MATR3_RAT - dbPTM
MATR3_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MATR3_RAT
UniProt AC P43244
Protein Name Matrin-3
Gene Name Matr3
Organism Rattus norvegicus (Rat).
Sequence Length 845
Subcellular Localization Nucleus matrix.
Protein Description May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins (By similarity)..
Protein Sequence MSKSFQQSSLGRDSQGHGRDLSAAGIGLLAAATQSLSMPASLGRMNQGTARLASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSRGPLPLSSQHRGDTDQASNILASFGLSARDLDELSRYPEDKITPENLPQILLQLKRRRTEEGPTLSYGRDGRSATREPPYRVPRDDWEEKRHFRRDSFDDRGPSLNPVLDYDHGSRSQESGYYDRMDYEDDRLRDGERCRDDSFFGETSHNYHKFDSEYERMGRGPGPLQERSLFEKKRGAPPSSNIEDFHGLLPKGYPHLCSICDLPVHSNKEWSQHINGASHSRRCQLLLEIYPEWNPDNDTGHTMGDPFMLQQSTNPAPGILGPPPPSFHLGGPAVGPRGNLGAGNGNLQGPRHMQKGRVETSRVVHIMDFQRGKNLRYQLLQLVEPFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQKYKRIKKPEGKPDEKFDQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEMETREDAMAMVDHCLKKALWFQGRCVKVDLSEKYKKLVLRIPNRGIDLLKKDKSRKRSYSPDGKESPSDKKSKTDGAQKTENPAEGKEQEEKSGEDGEKDTKDDQTEQEPSMLLESEDELLVDEEEAAALIESGSSVGDETDLANLGDVSSDGKKEPSDKAVKKDASATSKKKLKKVDKIEELDQENEAALENGIKNEENTEPGAESAENADDPNKDASDNSDGQNDENKEDYTIPDEYRIGPYQPNVPGGIDYVIPKTGFYCKLCSLFYTNEEVAKNTHCSSLPHYQKLKKFLNKLAEERRQKKES
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSKSFQQSS
------CCCCCCCHH		36.69-
3Acetylation-----MSKSFQQSSL
-----CCCCCCCHHC		54.73-
4Phosphorylation----MSKSFQQSSLG
----CCCCCCCHHCC		22.4527097102
8PhosphorylationMSKSFQQSSLGRDSQ
CCCCCCCHHCCCCCC		19.4223984901
9PhosphorylationSKSFQQSSLGRDSQG
CCCCCCHHCCCCCCC		30.4227097102
14PhosphorylationQSSLGRDSQGHGRDL
CHHCCCCCCCCCCCC		36.3828432305
22PhosphorylationQGHGRDLSAAGIGLL
CCCCCCCHHHHHHHH		21.9925403869
33PhosphorylationIGLLAAATQSLSMPA
HHHHHHHHHHHCCCH		17.6027097102
35PhosphorylationLLAAATQSLSMPASL
HHHHHHHHHCCCHHH		20.3227097102
37PhosphorylationAAATQSLSMPASLGR
HHHHHHHCCCHHHCC		28.1527097102
41PhosphorylationQSLSMPASLGRMNQG
HHHCCCHHHCCCCHH		26.0323984901
54PhosphorylationQGTARLASLMNLGMS
HHHHHHHHHHHHHCC		32.5123984901
61PhosphorylationSLMNLGMSSSLNQQG
HHHHHHCCCCCCHHC		18.2523984901
62PhosphorylationLMNLGMSSSLNQQGA
HHHHHCCCCCCHHCH		29.9223984901
63PhosphorylationMNLGMSSSLNQQGAH
HHHHCCCCCCHHCHH		24.8323984901
71PhosphorylationLNQQGAHSALSSAST
CCHHCHHHHHHCCCC		30.3023984901
74PhosphorylationQGAHSALSSASTSSH
HCHHHHHHCCCCCCC		24.4723984901
75PhosphorylationGAHSALSSASTSSHN
CHHHHHHCCCCCCCC		27.3923984901
77PhosphorylationHSALSSASTSSHNLQ
HHHHHCCCCCCCCHH		30.6723984901
78PhosphorylationSALSSASTSSHNLQS
HHHHCCCCCCCCHHH		33.6823984901
