HNRPF_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HNRPF_RAT
• UniProt AC: Q794E4
• Protein Name: Heterogeneous nuclear ribonucleoprotein F
• Gene Name: Hnrnpf
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 415
• Subcellular Localization: Nucleus, nucleoplasm .
• Protein Description: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity)..
• Protein Sequence: MMLGPEGGEGYVVKLRGLPWSCSIEDVQNFLSDCTIHDGVAGVHFIYTREGRQSGEAFVELESEDDVKLALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLDRMRSGAYSAGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGLESQSVSGCYGAGYSGQNSMGGYD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMLGPEGG -------CCCCCCCC	4.52	-
2	Acetylation	------MMLGPEGGE ------CCCCCCCCC	6.27	-
14	Acetylation	GGEGYVVKLRGLPWS CCCCEEEEECCCCCC	23.56	22902405
21	Phosphorylation	KLRGLPWSCSIEDVQ EECCCCCCCCHHHHH	8.96	23984901
23	Phosphorylation	RGLPWSCSIEDVQNF CCCCCCCCHHHHHHH	24.40	23984901
63	Phosphorylation	EAFVELESEDDVKLA EEEEEECCHHHHHHH	59.97	23984901
87	Ubiquitination	HRYIEVFKSHRTEMD HHHHHHHHHCHHHCE	50.99	-
87	Acetylation	HRYIEVFKSHRTEMD HHHHHHHHHCHHHCE	50.99	22902405
98	Acetylation	TEMDWVLKHSGPNSA HHCEEHHHCCCCCCC	26.55	30595335
98	Ubiquitination	TEMDWVLKHSGPNSA HHCEEHHHCCCCCCC	26.55	-
100	Phosphorylation	MDWVLKHSGPNSADS CEEHHHCCCCCCCCC	55.12	27097102
104	Phosphorylation	LKHSGPNSADSANDG HHCCCCCCCCCCCCC	36.26	27097102
107	Phosphorylation	SGPNSADSANDGFVR CCCCCCCCCCCCCEE	28.78	27097102
161	Phosphorylation	EAFVQFASQELAEKA HHHHHHHCHHHHHHH	26.02	23984901
186	Phosphorylation	RYIEVFKSSQEEVRS HHHHHHHCCHHHHHH	26.28	22673903
187	Phosphorylation	YIEVFKSSQEEVRSY HHHHHHCCHHHHHHC	42.05	22673903
193	Phosphorylation	SSQEEVRSYSDPPLK CCHHHHHHCCCCCCE	33.88	-
195	Phosphorylation	QEEVRSYSDPPLKFM HHHHHHCCCCCCEEE	44.91	22673903
200	Acetylation	SYSDPPLKFMSVQRP HCCCCCCEEEEECCC	44.81	-
215	Phosphorylation	GPYDRPGTARRYIGI CCCCCCCCHHHHHHH	21.48	-
224	Ubiquitination	RRYIGIVKQAGLDRM HHHHHHHHHHCHHHH	32.29	-
224	Acetylation	RRYIGIVKQAGLDRM HHHHHHHHHHCHHHH	32.29	22902405
265	Phosphorylation	DLFGRDLSYCLSGMY HHCCCCHHHHHHCCC	20.35	22276854
299	Acetylation	HMRGLPYKATENDIY EECCCCCCCCCCCCH	47.06	72592479
306	Phosphorylation	KATENDIYNFFSPLN CCCCCCCHHCCCCCC	14.58	25403869
310	Phosphorylation	NDIYNFFSPLNPVRV CCCHHCCCCCCCEEE	25.08	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HNRPF_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HNRPF_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HNRPF_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of HNRPF_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.