MDHM_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MDHM_RAT
• UniProt AC: P04636
• Protein Name: Malate dehydrogenase, mitochondrial
• Gene Name: Mdh2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 338
• Subcellular Localization: Mitochondrion matrix .
• Protein Sequence: MLSALARPVGAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETRANVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICIISNPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLATLTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVIECSFVQSKETECTYFSTPLLLGKKGLEKNLGIGKITPFEEKMIAEAIPELKASIKKGEDFVKNMK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	O-linked_Glycosylation	KVAVLGASGGIGQPL EEEEEECCCCCCHHH	35.44	27213235
33	Phosphorylation	KVAVLGASGGIGQPL EEEEEECCCCCCHHH	35.44	23984901
47	Phosphorylation	LSLLLKNSPLVSRLT HHHHHHCCCCCEEEE	20.30	23984901
51	Phosphorylation	LKNSPLVSRLTLYDI HHCCCCCEEEEHHHH	29.29	23991683
51	O-linked_Glycosylation	LKNSPLVSRLTLYDI HHCCCCCEEEEHHHH	29.29	27213235
54	Phosphorylation	SPLVSRLTLYDIAHT CCCCEEEEHHHHCCC	23.35	23984901
56	Phosphorylation	LVSRLTLYDIAHTPG CCEEEEHHHHCCCCC	10.48	23991683
61	Phosphorylation	TLYDIAHTPGVAADL EHHHHCCCCCHHHCC	16.83	23984901
69	O-linked_Glycosylation	PGVAADLSHIETRAN CCHHHCCHHCHHHCC	23.98	27213235
78	Succinylation	IETRANVKGYLGPEQ CHHHCCCCCCCCHHH	41.46	26843850
78	Acetylation	IETRANVKGYLGPEQ CHHHCCCCCCCCHHH	41.46	22902405
78	Succinylation	IETRANVKGYLGPEQ CHHHCCCCCCCCHHH	41.46	-
80	Phosphorylation	TRANVKGYLGPEQLP HHCCCCCCCCHHHCC	11.63	-
91	Succinylation	EQLPDCLKGCDVVVI HHCCHHHCCCCEEEE	64.92	-
91	Acetylation	EQLPDCLKGCDVVVI HHCCHHHCCCCEEEE	64.92	22902405
91	Succinylation	EQLPDCLKGCDVVVI HHCCHHHCCCCEEEE	64.92	-
105	Acetylation	IPAGVPRKPGMTRDD ECCCCCCCCCCCHHH	39.59	22902405
157	Acetylation	ITAEVFKKHGVYNPN EEHHHHHHCCCCCCC	33.84	22902405
157	Succinylation	ITAEVFKKHGVYNPN EEHHHHHHCCCCCCC	33.84	26843850
165	Acetylation	HGVYNPNKIFGVTTL CCCCCCCCEEEEEHH	40.44	22902405
170	O-linked_Glycosylation	PNKIFGVTTLDIVRA CCCEEEEEHHHHHHH	23.24	27213235
170	Phosphorylation	PNKIFGVTTLDIVRA CCCEEEEEHHHHHHH	23.24	23984901
171	Phosphorylation	NKIFGVTTLDIVRAN CCEEEEEHHHHHHHC	21.74	23984901
185	Acetylation	NTFVAELKGLDPARV CCHHHHHCCCCHHHE	49.27	25786129
185	Succinylation	NTFVAELKGLDPARV CCHHHHHCCCCHHHE	49.27	-
185	Succinylation	NTFVAELKGLDPARV CCHHHHHCCCCHHHE	49.27	26843850
203	Succinylation	VIGGHAGKTIIPLIS EECCCCCCCHHHHHH	37.02	-
203	Acetylation	VIGGHAGKTIIPLIS EECCCCCCCHHHHHH	37.02	22902405
203	Succinylation	VIGGHAGKTIIPLIS EECCCCCCCHHHHHH	37.02	-
213	Phosphorylation	IPLISQCTPKVDFPQ HHHHHHCCCCCCCCH	20.64	23991683
215	Acetylation	LISQCTPKVDFPQDQ HHHHCCCCCCCCHHH	35.96	22902405
215	Succinylation	LISQCTPKVDFPQDQ HHHHCCCCCCCCHHH	35.96	-
215	Succinylation	LISQCTPKVDFPQDQ HHHHCCCCCCCCHHH	35.96	-
225	Phosphorylation	FPQDQLATLTGRIQE CCHHHHHHHHHHHHH	33.18	30181290
227	Phosphorylation	QDQLATLTGRIQEAG HHHHHHHHHHHHHHC	21.76	30181290
227	O-linked_Glycosylation	QDQLATLTGRIQEAG HHHHHHHHHHHHHHC	21.76	27213235
235	Phosphorylation	GRIQEAGTEVVKAKA HHHHHHCCEEEHHCC	32.43	23991683
239	Acetylation	EAGTEVVKAKAGAGS HHCCEEEHHCCCCCC	49.71	25786129
239	Malonylation	EAGTEVVKAKAGAGS HHCCEEEHHCCCCCC	49.71	-
