PHB2_RAT - dbPTM
PHB2_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHB2_RAT
UniProt AC Q5XIH7
Protein Name Prohibitin-2
Gene Name Phb2 {ECO:0000250|UniProtKB:Q99623}
Organism Rattus norvegicus (Rat).
Sequence Length 299
Subcellular Localization Mitochondrion inner membrane . Cytoplasm . Nucleus .
Protein Description Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity)..
Protein Sequence MAQNLKDLAGRLPSGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQDESFTRGSDSLIKGKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAQNLKDLA
------CCCCHHHHH		13.63-
39O-linked_GlycosylationVAYGVRESVFTVEGG
HCCEEECCEEEEECC		16.3927213235
77PhosphorylationFRIPWFQYPIIYDIR
EECCCCCCCEEEEEC		6.21-
89SuccinylationDIRARPRKISSPTGS
EECCCCCCCCCCCCC		50.0126843850
91PhosphorylationRARPRKISSPTGSKD
CCCCCCCCCCCCCCC		33.0429779826
92PhosphorylationARPRKISSPTGSKDL
CCCCCCCCCCCCCCC		29.9228432305
97AcetylationISSPTGSKDLQMVNI
CCCCCCCCCCEEEEE		64.9022902405
105PhosphorylationDLQMVNISLRVLSRP
CCEEEEEEEEEHHCC		12.6223984901
119PhosphorylationPNAQELPSMYQRLGL
CCHHHCCHHHHHHCC		42.6223991683
121PhosphorylationAQELPSMYQRLGLDY
HHHCCHHHHHHCCCH		8.5323991683
128PhosphorylationYQRLGLDYEERVLPS
HHHHCCCHHHCHHHH		25.40-
135O-linked_GlycosylationYEERVLPSIVNEVLK
HHHCHHHHHHHHHHH		34.7027213235
142AcetylationSIVNEVLKSVVAKFN
HHHHHHHHHHHHHCC		46.5122902405
147AcetylationVLKSVVAKFNASQLI
HHHHHHHHCCHHHHH		27.7822902405
151PhosphorylationVVAKFNASQLITQRA
HHHHCCHHHHHHHHH		26.9923991683
155PhosphorylationFNASQLITQRAQVSL
CCHHHHHHHHHHHHH		22.1623991683
161PhosphorylationITQRAQVSLLIRREL
HHHHHHHHHHHHHHH		12.8423991683
161O-linked_GlycosylationITQRAQVSLLIRREL
HHHHHHHHHHHHHHH		12.8427213235
169PhosphorylationLLIRRELTERAKDFS
HHHHHHHHHHHHHCE		20.7623991683
200AcetylationYTAAVEAKQVAQQEA
HHHHHHHHHHHHHHH		31.6222902405
216AcetylationRAQFLVEKAKQEQRQ
HHHHHHHHHHHHHHH		54.1022902405
236AcetylationEGEAEAAKMLGEALS
HHHHHHHHHHHHHHH		41.5322902405
243PhosphorylationKMLGEALSKNPGYIK
HHHHHHHHHCCCCCH		37.1223991683
244AcetylationMLGEALSKNPGYIKL
HHHHHHHHCCCCCHH		68.9322902405
248PhosphorylationALSKNPGYIKLRKIR
HHHHCCCCCHHHHHH		8.99-
250AcetylationSKNPGYIKLRKIRAA
HHCCCCCHHHHHHHH		33.4822902405
262AcetylationRAAQNISKTIATSQN
HHHHHHCHHHHCCCC		39.90-
266PhosphorylationNISKTIATSQNRIYL
HHCHHHHCCCCEEEE		27.3123991683
267PhosphorylationISKTIATSQNRIYLT
HCHHHHCCCCEEEEE		19.2123991683
286PhosphorylationVLNLQDESFTRGSDS
EEECCCCCCCCCCCC		39.9623984901
288PhosphorylationNLQDESFTRGSDSLI
ECCCCCCCCCCCCCC		43.3223984901
291PhosphorylationDESFTRGSDSLIKGK
CCCCCCCCCCCCCCC		22.2723991683
293PhosphorylationSFTRGSDSLIKGKK-
CCCCCCCCCCCCCC-		33.4229779826
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHB2_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHB2_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHB2_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PHB2_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHB2_RAT

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Related Literatures of Post-Translational Modification

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