K2C5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C5_RAT
• UniProt AC: Q6P6Q2
• Protein Name: Keratin, type II cytoskeletal 5
• Gene Name: Krt5 {ECO:0000250|UniProtKB:P13647}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 576
• Protein Sequence: MSRQSSVSFRSGGSRSFSAASAITPSVSRTTFSSVSRSGGGGGRVSLGGAYGAGGYGSRSLYNVGGSKRISFSSGGGSFRNQFGAGAGGGYGFGGGAGSGFGFGGGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTVNQNLLTPLNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTIKQNLDPLFEQYINNLRRQLDGVMGERGRLDSELRNMQDLVEDYKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRSEIDNVKKQCANLQNAIAEAEQRGELALKDARNKLTELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTNSLSSGYGGRSNIGYGSGLGSGIGGFASDIGPLLNRRGLGSGLSVGGSGFSASSGQGGGFSSGGGSSSSVKFVSTTSSSRRSFKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSRQSSVSFRSG ---CCCCCCCEECCC	31.43	22673903
6	Phosphorylation	--MSRQSSVSFRSGG --CCCCCCCEECCCC	17.28	22673903
8	Phosphorylation	MSRQSSVSFRSGGSR CCCCCCCEECCCCCC	19.52	22673903
15	Methylation	SFRSGGSRSFSAASA EECCCCCCCCCCHHH	45.02	26494595
16	Phosphorylation	FRSGGSRSFSAASAI ECCCCCCCCCCHHHC	25.83	22673903
18	Phosphorylation	SGGSRSFSAASAITP CCCCCCCCCHHHCCC	24.95	22673903
21	Phosphorylation	SRSFSAASAITPSVS CCCCCCHHHCCCCCC	21.66	22673903
26	Phosphorylation	AASAITPSVSRTTFS CHHHCCCCCCEEEEE	24.87	-
31	Phosphorylation	TPSVSRTTFSSVSRS CCCCCEEEEEECCCC	22.02	26022182
33	Phosphorylation	SVSRTTFSSVSRSGG CCCEEEEEECCCCCC	27.95	18779572
34	Phosphorylation	VSRTTFSSVSRSGGG CCEEEEEECCCCCCC	21.66	22673903
36	Phosphorylation	RTTFSSVSRSGGGGG EEEEEECCCCCCCCC	23.76	18779572
37	Methylation	TTFSSVSRSGGGGGR EEEEECCCCCCCCCC	36.85	26494601
46	Phosphorylation	GGGGGRVSLGGAYGA CCCCCCEECCCCCCC	21.67	-
59	Methylation	GAGGYGSRSLYNVGG CCCCCCCCEEEECCC	26.73	26494607
60	Phosphorylation	AGGYGSRSLYNVGGS CCCCCCCEEEECCCC	36.58	22673903
67	Phosphorylation	SLYNVGGSKRISFSS EEEECCCCCEEEECC	16.90	22673903
71	Phosphorylation	VGGSKRISFSSGGGS CCCCCEEEECCCCCC	24.10	22673903
73	Phosphorylation	GSKRISFSSGGGSFR CCCEEEECCCCCCCC	22.68	23984901
74	Phosphorylation	SKRISFSSGGGSFRN CCEEEECCCCCCCCC	39.17	22673903
78	Phosphorylation	SFSSGGGSFRNQFGA EECCCCCCCCCCCCC	25.06	22673903
170	Phosphorylation	EEREQIKTLNNKFAS HHHHHHHHHHHHHHH	36.03	23984901
174	Acetylation	QIKTLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	25475321
177	Phosphorylation	TLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	22673903
181	Acetylation	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	25475323
195	Acetylation	QNKVLDTKWTLLQEQ HHCHHHHHHHHHHHH	37.54	22902405
208	Acetylation	EQGTKTIKQNLDPLF HHCCHHHHHHCHHHH	38.06	22902405
238	Phosphorylation	GERGRLDSELRNMQD CCCCHHHHHHHHHHH	43.02	22673903
253	Acetylation	LVEDYKNKYEDEINK HHHHHHHHHHHHHHH	45.95	55169327
282	Acetylation	VDAAYMNKVELEAKV CCHHHHCCHHHHHHH	22.13	22902405
328	Phosphorylation	LSMDNNRSLDLDSII EECCCCCCCCHHHHH	28.49	22673903
333	Phosphorylation	NRSLDLDSIIAEVKA CCCCCHHHHHHHHHH	24.16	22673903
379	Acetylation	GDDLRNTKHEISEMN CHHHHHHHHHHHHHH	42.67	22902405
422	Acetylation	QRGELALKDARNKLT HHHHHHHHHHHHHHH	43.67	22902405
427	Acetylation	ALKDARNKLTELEEA HHHHHHHHHHHHHHH	51.76	22902405
437	Acetylation	ELEEALQKAKQDMAR HHHHHHHHHHHHHHH	59.40	22902405
506	Phosphorylation	GGRSNIGYGSGLGSG CCCCCCCCCCCCCCC	12.34	22673903
508	Phosphorylation	RSNIGYGSGLGSGIG CCCCCCCCCCCCCCC	23.51	22673903
512	Phosphorylation	GYGSGLGSGIGGFAS CCCCCCCCCCCCCHH	32.07	22673903
527	Methylation	DIGPLLNRRGLGSGL HHHHHHHCCCCCCCC	33.73	-
535	Phosphorylation	RGLGSGLSVGGSGFS CCCCCCCEECCCCCC	23.42	22673903
539	Phosphorylation	SGLSVGGSGFSASSG CCCEECCCCCCCCCC	30.64	22673903
542	Phosphorylation	SVGGSGFSASSGQGG EECCCCCCCCCCCCC	30.66	22673903
544	Phosphorylation	GGSGFSASSGQGGGF CCCCCCCCCCCCCCC	33.53	22673903
545	Phosphorylation	GSGFSASSGQGGGFS CCCCCCCCCCCCCCC	34.55	22673903
552	Phosphorylation	SGQGGGFSSGGGSSS CCCCCCCCCCCCCCC	31.20	22673903
553	Phosphorylation	GQGGGFSSGGGSSSS CCCCCCCCCCCCCCC	38.91	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C5_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2C5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C5_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of K2C5_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.