FLNC_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FLNC_RAT
• UniProt AC: D3ZHA0
• Protein Name: Filamin-C
• Gene Name: Flnc
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 2726
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fra
• Protein Description: Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers..
• Protein Sequence: MMNNSNYSDASGLGLLDEADEMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVQNAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDNTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVIPGKYVVTITWGGYAIPRSPFEVQVSPEAGAQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDRGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDRPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTVIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGHYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLSRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKVQGLNSKVAVGEEQAFLVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGSGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIQPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPIPKFPTRVHVQPAVDTSGIKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYVPFTPGDYDVNITFGGQPIPGSPFRVPVKDVVDPGKVKCSGPGLGTGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLACDPLPHVEEPAEVLQLHQPYAPLRPGTCPTHWATEEPVVPVEPLESMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSGHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITEGDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTQNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGASYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MMNNSNYSDASG ---CCCCCCCCCCCC		-
36	Acetylation	LAEDAPWKKIQQNTF HHHCCCHHHHHHHHH		7668577
42	Phosphorylation	WKKIQQNTFTRWCNE HHHHHHHHHHHHHHH		23984901
59	Phosphorylation	KCVGKRLTDLQRDLS HHHHHHHHHHHHHHH		30181290
511	Acetylation	GAGSGELKVTVKGPK CCCCCEEEEEEECCC		-
735	Acetylation	RCSYVPTKPIKHTVI EEEECCCCCCCEEEE		26302492
738	Acetylation	YVPTKPIKHTVIISW ECCCCCCCEEEEEEE		26302492
1003	Methylation	GQGQLDVRMTSPSRR CCCCEEEEECCCCCC		-
1015	Acetylation	SRRPIPCKLEPGSGA CCCCCCCCCCCCCCC		66734001
1020	Phosphorylation	PCKLEPGSGAEAQAV CCCCCCCCCCCEEEE		27097102
1162	Phosphorylation	DPSKVRASGPGLERG CHHHCCCCCCCCCCC		-
1301	Phosphorylation	LNPSGAKTDTYVTDN ECCCCCCCCEEEEEC		28826663
1303	Phosphorylation	PSGAKTDTYVTDNGD CCCCCCCEEEEECCC		28826663
1304	Phosphorylation	SGAKTDTYVTDNGDG CCCCCCEEEEECCCC		28826663
1306	Phosphorylation	AKTDTYVTDNGDGTY CCCCEEEEECCCCEE		28826663
1312	Phosphorylation	VTDNGDGTYRVQYTA EEECCCCEEEEEEEE		28826663
1313	Phosphorylation	TDNGDGTYRVQYTAY EECCCCEEEEEEEEE		28826663
1331	Phosphorylation	VHLVEVLYDEVAVPK EEEEEEEECCCCCCC		22673903
1339	Phosphorylation	DEVAVPKSPFRVGVT CCCCCCCCCCCEECC		22673903
1531	Acetylation	EVPRSPFKIKVLPAH CCCCCCCEEEEEECC		72616751
1936	Acetylation	IIVRFDDKHIPGSPF EEEEECCCCCCCCCE		72610001
2043	Phosphorylation	PSEIGDASKVRVWGK HHHCCCHHHEEEEEC		-
2234	Phosphorylation	LGRERLGSFGSITRQ HCCCCCCCCCCCCCC		29779826
2237	Phosphorylation	ERLGSFGSITRQQEG CCCCCCCCCCCCCCC		27097102
2239	Phosphorylation	LGSFGSITRQQEGEA CCCCCCCCCCCCCCC		27097102
2413	Phosphorylation	SDDARRLTVTSLQET CHHHHHEEEEEHHHH		17564427
2464	Acetylation	VSELDSDKHTIRFIP EEECCCCCCEEEEEE		26302492
2587	Phosphorylation	GPQHIVGSPFKAKVT CCCCEECCCCCCEEC		-
2618	Phosphorylation	LVETVTKSSSSRGAS EEEEECCCCCCCCCC		-
2621	Phosphorylation	TVTKSSSSRGASYSS EECCCCCCCCCCCCC		-
2625	Phosphorylation	SSSSRGASYSSIPKF CCCCCCCCCCCCCCC		27097102
2627	Phosphorylation	SSRGASYSSIPKFSS CCCCCCCCCCCCCCC		27097102
2628	Phosphorylation	SRGASYSSIPKFSSD CCCCCCCCCCCCCCC		27097102
2633	Phosphorylation	YSSIPKFSSDASKVV CCCCCCCCCCCHHEE		-
2656	Phosphorylation	AFVGQKNSFTVDCSK HHCCCCCEEEEECHH		27097102
2715	Phosphorylation	IVKWGDESVPGSPFK EEEECCCCCCCCCCE		-
2719	Phosphorylation	GDESVPGSPFKVNVP CCCCCCCCCCEECCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2413	T	Phosphorylation	Kinase	PRKACA	P00517	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FLNC_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FLNC_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of FLNC_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.