKKYLSKTGRADIAN HHHHHHHHCCHHHHH	28.64	23991683
401	Acetylation	GRSAAVAKQALAHGL HHHHHHHHHHHHCCC	29.52	22902405
411	Succinylation	LAHGLKCKSQFTITP HHCCCCCEEEEEECC	45.78	-
411	Succinylation	LAHGLKCKSQFTITP HHCCCCCEEEEEECC	45.78	-
420	O-linked_Glycosylation	QFTITPGSEQIRATI EEEECCCCHHHEEEE	27.77	27213235
458	Acetylation	CIGQWDRKDIKKGEK CCCCCCHHHHCCCCC	62.42	26302492
461	Acetylation	QWDRKDIKKGEKNTI CCCHHHHCCCCCCEE	65.93	26302492
462	Acetylation	WDRKDIKKGEKNTIV CCHHHHCCCCCCEEE	73.05	22902405
467	Phosphorylation	IKKGEKNTIVTSYNR HCCCCCCEEEEEEEC	28.08	22673903
470	Phosphorylation	GEKNTIVTSYNRNFT CCCCEEEEEEECCCC	22.95	46314501
471	Phosphorylation	EKNTIVTSYNRNFTG CCCEEEEEEECCCCC	14.98	22673903
471	O-linked_Glycosylation	EKNTIVTSYNRNFTG CCCEEEEEEECCCCC	14.98	27213235
472	Phosphorylation	KNTIVTSYNRNFTGR CCEEEEEEECCCCCC	14.58	23991683
515	Phosphorylation	NPETDFLTGKDGKKF CCCCCCCCCCCCCEE	42.02	23991683
517	Acetylation	ETDFLTGKDGKKFKL CCCCCCCCCCCEEEE	59.06	22902405
517	Succinylation	ETDFLTGKDGKKFKL CCCCCCCCCCCEEEE	59.06	-
517	Succinylation	ETDFLTGKDGKKFKL CCCCCCCCCCCEEEE	59.06	-
520	Acetylation	FLTGKDGKKFKLEAP CCCCCCCCEEEEECC	66.23	22902405
521	Acetylation	LTGKDGKKFKLEAPD CCCCCCCEEEEECCC	53.94	22902405
523	Succinylation	GKDGKKFKLEAPDAD CCCCCEEEEECCCCC	55.06	-
523	Acetylation	GKDGKKFKLEAPDAD CCCCCEEEEECCCCC	55.06	22902405
523	Succinylation	GKDGKKFKLEAPDAD CCCCCEEEEECCCCC	55.06	26843850
535	Phosphorylation	DADELPRSDFDPGQD CCCCCCHHHCCCCCC	40.46	23991683
544	Phosphorylation	FDPGQDTYQHPPKDS CCCCCCCCCCCCCCC	17.08	17997986
549	Acetylation	DTYQHPPKDSSGQRV CCCCCCCCCCCCCCC	74.76	22902405
549	Succinylation	DTYQHPPKDSSGQRV CCCCCCCCCCCCCCC	74.76	-
549	Succinylation	DTYQHPPKDSSGQRV CCCCCCCCCCCCCCC	74.76	-
559	Phosphorylation	SGQRVDVSPTSQRLQ CCCCCCCCCCHHHHH	20.28	21738781
561	Phosphorylation	QRVDVSPTSQRLQLL CCCCCCCCHHHHHHC	29.95	23991683
562	Phosphorylation	RVDVSPTSQRLQLLE CCCCCCCHHHHHHCC	19.38	23991683
562	O-linked_Glycosylation	RVDVSPTSQRLQLLE CCCCCCCHHHHHHCC	19.38	27213235
573	Succinylation	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	26843850
573	Acetylation	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	22902405
573	Succinylation	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	-
577	Acetylation	PFDKWDGKDLEDLQI CCCCCCCCCHHHHEE	57.58	22902405
577	Succinylation	PFDKWDGKDLEDLQI CCCCCCCCCHHHHEE	57.58	-
577	Succinylation	PFDKWDGKDLEDLQI CCCCCCCCCHHHHEE	57.58	-
587	Acetylation	EDLQILIKVKGKCTT HHHEEEEEECCEECC	34.15	26302492
591	Succinylation	ILIKVKGKCTTDHIS EEEEECCEECCCCHH	23.77	-
591	Succinylation	ILIKVKGKCTTDHIS EEEEECCEECCCCHH	23.77	-
605	Succinylation	SAAGPWLKFRGHLDN HCCCCCCEECCCHHH	29.19	-
605	Acetylation	SAAGPWLKFRGHLDN HCCCCCCEECCCHHH	29.19	22902405
605	Succinylation	SAAGPWLKFRGHLDN HCCCCCCEECCCHHH	29.19	-
628	Succinylation	AINIENGKANSVRNA EEEEECCCCCHHHHH	56.85	-
628	Succinylation	AINIENGKANSVRNA EEEEECCCCCHHHHH	56.85	-
628	Acetylation	AINIENGKANSVRNA EEEEECCCCCHHHHH	56.85	22902405
652	Acetylation	DTARYYKKHGIRWVV CHHHHHHHHCCEEEE	30.83	22902405
665	Phosphorylation	VVIGDENYGEGSSRE EEECCCCCCCCCCCC	17.95	23991683
669	Phosphorylation	DENYGEGSSREHAAL CCCCCCCCCCCCCCC	23.17	9543205
670	Phosphorylation	ENYGEGSSREHAALE CCCCCCCCCCCCCCC	53.17	24945867
689	Succinylation	GGRAIITKSFARIHE CCEEEEEHHHHHHHH	32.92	-
689	Succinylation	GGRAIITKSFARIHE CCEEEEEHHHHHHHH	32.92	-
689	Acetylation	GGRAIITKSFARIHE CCEEEEEHHHHHHHH	32.92	22902405
700	Acetylation	RIHETNLKKQGLLPL HHHHHCCHHCCCCCC	45.16	22902405
717	Acetylation	ADPSDYNKIHPVDKL CCHHHCCCCCCCCEE	35.84	22902405
723	Succinylation	NKIHPVDKLTIQGLK CCCCCCCEEEECCCC	48.00	-
723	Acetylation	NKIHPVDKLTIQGLK CCCCCCCEEEECCCC	48.00	22902405
723	Succinylation	NKIHPVDKLTIQGLK CCCCCCCEEEECCCC	48.00	-
730	Succinylation	KLTIQGLKDFAPGKP EEEECCCCCCCCCCC	58.59	-
730	Succinylation	KLTIQGLKDFAPGKP EEEECCCCCCCCCCC	58.59	-
730	Acetylation	KLTIQGLKDFAPGKP EEEECCCCCCCCCCC	58.59	26302492
736	Acetylation	LKDFAPGKPLNCIIK CCCCCCCCCEEEEEE	45.32	26302492
743	Acetylation	KPLNCIIKHPNGTQE CCEEEEEECCCCCEE	32.85	26302492

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
71	Y	Phosphorylation	Kinase	FGR	P09769	PSP
71	Y	Phosphorylation	Kinase	FGR	Q6P6U0	PSP
544	Y	Phosphorylation	Kinase	FGR	P09769	PSP
544	Y	Phosphorylation	Kinase	FGR	Q6P6U0	PSP
665	Y	Phosphorylation	Kinase	FGR	P09769	PSP
665	Y	Phosphorylation	Kinase	FGR	Q6P6U0	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACON_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACON_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ACON_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.