TCPG_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPG_RAT
• UniProt AC: Q6P502
• Protein Name: T-complex protein 1 subunit gamma
• Gene Name: Cct3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 545
• Subcellular Localization: Cytoplasm.
• Protein Description: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Plays a role in the assembly of the von Hippel-Lindau ubiquitination complex (By similarity). Interacts with DNAAF4 (By similarity)..
• Protein Sequence: MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDDMVSTLKKISTPVDVNNRDMMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQNRQTGAPDAGQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMGHRPVL -------CCCCCCEE	7.01	-
11	Phosphorylation	HRPVLVLSQNTKRES CCCEEEEECCCCCCC	17.57	-
138	Acetylation	DDMVSTLKKISTPVD HHHHHHHHHCCCCCC	48.42	22902405
169	Phosphorylation	TKVISRWSSLACNIA HHHHHHHHHHHHHHH	17.86	23984901
170	Phosphorylation	KVISRWSSLACNIAL HHHHHHHHHHHHHHH	17.02	23984901
196	Acetylation	GRKEIDIKKYARVEK CEEEEEHHHEEEEEE	35.66	22902405
222	Acetylation	LRGVMINKDVTHPRM EECEEECCCCCCHHH	42.52	22902405
234	Acetylation	PRMRRYIKNPRIVLL HHHHHHCCCCCEEEE	52.55	22902405
243	Phosphorylation	PRIVLLDSSLEYKKG CCEEEEECCCCCCCC	36.47	28432305
244	Phosphorylation	RIVLLDSSLEYKKGE CEEEEECCCCCCCCC	25.53	28432305
247	Phosphorylation	LLDSSLEYKKGESQT EEECCCCCCCCCCCC	24.24	23984901
248	Acetylation	LDSSLEYKKGESQTD EECCCCCCCCCCCCC	44.95	22902405
252	Phosphorylation	LEYKKGESQTDIEIT CCCCCCCCCCCCEEE	47.23	19947656
254	Phosphorylation	YKKGESQTDIEITRE CCCCCCCCCCEEECH	48.50	28432305
259	Phosphorylation	SQTDIEITREEDFTR CCCCCEEECHHHHHH	21.16	25575281
381	Acetylation	ILLRGASKEILSEVE EEECCCCHHHHHHHH	48.52	22902405
381	Ubiquitination	ILLRGASKEILSEVE EEECCCCHHHHHHHH	48.52	-
430	Phosphorylation	TEKSKAMTGVEQWPY HHHCCCCCCCCCCHH	42.82	-
458	Phosphorylation	LIQNCGASTIRLLTS HHHHCCHHHHHHHHH	15.06	23984901
459	Phosphorylation	IQNCGASTIRLLTSL HHHCCHHHHHHHHHH	15.02	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCPG_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPG_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPG_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TCPG_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.