239	N6-malonyllysine	EAGTEVVKAKAGAGS HHCCEEEHHCCCCCC	49.71	-
239	Succinylation	EAGTEVVKAKAGAGS HHCCEEEHHCCCCCC	49.71	-
246	Phosphorylation	KAKAGAGSATLSMAY HHCCCCCCHHHHHHH	19.97	23991683
248	Phosphorylation	KAGAGSATLSMAYAG CCCCCCHHHHHHHHH	22.51	23991683
250	O-linked_Glycosylation	GAGSATLSMAYAGAR CCCCHHHHHHHHHHH	9.30	27213235
250	Phosphorylation	GAGSATLSMAYAGAR CCCCHHHHHHHHHHH	9.30	23991683
253	Phosphorylation	SATLSMAYAGARFVF CHHHHHHHHHHHHHH	9.27	23991683
269	Succinylation	LVDAMNGKEGVIECS HHHHHCCCCCEEEEE	46.41	-
269	Succinylation	LVDAMNGKEGVIECS HHHHHCCCCCEEEEE	46.41	-
281	Acetylation	ECSFVQSKETECTYF EEEEEECCCCCCEEE	52.11	26302492
283	Phosphorylation	SFVQSKETECTYFST EEEECCCCCCEEEEC	39.85	22673903
286	Phosphorylation	QSKETECTYFSTPLL ECCCCCCEEEECCHH	22.75	22673903
287	Phosphorylation	SKETECTYFSTPLLL CCCCCCEEEECCHHC	13.75	22673903
289	Phosphorylation	ETECTYFSTPLLLGK CCCCEEEECCHHCCC	20.78	22673903
290	Phosphorylation	TECTYFSTPLLLGKK CCCEEEECCHHCCCC	14.20	22673903
296	Acetylation	STPLLLGKKGLEKNL ECCHHCCCCCHHHCC	43.57	25786129
296	Succinylation	STPLLLGKKGLEKNL ECCHHCCCCCHHHCC	43.57	-
296	Succinylation	STPLLLGKKGLEKNL ECCHHCCCCCHHHCC	43.57	-
297	Acetylation	TPLLLGKKGLEKNLG CCHHCCCCCHHHCCC	67.91	22902405
301	Succinylation	LGKKGLEKNLGIGKI CCCCCHHHCCCCCCC	63.62	26843850
301	Acetylation	LGKKGLEKNLGIGKI CCCCCHHHCCCCCCC	63.62	25786129
301	Succinylation	LGKKGLEKNLGIGKI CCCCCHHHCCCCCCC	63.62	-
307	Malonylation	EKNLGIGKITPFEEK HHCCCCCCCCHHHHH	41.30	-
307	Succinylation	EKNLGIGKITPFEEK HHCCCCCCCCHHHHH	41.30	26843850
307	Acetylation	EKNLGIGKITPFEEK HHCCCCCCCCHHHHH	41.30	22902405
307	N6-malonyllysine	EKNLGIGKITPFEEK HHCCCCCCCCHHHHH	41.30	-
309	Phosphorylation	NLGIGKITPFEEKMI CCCCCCCCHHHHHHH	25.97	23984901
314	Acetylation	KITPFEEKMIAEAIP CCCHHHHHHHHHHHH	28.54	22902405
314	Succinylation	KITPFEEKMIAEAIP CCCHHHHHHHHHHHH	28.54	26843850
314	Succinylation	KITPFEEKMIAEAIP CCCHHHHHHHHHHHH	28.54	-
324	Succinylation	AEAIPELKASIKKGE HHHHHHHHHHHHCCH	38.12	26843850
324	Acetylation	AEAIPELKASIKKGE HHHHHHHHHHHHCCH	38.12	22902405
324	Succinylation	AEAIPELKASIKKGE HHHHHHHHHHHHCCH	38.12	-
326	Phosphorylation	AIPELKASIKKGEDF HHHHHHHHHHCCHHH	33.10	25575281
328	Acetylation	PELKASIKKGEDFVK HHHHHHHHCCHHHHH	52.83	22902405
328	Succinylation	PELKASIKKGEDFVK HHHHHHHHCCHHHHH	52.83	-
328	Succinylation	PELKASIKKGEDFVK HHHHHHHHCCHHHHH	52.83	-
329	Malonylation	ELKASIKKGEDFVKN HHHHHHHCCHHHHHH	66.90	-
329	Acetylation	ELKASIKKGEDFVKN HHHHHHHCCHHHHHH	66.90	22902405
329	N6-malonyllysine	ELKASIKKGEDFVKN HHHHHHHCCHHHHHH	66.90	-
329	Succinylation	ELKASIKKGEDFVKN HHHHHHHCCHHHHHH	66.90	26843850
335	Succinylation	KKGEDFVKNMK---- HCCHHHHHHCC----	51.85	-
335	Succinylation	KKGEDFVKNMK---- HCCHHHHHHCC----	51.85	-
335	Acetylation	KKGEDFVKNMK---- HCCHHHHHHCC----	51.85	25786129
338	Acetylation	EDFVKNMK------- HHHHHHCC-------	67.59	26302492

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MDHM_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MDHM_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MDHM_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MDHM_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.