COPD_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPD_RAT
• UniProt AC: Q66H80
• Protein Name: Coatomer subunit delta
• Gene Name: Arcn1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 511
• Subcellular Localization: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side o
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)..
• Protein Sequence: MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPMEKLYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALGYRENVNLAQIRTFTEMDSHEEKVFRAVRETQEREAKAEMRRKAKELQQARRDAERQGKKAPGFGGFGSSAVSGGSTAAMITETIIETDKPKVAPAPARPSGPSKALKLGAKGKEVDNFVDKLKSEGETIMSSNMGKRTSEAAKVHAPPINMESVHMKIEEKITLTCGRDGGLQNMELHGMIMLRISDDKFGRIRLHVENEDKKGVQLQTHPNVDKKLFTAESLIGLKNPEKSFPVNSDVGVLKWRLQTTEESFIPLTINCWPSESGNGCDVNIEYELQEDNLELNDVVITIPLPSGVGAPVIGEIDGEYRHDSRRNTLEWCLPVIDAKNKSGSLEFSIPGQPNDFFPVQVSFISKKNYCNIQVTKVTQVDGNSPVRFSTETTFLVDKYEIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
134	Phosphorylation	LAQIRTFTEMDSHEE HHHEEEEECCCCHHH	29.77	25575281
138	Phosphorylation	RTFTEMDSHEEKVFR EEEECCCCHHHHHHH	31.33	25575281
178	Ubiquitination	RDAERQGKKAPGFGG HHHHHCCCCCCCCCC	37.11	-
179	Ubiquitination	DAERQGKKAPGFGGF HHHHCCCCCCCCCCC	67.64	-
188	Phosphorylation	PGFGGFGSSAVSGGS CCCCCCCCCCCCCCC	16.92	23984901
189	Phosphorylation	GFGGFGSSAVSGGST CCCCCCCCCCCCCCH	32.82	23984901
192	Phosphorylation	GFGSSAVSGGSTAAM CCCCCCCCCCCHHEE	36.83	28432305
195	Phosphorylation	SSAVSGGSTAAMITE CCCCCCCCHHEEEEE	20.56	23984901
196	Phosphorylation	SAVSGGSTAAMITET CCCCCCCHHEEEEEE	23.01	28432305
201	Phosphorylation	GSTAAMITETIIETD CCHHEEEEEEHHHCC	17.62	30181290
203	Phosphorylation	TAAMITETIIETDKP HHEEEEEEHHHCCCC	20.71	30181290
223	Phosphorylation	PARPSGPSKALKLGA CCCCCCCCCCCCCCC	33.80	-
227	Acetylation	SGPSKALKLGAKGKE CCCCCCCCCCCCCCC	50.13	-
233	Acetylation	LKLGAKGKEVDNFVD CCCCCCCCCCHHHHH	54.58	22902405
241	Acetylation	EVDNFVDKLKSEGET CCHHHHHHHHHHCCC	53.14	-
244	Phosphorylation	NFVDKLKSEGETIMS HHHHHHHHHCCCHHH	62.36	-
309	Acetylation	MLRISDDKFGRIRLH EEEECCCCCCEEEEE	55.50	22902405
342	Phosphorylation	KKLFTAESLIGLKNP HHCEEHHHHHCCCCC	23.87	23984901
347	Acetylation	AESLIGLKNPEKSFP HHHHHCCCCCCCCCC	66.30	22902405
351	Acetylation	IGLKNPEKSFPVNSD HCCCCCCCCCCCCCC	59.67	22902405
437	Phosphorylation	RHDSRRNTLEWCLPV CCCCCCCCEEEEEEE	25.01	23984901
493	Phosphorylation	VTQVDGNSPVRFSTE EEEECCCCCEEEEEE	30.24	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPD_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPD_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPD_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of COPD_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.