SYWC_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYWC_RAT
• UniProt AC: Q6P7B0
• Protein Name: Tryptophan--tRNA ligase, cytoplasmic
• Gene Name: Wars
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 481
• Subcellular Localization: Cytoplasm.
• Protein Description: T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity)..
• Protein Sequence: MADMPSGESCTSPLELFNSIAAQGELVRSLKAGNAPKDEIESAVKMLLSLKMNYKTAMGEEYKAGCPPGNSTAGSNGDPDATKASEDFVDPWTVRTSSAKGIDYDKLIVQFGSSKIDKELINRIERATGQRPHRFLRRGIFFSHRDMNQILDAYENKKPFYLYTGRGPSSEAMHLGHLVPFIFTKWLQDVFDVPLVIQMSDDEKYLWKDLTLEQAYSYTVENAKDIIACGFDVNKTFIFSDLEYMGQSPGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAVQAAPSFSNSFPKIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGHPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKSKVNKHAFSGGRDTVEEHRQFGGNCEVDVSFMYLTFFLEDDDSLEQIRKDYTSGAMLTGELKKTLIDVLQPLIAEHQARRKAVTEETVKEFMAPRQLSFHFQCFCFDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Phosphorylation	AGCPPGNSTAGSNGD CCCCCCCCCCCCCCC	26.08	30181290
72	Phosphorylation	GCPPGNSTAGSNGDP CCCCCCCCCCCCCCC	38.75	30181290
75	Phosphorylation	PGNSTAGSNGDPDAT CCCCCCCCCCCCCCH	34.86	22108457
158	Succinylation	LDAYENKKPFYLYTG HHHHHCCCCEEEEEC	52.52	-
158	Succinylation	LDAYENKKPFYLYTG HHHHHCCCCEEEEEC	52.52	-
355	Phosphorylation	QGAQTKMSASDPNSS CCCCCCCCCCCCCCC	26.61	25575281
357	Phosphorylation	AQTKMSASDPNSSIF CCCCCCCCCCCCCEE	46.42	25575281
370	Acetylation	IFLTDTAKQIKSKVN EEEECHHHHHHHHHH	55.43	22902405
454	Ubiquitination	AEHQARRKAVTEETV HHHHHHHHCCCHHHH	41.47	-
462	Acetylation	AVTEETVKEFMAPRQ CCCHHHHHHHHCCCC	53.29	22902405
471	Phosphorylation	FMAPRQLSFHFQCFC HHCCCCEEEEEEEEE	14.34	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYWC_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYWC_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYWC_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SYWC_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.