WDR1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR1_RAT
• UniProt AC: Q5RKI0
• Protein Name: WD repeat-containing protein 1
• Gene Name: Wdr1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 606
• Subcellular Localization: Cytoplasm, cytoskeleton . Cell projection, podosome .
• Protein Description: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity)..
• Protein Sequence: MPYEIKKVFASLPQVERGVSKILGGDPKGDNFLYTNGKCVILRNIDNPAVADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHILKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDTGSSVGEITGHNKVINSVDIKQNRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGSNVLDQQLGCLWQKDHLLSISLSGYINYLDKNNPSKPLRVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFSGKGHTNQVSRMTVDESGQLVSCSMDDTVRYTNLTLRDYSGQGVVKLDVQPKCVAVGPGGYTVVVCIGQIVLLKDQKKCFSIDNPGYEPEVVAVHPGGDTVAVGGSDGNVRVYSILGATLKDEGKLLEAKGPVTDLAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETKVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Acetylation	KILGGDPKGDNFLYT HHHCCCCCCCCCEEE	81.35	22902405
34	Phosphorylation	PKGDNFLYTNGKCVI CCCCCCEEECCEEEE	8.27	-
81	Acetylation	ASGDISGKLRIWDTT EECCCCCCEEEEECC	28.00	22902405
90	Acetylation	RIWDTTQKEHILKYE EEEECCCCEEEEEEE	49.52	26302492
95	Acetylation	TQKEHILKYEYQPFA CCCEEEEEEECCCCC	35.12	22902405
104	Acetylation	EYQPFAGKIKDIAWT ECCCCCCCCEEEEEC	43.06	22902405
106	Acetylation	QPFAGKIKDIAWTED CCCCCCCEEEEECCC	46.71	22902405
115	Acetylation	IAWTEDSKRIAVVGE EEECCCCCEEEEEEC	61.21	22902405
182	Acetylation	EGPPFKFKFTIGDHS CCCCEEEEEEECCCC	42.03	22902405
219	Acetylation	QIFIYDGKTGEKVCA EEEEECCCCCCEEEE	50.92	22902405
230	Phosphorylation	KVCALGGSKAHDGGI EEEECCCCCCCCCCE	25.52	25575281
238	Phosphorylation	KAHDGGIYAISWSPD CCCCCCEEEEEECCC	10.93	25575281
241	Phosphorylation	DGGIYAISWSPDSTH CCCEEEEEECCCCCC	17.21	25575281
243	Phosphorylation	GIYAISWSPDSTHLL CEEEEEECCCCCCEE	16.43	25575281
246	Phosphorylation	AISWSPDSTHLLSAS EEEECCCCCCEEECC	22.55	25575281
247	Phosphorylation	ISWSPDSTHLLSASG EEECCCCCCEEECCC	24.75	25575281
256	Acetylation	LLSASGDKTSKIWDV EEECCCCCCCCEEEE	59.22	22902405
362	Acetylation	ENDSFSGKGHTNQVS CCCCCCCCCCCCCEE	46.45	22902405
405	Acetylation	YSGQGVVKLDVQPKC CCCCCEEEEEEECCE	36.24	22902405
405	Ubiquitination	YSGQGVVKLDVQPKC CCCCCEEEEEEECCE	36.24	-
480	Acetylation	SILGATLKDEGKLLE EEEECEECCCCEEEE	49.75	22902405
569	Acetylation	SDPETKVKIQDAHRL CCCCCEEEEEHHHHH	35.88	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of WDR1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.