K1C10_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K1C10_RAT
• UniProt AC: Q6IFW6
• Protein Name: Keratin, type I cytoskeletal 10
• Gene Name: Krt10 {ECO:0000250|UniProtKB:P13645}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 526
• Protein Description: Plays a role in the establishment of the epidermal barrier on plantar skin..
• Protein Sequence: MSVRFSSNSRQYSSARSGGGGGGGGGGSSIRVSSTKSSLGGGYSSGGFSGGSFSRGSSSGGCFGGSSGGYGGFGGGSFGGGYGGGSFGGGYGGGSFGGGYGGGSFGGGYGGGSFGGGSFGGGSFGGGSFGGGLGGDGGGLLSGNEKVTMQNLNDRLASYMNKVRDLEESNYELEGKIKEWYEKHGNSSQREPRDYSKYYKTIEDLKGQIVNLTTDNANVLLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLDELTLSKADLEMQIESLTEELAYLKKNHEEEMKDLQNVSTGDVNVEMNAAPGVDLTQLLNNMRNQYEQLAEKNRKDAEAWFNEKSKELTTEIDSNIEQMSSHKSEITELRRTVQGLEIELQSQLALKQSLEASLAETEGRYCVQLSQIQSQISALEEQLQQIRAETECQNAEYQQLLDIKTRLENEIQTYRSLLEGEGGYVGNLQITLNCFPSEFHLAKLTQTQGKTRGWKGSNTNKTRVIKTIIEEVTPEGRVLSSMIESETKKHFY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	RQYSSARSGGGGGGG CCCCCCCCCCCCCCC	41.32	-
38	Phosphorylation	RVSSTKSSLGGGYSS EECCCCCCCCCCCCC	32.37	-
44	Phosphorylation	SSLGGGYSSGGFSGG CCCCCCCCCCCCCCC	26.28	23984901
45	Phosphorylation	SLGGGYSSGGFSGGS CCCCCCCCCCCCCCC	34.16	23984901
49	Phosphorylation	GYSSGGFSGGSFSRG CCCCCCCCCCCCCCC	45.58	23984901
52	Phosphorylation	SGGFSGGSFSRGSSS CCCCCCCCCCCCCCC	24.47	23984901
54	Phosphorylation	GFSGGSFSRGSSSGG CCCCCCCCCCCCCCC	37.11	23984901
162	Acetylation	RLASYMNKVRDLEES HHHHHHHHHHHHHHC	23.32	22902405
169	Phosphorylation	KVRDLEESNYELEGK HHHHHHHCCCCCHHH	35.02	-
176	Acetylation	SNYELEGKIKEWYEK CCCCCHHHHHHHHHH	41.03	22902405
178	Acetylation	YELEGKIKEWYEKHG CCCHHHHHHHHHHHC	45.76	22902405
183	Acetylation	KIKEWYEKHGNSSQR HHHHHHHHHCCCCCC	40.91	22902405
197	Acetylation	REPRDYSKYYKTIED CCCCHHHHHHHHHHH	46.50	22902405
200	Acetylation	RDYSKYYKTIEDLKG CHHHHHHHHHHHHCC	39.68	22902405
236	Acetylation	AADDFRLKYENEVAL CCCHHHHHHHCHHHH	46.38	22902405
281	Phosphorylation	SLTEELAYLKKNHEE HHHHHHHHHHHCCHH	31.51	29779826
298	Phosphorylation	KDLQNVSTGDVNVEM HHHCCCCCCCCCCCC	32.87	26022182
314	Phosphorylation	AAPGVDLTQLLNNMR CCCCCCHHHHHHHHH	16.83	26022182
330	Acetylation	QYEQLAEKNRKDAEA HHHHHHHHHHHHHHH	57.34	22902405
333	Acetylation	QLAEKNRKDAEAWFN HHHHHHHHHHHHHHH	71.35	22902405
342	Acetylation	AEAWFNEKSKELTTE HHHHHHHHHHHHHHH	68.85	22902405
361	Acetylation	IEQMSSHKSEITELR HHHHHHCHHHHHHHH	52.29	22902405
438	Acetylation	YQQLLDIKTRLENEI HHHHHHHHHHHHHHH	27.53	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K1C10_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K1C10_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K1C10_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of K1C10_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.