ANXA2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANXA2_RAT
• UniProt AC: Q07936
• Protein Name: Annexin A2
• Gene Name: Anxa2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 339
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane . Melanosome. In the lamina beneath the plasma membrane.
• Protein Description: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9..
• Protein Sequence: MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPSAMKSALSGHLETVMLGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGEFRKLLVALAKGKRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYFIQQDTKGDYQKALLYLCGGDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTVHEILC ------CCCHHHHHH	38.85	23984901
2	Acetylation	------MSTVHEILC ------CCCHHHHHH	38.85	-
3	Phosphorylation	-----MSTVHEILCK -----CCCHHHHHHH	25.28	23984901
12	Phosphorylation	HEILCKLSLEGDHST HHHHHHHHCCCCCCC	15.18	24317
18	Phosphorylation	LSLEGDHSTPPSAYG HHCCCCCCCCCHHCC	47.55	23984901
19	Phosphorylation	SLEGDHSTPPSAYGS HCCCCCCCCCHHCCC	35.48	23984901
22	Phosphorylation	GDHSTPPSAYGSVKP CCCCCCCHHCCCCCC	35.01	25532521
24	Phosphorylation	HSTPPSAYGSVKPYT CCCCCHHCCCCCCCC	17.80	25532521
26	Phosphorylation	TPPSAYGSVKPYTNF CCCHHCCCCCCCCCC	17.81	30181290
28	Acetylation	PSAYGSVKPYTNFDA CHHCCCCCCCCCCCH	33.72	22902405
49	Acetylation	IETAIKTKGVDEVTI HHHHHHCCCCCEEEE	52.51	22902405
55	Phosphorylation	TKGVDEVTIVNILTN CCCCCEEEEEEEECC	19.70	23984901
89	Phosphorylation	ELPSAMKSALSGHLE HCCHHHHHHHHHCHH	22.74	34801875
92	Phosphorylation	SAMKSALSGHLETVM HHHHHHHHHCHHHHH	24.71	23984901
104	Acetylation	TVMLGLLKTPAQYDA HHHHHHHCCHHHCCH	58.46	22902405
115	Acetylation	QYDASELKASMKGLG HCCHHHHHHHHCCCC	34.07	22902405
117	Phosphorylation	DASELKASMKGLGTD CHHHHHHHHCCCCCC	21.31	23984901
119	Acetylation	SELKASMKGLGTDED HHHHHHHCCCCCCHH	48.79	22902405
123	Phosphorylation	ASMKGLGTDEDSLIE HHHCCCCCCHHHHHH	41.06	23984901
127	Phosphorylation	GLGTDEDSLIEIICS CCCCCHHHHHHHHHH	29.24	23984901
148	Acetylation	QEINRVYKEMYKTDL HHHHHHHHHHHCCHH	32.90	22902405
152	Acetylation	RVYKEMYKTDLEKDI HHHHHHHCCHHHHHH	33.96	22902405
157	Acetylation	MYKTDLEKDIISDTS HHCCHHHHHHHCCCC	62.62	22902405
169	Acetylation	DTSGEFRKLLVALAK CCCHHHHHHHHHHHC	52.04	26302492
184	Phosphorylation	GKRAEDGSVIDYELI CCCCCCCCCCCCEEC	28.37	28109543
188	Phosphorylation	EDGSVIDYELIDQDA CCCCCCCCEECCHHH	11.08	23984901
199	Phosphorylation	DQDARELYDAGVKRK CHHHHHHHHHCCCCC	10.05	-
212	Acetylation	RKGTDVPKWISIMTE CCCCCCCHHHHHHHH	57.94	22902405
227	Acetylation	RSVCHLQKVFERYKS HHHHHHHHHHHHHHC	56.08	25786129
234	Phosphorylation	KVFERYKSYSPYDML HHHHHHHCCCHHHHH	23.16	23984901
235	Phosphorylation	VFERYKSYSPYDMLE HHHHHHCCCHHHHHH	14.98	23984901
236	Phosphorylation	FERYKSYSPYDMLES HHHHHCCCHHHHHHH	24.87	23984901
238	Phosphorylation	RYKSYSPYDMLESIR HHHCCCHHHHHHHHH	14.19	-
279	Acetylation	DRLYDSMKGKGTRDK HHHHHHHCCCCCCCH	62.51	22902405
286	Acetylation	KGKGTRDKVLIRIMV CCCCCCCHHHEEEEE	35.33	22902405
302	Acetylation	RSEVDMLKIRSEFKR HHHHCHHHHHHHHHH	29.45	22902405
308	Acetylation	LKIRSEFKRKYGKSL HHHHHHHHHHHCCCC	43.88	22902405
313	Acetylation	EFKRKYGKSLYYFIQ HHHHHHCCCCEEEHH	33.91	22902405
314	Phosphorylation	FKRKYGKSLYYFIQQ HHHHHCCCCEEEHHC	19.76	23984901
324	Acetylation	YFIQQDTKGDYQKAL EEHHCCCCCCHHHHH	59.06	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
24	Y	Phosphorylation	Kinase	SRC	Q9WUD9	Uniprot
26	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANXA2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANXA2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ANXA2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.