UBC9_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBC9_RAT
• UniProt AC: P63281
• Protein Name: SUMO-conjugating enzyme UBC9
• Gene Name: Ube2i
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 158
• Subcellular Localization: Nucleus . Cytoplasm . Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity)..
• Protein Description: Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5. Sumoylates p53/TP53 at 'Lys-386' (By similarity)..
• Protein Sequence: MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGIALSRL ------CCCHHHHHH	38.62	-
65	Acetylation	FKLRMLFKDDYPSSP EEEEECCCCCCCCCC	45.81	22902405
70	Phosphorylation	LFKDDYPSSPPKCKF CCCCCCCCCCCCCCC	49.61	28432305
71	Phosphorylation	FKDDYPSSPPKCKFE CCCCCCCCCCCCCCC	40.49	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
71	S	Phosphorylation	Kinase	CDK1	P39951	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
71	S	Phosphorylation	Phosphorylation at Ser-71 significantly enhances SUMOylation activity.	-
71	S	Sumoylation	Phosphorylation at Ser-71 significantly enhances SUMOylation activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBC9_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GCR_RAT	Nr3c1	physical	11812797

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.