HSP74_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSP74_RAT
• UniProt AC: O88600
• Protein Name: Heat shock 70 kDa protein 4
• Gene Name: Hspa4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 840
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSVGAAAKSQVISNAKNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAESVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKVRALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSILDQSKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFPKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETDQNAKEEEKMQVDQEEPHTEEQQPQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLPIESQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDRNNFTLKLEDTENWLYEDGEDQPKQVYVDKLAELRTLGQPIKTRFQESEERPKLFEELGKQIQQYMKVISSFKNKEDQYEHLDAADMTKVEKSTNEAMEWMNSKLNLQNKQSLTADPVVKTKEIEAKIKELTNICSPIISKPKPKVEPPKEEPKHAEQNGPVDGQGDNPGTQAAEHGADTAVPSDGDKKLPEMDID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	RCTPACVSFGPKNRS CCCHHHHCCCCCCCC	25.11	23984901
53	Acetylation	RSVGAAAKSQVISNA CCCCHHHHHHHHHCC	36.37	-
63	Phosphorylation	VISNAKNTVQGFKRF HHHCCCHHHHHHHHH	17.31	23984901
76	Phosphorylation	RFHGRAFSDPFVEAE HHCCCCCCCCCHHHH	43.31	23589303
89	Phosphorylation	AEKSNLAYDIVQLPT HHHCCCCEEEEECCC	14.90	-
184	Phosphorylation	VALAYGIYKQDLPAL HHHHHCHHHCCCHHH	9.76	-
229	Phosphorylation	VLATAFDTTLGGRKF EEEEEECCCCCCCCH	19.91	23984901
230	Phosphorylation	LATAFDTTLGGRKFD EEEEECCCCCCCCHH	25.83	23984901
253	Acetylation	EEFGKKYKLDIKSKV HHHCHHCCCCHHHHH	48.87	22902405
257	Acetylation	KKYKLDIKSKVRALL HHCCCCHHHHHHHHH	43.84	22902405
272	Acetylation	RLSQECEKLKKLMSA HHHHHHHHHHHHHHC	76.81	22902405
336	Phosphorylation	KLKKEDIYAVEIVGG HCCCCCEEEEEEECC	19.54	-
356	Acetylation	AVKEKISKFFGKELS HHHHHHHHHHCCHHH	48.46	22902405
384	Phosphorylation	ALQCAILSPAFKVRE HHHHHHHCCCEEEEE	14.20	23984901
388	Ubiquitination	AILSPAFKVREFSIT HHHCCCEEEEEEECC	42.35	-
393	Phosphorylation	AFKVREFSITDVVPY CEEEEEEECCEEEEC	21.59	23984901
395	Phosphorylation	KVREFSITDVVPYPI EEEEEECCEEEECCC	22.88	23984901
408	Phosphorylation	PISLRWNSPAEEGSS CCEEECCCCCCCCCC	20.66	23984901
414	Phosphorylation	NSPAEEGSSDCEVFP CCCCCCCCCCCEECC	26.70	28432305
415	Phosphorylation	SPAEEGSSDCEVFPK CCCCCCCCCCEECCC	58.08	28432305
417	S-nitrosocysteine	AEEGSSDCEVFPKNH CCCCCCCCEECCCCC	5.33	-
417	S-nitrosylation	AEEGSSDCEVFPKNH CCCCCCCCEECCCCC	5.33	19101475
430	Acetylation	NHAAPFSKVLTFYRK CCCCCHHHHEEEECC	41.46	22902405
477	Acetylation	QSDGSSSKVKVKVRV CCCCCCCCEEEEEEE	48.28	25786129
494	Phosphorylation	HGIFSVSSAALVEVH EEEEEECCEEEEEEC	18.53	30240740
531	Phosphorylation	VDQEEPHTEEQQPQT CCCCCCCCCCCCCCC	52.51	23984901
538	Phosphorylation	TEEQQPQTPAENKAE CCCCCCCCCCCCHHH	31.02	23712012
546	Phosphorylation	PAENKAESEEMETSQ CCCCHHHHHHHHHHC	43.65	23298284
551	Phosphorylation	AESEEMETSQAGSKD HHHHHHHHHCCCCCC	25.48	23984901
552	Phosphorylation	ESEEMETSQAGSKDK HHHHHHHHCCCCCCC	12.53	28432305
556	Phosphorylation	METSQAGSKDKKMDQ HHHHCCCCCCCCCCC	40.47	28432305
609	Acetylation	GKMIMQDKLEKERND CCCCCHHHHHHHHHH	41.47	22902405
631	Acetylation	YVYEMRDKLSGEYEK HHHHHHHHCCCHHHH	33.90	22902405
660	Phosphorylation	EDTENWLYEDGEDQP EECCCCEECCCCCCC	12.00	-
668	Acetylation	EDGEDQPKQVYVDKL CCCCCCCCEEEHHHH	46.92	22902405
674	Acetylation	PKQVYVDKLAELRTL CCEEEHHHHHHHHHC	39.28	22902405
692	Phosphorylation	IKTRFQESEERPKLF HHHCCCCCHHHHHHH	33.69	25403869
704	Acetylation	KLFEELGKQIQQYMK HHHHHHHHHHHHHHH	57.78	22902405
719	Acetylation	VISSFKNKEDQYEHL HHHHCCCCHHHHHCC	64.36	22902405
733	Acetylation	LDAADMTKVEKSTNE CCHHHHHHHHHHHHH	41.58	22902405
754	Ubiquitination	SKLNLQNKQSLTADP HHHCCCCCCCCCCCC	28.44	-
756	Phosphorylation	LNLQNKQSLTADPVV HCCCCCCCCCCCCCC	29.33	-
773	Methylation	KEIEAKIKELTNICS HHHHHHHHHHHCCCC	46.06	-
776	Phosphorylation	EAKIKELTNICSPII HHHHHHHHCCCCCHH	24.51	30181290
780	Phosphorylation	KELTNICSPIISKPK HHHHCCCCCHHCCCC	18.48	28432305
784	Phosphorylation	NICSPIISKPKPKVE CCCCCHHCCCCCCCC	43.56	28432305
815	Phosphorylation	GQGDNPGTQAAEHGA CCCCCCCCHHHHCCC	19.11	27097102
824	Phosphorylation	AAEHGADTAVPSDGD HHHCCCCCCCCCCCC	29.08	27097102
828	Phosphorylation	GADTAVPSDGDKKLP CCCCCCCCCCCCCCC	47.85	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSP74_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSP74_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSP74_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG1_RAT	Bag1	physical	16116448

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.