HNRH2_RAT - dbPTM
HNRH2_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HNRH2_RAT
UniProt AC Q6AY09
Protein Name Heterogeneous nuclear ribonucleoprotein H2
Gene Name Hnrnph2
Organism Rattus norvegicus (Rat).
Sequence Length 449
Subcellular Localization Nucleus, nucleoplasm.
Protein Description This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity)..
Protein Sequence MMLSTEGREGFVVKVRGLPWSCSAEEVMRFFSDCKIQNGTSGVRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNSVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGMTLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMTMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYGGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSSFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPMRVHIEIGPDGRVTGEADVEFATHEDAVAAMAKDKANMQHRYVELFLNSTAGTSGGAYDHSYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSAGYGGGYGGQSSMSGYDQVLQENSSDYQSNLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MMLSTEGR
-------CCCCCCCC		5.71-
2Acetylation------MMLSTEGRE
------CCCCCCCCC		3.99-
23PhosphorylationRGLPWSCSAEEVMRF
ECCCCCCCHHHHHHH		32.95-
35UbiquitinationMRFFSDCKIQNGTSG
HHHHHCCEEECCCCC		52.93-
54PhosphorylationYTREGRPSGEAFVEL
EEECCCCCCCEEEEE		48.1522817900
63PhosphorylationEAFVELESEDEVKLA
CEEEEECCHHHHEEE		64.0727097102
90PhosphorylationVEVFKSNSVEMDWVL
EEEHHCCCEEEEEEE		26.92-
100PhosphorylationMDWVLKHTGPNSPDT
EEEEEECCCCCCCCC		53.3923712012
104PhosphorylationLKHTGPNSPDTANDG
EECCCCCCCCCCCCC		27.5623712012
107PhosphorylationTGPNSPDTANDGFVR
CCCCCCCCCCCCCEE		30.6423712012
151PhosphorylationPVDFQGRSTGEAFVQ
CCCCCCCCHHHHHHH		47.8123984901
152PhosphorylationVDFQGRSTGEAFVQF
CCCCCCCHHHHHHHH		37.3723984901
161PhosphorylationEAFVQFASQEIAEKA
HHHHHHHHHHHHHHH		29.6323984901
167AcetylationASQEIAEKALKKHKE
HHHHHHHHHHHHHHH		50.4225786129
210PhosphorylationTMQRPGPYDRPGAGR
CCCCCCCCCCCCCCC		30.4221630457
219PhosphorylationRPGAGRGYNSIGRGA
CCCCCCCCCCCCCCC		12.3621630457
221PhosphorylationGAGRGYNSIGRGAGF
CCCCCCCCCCCCCCH		20.2421630457
224MethylationRGYNSIGRGAGFERM
CCCCCCCCCCCHHHH		30.0725057135
233MethylationAGFERMRRGAYGGGY
CCHHHHHCCCCCCCC		25.4212018905
246PhosphorylationGYGGYDDYGGYNDGY
CCCCCCCCCCCCCCC		15.00-
266PhosphorylationRFGRDLNYCFSGMSD
CCCCCCCCCCCCCCC		11.36-
269PhosphorylationRDLNYCFSGMSDHRY
CCCCCCCCCCCCCCC		29.9928432305
272PhosphorylationNYCFSGMSDHRYGDG
CCCCCCCCCCCCCCC		33.5228432305
281PhosphorylationHRYGDGGSSFQSTTG
CCCCCCCCCCCCCCC		33.2425575281
282PhosphorylationRYGDGGSSFQSTTGH
CCCCCCCCCCCCCCC		30.4922668510
285PhosphorylationDGGSSFQSTTGHCVH
CCCCCCCCCCCCCEE		26.4025575281
286PhosphorylationGGSSFQSTTGHCVHM
CCCCCCCCCCCCEEE		26.4725575281
287PhosphorylationGSSFQSTTGHCVHMR
CCCCCCCCCCCEEEC		30.1225575281
306PhosphorylationRATENDIYNFFSPLN
CCCCCCCHHCCCCCC		14.5830181290
310PhosphorylationNDIYNFFSPLNPMRV
CCCHHCCCCCCCCEE		25.0827097102
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HNRH2_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HNRH2_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HNRH2_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HNRH2_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HNRH2_RAT

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites.";
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, AND MASSSPECTROMETRY.

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