79PhosphorylationALSSASTSSHNLQSI
HHHCCCCCCCCHHHH		27.4023984901
80PhosphorylationLSSASTSSHNLQSIF
HHCCCCCCCCHHHHH		19.2423984901
85PhosphorylationTSSHNLQSIFNIGSR
CCCCCHHHHHCCCCC		32.1123984901
91PhosphorylationQSIFNIGSRGPLPLS
HHHHCCCCCCCCCCC		30.2123984901
105PhosphorylationSSQHRGDTDQASNIL
CCCCCCCCHHHHHHH		32.6027097102
109PhosphorylationRGDTDQASNILASFG
CCCCHHHHHHHHHCC		20.8323984901
114PhosphorylationQASNILASFGLSARD
HHHHHHHHCCCCHHC		19.1923984901
118PhosphorylationILASFGLSARDLDEL
HHHHCCCCHHCHHHH		22.9527097102
126PhosphorylationARDLDELSRYPEDKI
HHCHHHHHCCCCCCC		27.9323984901
146AcetylationPQILLQLKRRRTEEG
HHHHHHHHHHCCCCC		30.79149103
150PhosphorylationLQLKRRRTEEGPTLS
HHHHHHCCCCCCCCC		36.2627097102
155PhosphorylationRRTEEGPTLSYGRDG
HCCCCCCCCCCCCCC		38.9125575281
157PhosphorylationTEEGPTLSYGRDGRS
CCCCCCCCCCCCCCC		28.1927097102
158PhosphorylationEEGPTLSYGRDGRSA
CCCCCCCCCCCCCCC		21.2025575281
164PhosphorylationSYGRDGRSATREPPY
CCCCCCCCCCCCCCC		39.2525403869
166PhosphorylationGRDGRSATREPPYRV
CCCCCCCCCCCCCCC		36.4922673903
188PhosphorylationKRHFRRDSFDDRGPS
HHHHCCCCCCCCCCC		28.8523712012
195PhosphorylationSFDDRGPSLNPVLDY
CCCCCCCCCCCCCCC		43.5327097102
202PhosphorylationSLNPVLDYDHGSRSQ
CCCCCCCCCCCCCCC		12.9927097102
206PhosphorylationVLDYDHGSRSQESGY
CCCCCCCCCCCCCCC		25.9127097102
208PhosphorylationDYDHGSRSQESGYYD
CCCCCCCCCCCCCCC		39.7427097102
211PhosphorylationHGSRSQESGYYDRMD
CCCCCCCCCCCCCCC		25.1828432305
213PhosphorylationSRSQESGYYDRMDYE
CCCCCCCCCCCCCCC		16.0927097102
214PhosphorylationRSQESGYYDRMDYED
CCCCCCCCCCCCCCC		10.7027097102
219PhosphorylationGYYDRMDYEDDRLRD
CCCCCCCCCCCCCCC		16.35-
234PhosphorylationGERCRDDSFFGETSH
CCCCCCCCCCCCCCC		27.1128432305
264PhosphorylationPGPLQERSLFEKKRG
CCCHHHHHHHHHHCC		36.3423984901
275PhosphorylationKKRGAPPSSNIEDFH
HHCCCCCCCCHHHHH		34.6525403869
276PhosphorylationKRGAPPSSNIEDFHG
HCCCCCCCCHHHHHC		47.8325403869
289PhosphorylationHGLLPKGYPHLCSIC
HCCCCCCCCCEEECC		8.1323984901
294PhosphorylationKGYPHLCSICDLPVH
CCCCCEEECCCCCCC		32.3923984901
473AcetylationVRVHLSQKYKRIKKP
EEEEHHHHHHCCCCC		49.7322902405
506PhosphorylationHLSNLPHSGYSDSAV
EHHCCCCCCCCHHHH		37.1728432305
508PhosphorylationSNLPHSGYSDSAVLK
HCCCCCCCCHHHHHH		16.6023984901
509PhosphorylationNLPHSGYSDSAVLKL
CCCCCCCCHHHHHHH		28.7228432305
511PhosphorylationPHSGYSDSAVLKLAE
CCCCCCHHHHHHHHC		17.8423984901
522AcetylationKLAEPYGKIKNYILM
HHHCCCCHHHHHHHH		44.6722902405
533PhosphorylationYILMRMKSQAFIEME
HHHHHHHHCCEEEEC		19.8727097102
571AcetylationVKVDLSEKYKKLVLR
EEEECHHHHHHHHHH		60.02-
596PhosphorylationKDKSRKRSYSPDGKE
