GSTP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTP1_RAT
• UniProt AC: P04906
• Protein Name: Glutathione S-transferase P
• Gene Name: Gstp1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 210
• Subcellular Localization: Cytoplasm. Mitochondrion. Nucleus. The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization..
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity)..
• Protein Sequence: MPPYTIVYFPVRGRCEATRMLLADQGQSWKEEVVTIDVWLQGSLKSTCLYGQLPKFEDGDLTLYQSNAILRHLGRSLGLYGKDQKEAALVDMVNDGVEDLRCKYGTLIYTNYENGKDDYVKALPGHLKPFETLLSQNQGGKAFIVGNQISFADYNLLDLLLVHQVLAPGCLDNFPLLSAYVARLSARPKIKAFLSSPDHLNRPINGNGKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPPYTIVYFPV ----CCCEEEEEEEC	11.83	-
46	Phosphorylation	WLQGSLKSTCLYGQL EECCCCCCCHHCCCC	29.64	23984901
47	Phosphorylation	LQGSLKSTCLYGQLP ECCCCCCCHHCCCCC	12.63	23984901
48	S-nitrosocysteine	QGSLKSTCLYGQLPK CCCCCCCHHCCCCCC	3.39	-
48	S-nitrosylation	QGSLKSTCLYGQLPK CCCCCCCHHCCCCCC	3.39	22178444
62	Phosphorylation	KFEDGDLTLYQSNAI CCCCCCEEEHHHHHH	28.32	23984901
76	Phosphorylation	ILRHLGRSLGLYGKD HHHHHHHHHCCCCCC	25.62	22673903
80	Phosphorylation	LGRSLGLYGKDQKEA HHHHHCCCCCCHHHH	21.97	22673903
82	Acetylation	RSLGLYGKDQKEAAL HHHCCCCCCHHHHHH	43.35	22902405
85	Acetylation	GLYGKDQKEAALVDM CCCCCCHHHHHHHHH	60.50	22902405
102	S-nitrosocysteine	DGVEDLRCKYGTLIY CCHHHHHHCCCEEEE	5.31	-
102	S-nitrosylation	DGVEDLRCKYGTLIY CCHHHHHHCCCEEEE	5.31	22178444
103	Acetylation	GVEDLRCKYGTLIYT CHHHHHHCCCEEEEE	40.04	25786129
103	Succinylation	GVEDLRCKYGTLIYT CHHHHHHCCCEEEEE	40.04	-
103	Succinylation	GVEDLRCKYGTLIYT CHHHHHHCCCEEEEE	40.04	-
104	Phosphorylation	VEDLRCKYGTLIYTN HHHHHHCCCEEEEEE	20.97	23984901
106	Phosphorylation	DLRCKYGTLIYTNYE HHHHCCCEEEEEECC	13.59	23984901
109	Phosphorylation	CKYGTLIYTNYENGK HCCCEEEEEECCCCC	7.64	23984901
116	Succinylation	YTNYENGKDDYVKAL EEECCCCCCCHHHHC	60.03	-
116	Succinylation	YTNYENGKDDYVKAL EEECCCCCCCHHHHC	60.03	-
128	Acetylation	KALPGHLKPFETLLS HHCCCCCCHHHHHHH	41.82	22902405
189	Acetylation	ARLSARPKIKAFLSS HHHHCCHHHHHHHCC	51.81	22902405
191	Acetylation	LSARPKIKAFLSSPD HHCCHHHHHHHCCCC	38.93	22902405
209	Acetylation	RPINGNGKQ------ CCCCCCCCC------	57.76	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4	Y	Phosphorylation	Kinase	EGFR	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTP1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GSTP1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.