ZBT38_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBT38_RAT
• UniProt AC: Q5EXX3
• Protein Name: Zinc finger and BTB domain-containing protein 38
• Gene Name: Zbtb38 {ECO:0000250|UniProtKB:Q8BW71}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1203
• Subcellular Localization: Nucleus . Chromosome . Localizes to chromocenters.
• Protein Description: Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner. Plays an important role in regulating DNA-replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (By similarity). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons. [PubMed: 15713629]
• Protein Sequence: MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVRRQETVTDLAAAGKRLGISFLEDLSDRNFSNSPGPYVVCITEKGVVKEEKNEKRHEEPAVTNGPRITNAFSIIETENSNSMFSPLDLRASFKKVSDAMRTTSLCQERASVCPEAEPVRTLAEHSYAVSSITEAYRSQPLREHDSSSSSGKTGKENGEALTTKAKPCRKPKTQTQDSDSTTENMPLPLVTCPEVNQERSPQPAPILSHSEPPSSEGDVHFPREDENQPSETPGPPAAEVPPLVYNCSCCSKSFDSSTLLGAHMQLHKPTQDPFVCKYCNKQFTTLNRLDRHEQICMRSSHMPMPGGNQPFLENYPTIGQDGGSFTSPDSLVPESRIGELSSAGSALSDADHMVKFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPTVYPYKLYRLLPMRCKRAPYKSYRNSSYESAQGNRQRNESPPDTFVIPNLPSSEMPTLNFQDGRNSLTSSPAIPVETPSWQGTPTSAKVKNAEGLKWRKQALKTDLVDSAEVSISSIGNSVSTTLQAEPVCVSSGEHSASVISYSGLVPSVIVHSSQFSSVIKHSNAIACLANSNHQSPSQPVASPSLIKDSKPEADKASKLASRPKNSKEKKKTVPCNRGEITEEAKYVADLGGSSGKTTNVVEETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAIVKRHILGSKLFYKRGRKPKYQMQEETLPRESDPETRGDSPLGLCQADCVEMSEAFDEVSDQDSTDKPWRPYYNYKPKKKSKQLRKIRKVKWRKERGSRSPVGRRRYPAELDRAEMGRRRYPAELDRCAEVKLPPDKASEEEENKEMPKLQCELCDGDKAAGAGAEGKPHQHLTLKPYICELCAKQFQSSSTLKMHMRCHTGEKPYQCKTCGRRFSVQGNLQKHERIHLGVKEFICQYCNKAFTLNETLKIHERIHTGEKRYHCQFCFQGFLYLSTKRNHERRHVREHDGKGFACFQCPKICKTAAALRMHQKKHLFKTLTKQEETDDLCHENSDLLESQPCTDSEDSDQKDDIKKPLLKMSFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
128	Phosphorylation	DLSDRNFSNSPGPYV HHCCCCCCCCCCCEE	39.69	27097102
130	Phosphorylation	SDRNFSNSPGPYVVC CCCCCCCCCCCEEEE	30.00	27097102
134	Phosphorylation	FSNSPGPYVVCITEK CCCCCCCEEEEEECC	16.07	27097102
181	Phosphorylation	ENSNSMFSPLDLRAS CCCCCCCCCHHHHHH	18.86	22673903
296	Phosphorylation	PEVNQERSPQPAPIL CCCCCCCCCCCCCCC	27.43	30181290
304	Phosphorylation	PQPAPILSHSEPPSS CCCCCCCCCCCCCCC	26.20	30181290
306	Phosphorylation	PAPILSHSEPPSSEG CCCCCCCCCCCCCCC	48.71	30181290
473	Phosphorylation	RSYVTLSSLRRHANV CCEEEHHHHHHHCCC	29.07	21630457
866	Phosphorylation	KYQMQEETLPRESDP CCCCCCCCCCCCCCC	41.11	25575281
871	Phosphorylation	EETLPRESDPETRGD CCCCCCCCCCCCCCC	60.80	25575281
875	Phosphorylation	PRESDPETRGDSPLG CCCCCCCCCCCCCCC	45.39	25575281
1049	Phosphorylation	EKPYQCKTCGRRFSV CCCEECCCCCCEEEE	28.02	25575281
1055	Phosphorylation	KTCGRRFSVQGNLQK CCCCCEEEEECCCCC	16.24	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBT38_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBT38_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBT38_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ZBT38_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.