HCCCCCCCCCCCCCC		32.7629779826
597PhosphorylationDKSRKRSYSPDGKES
CCCCCCCCCCCCCCC		28.4027097102
598PhosphorylationKSRKRSYSPDGKESP
CCCCCCCCCCCCCCC		20.1228825834
604PhosphorylationYSPDGKESPSDKKSK
CCCCCCCCCCCCCCC		32.9423712012
606PhosphorylationPDGKESPSDKKSKTD
CCCCCCCCCCCCCCC		71.9323712012
610PhosphorylationESPSDKKSKTDGAQK
CCCCCCCCCCCCCCC		46.6725575281
612PhosphorylationPSDKKSKTDGAQKTE
CCCCCCCCCCCCCCC		46.9125575281
618PhosphorylationKTDGAQKTENPAEGK
CCCCCCCCCCHHCCH		28.9918779572
631PhosphorylationGKEQEEKSGEDGEKD
CHHHHHHCCCCCCCC		51.1729779826
639PhosphorylationGEDGEKDTKDDQTEQ
CCCCCCCCCCCCCCC		47.6522673903
644PhosphorylationKDTKDDQTEQEPSML
CCCCCCCCCCCHHHC		46.7822673903
649PhosphorylationDQTEQEPSMLLESED
CCCCCCHHHCCCCCC		22.7022673903
654PhosphorylationEPSMLLESEDELLVD
CHHHCCCCCCCEECC		50.7622673903
671PhosphorylationEAAALIESGSSVGDE
HHHHHHHCCCCCCCC		36.6622673903
673PhosphorylationAALIESGSSVGDETD
HHHHHCCCCCCCCCH		31.0022673903
674PhosphorylationALIESGSSVGDETDL
HHHHCCCCCCCCCHH		33.3822673903
679PhosphorylationGSSVGDETDLANLGD
CCCCCCCCHHHHHCC		40.8422673903
689PhosphorylationANLGDVSSDGKKEPS
HHHCCCCCCCCCCCC		50.67-
739PhosphorylationGIKNEENTEPGAESA
CCCCCCCCCCCHHHH		47.0022668510
745PhosphorylationNTEPGAESAENADDP
CCCCCHHHHHCCCCC		40.1122668510
757PhosphorylationDDPNKDASDNSDGQN
CCCCCCCCCCCCCCC		47.6722673903
760PhosphorylationNKDASDNSDGQNDEN
CCCCCCCCCCCCCCC		48.3721630457
771PhosphorylationNDENKEDYTIPDEYR
CCCCCCCCCCCCCCC		13.9922673903
772PhosphorylationDENKEDYTIPDEYRI
CCCCCCCCCCCCCCC		38.0522673903
777PhosphorylationDYTIPDEYRIGPYQP
CCCCCCCCCCCCCCC		18.2122673903
782PhosphorylationDEYRIGPYQPNVPGG
CCCCCCCCCCCCCCC		31.24-
792PhosphorylationNVPGGIDYVIPKTGF
CCCCCCCEEECCCCC		9.81-
800PhosphorylationVIPKTGFYCKLCSLF
EECCCCCEEEHHHHH		7.04-
834AcetylationKLKKFLNKLAEERRQ
HHHHHHHHHHHHHHH		51.7422902405
834UbiquitinationKLKKFLNKLAEERRQ
HHHHHHHHHHHHHHH		51.74-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MATR3_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MATR3_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MATR3_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MATR3_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MATR3_RAT

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites.";
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, AND MASSSPECTROMETRY.
"Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS.";
Moser K., White F.M.;
J. Proteome Res. 5:98-104(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-598, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory