RL3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL3_RAT
• UniProt AC: P21531
• Protein Name: 60S ribosomal protein L3
• Gene Name: Rpl3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 403
• Subcellular Localization: Nucleus, nucleolus. Cytoplasm.
• Protein Description: The L3 protein is a component of the large subunit of cytoplasmic ribosomes..
• Protein Sequence: MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDDTGKKQLEKDFNSMKKYCQVIRIIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKNNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLKGCVVGTKKRVLTLRKSLLVQTKRRALEKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSHRKFSAPRHGSL -CCCCCCCCCCCCCC	40.16	23984901
13	Phosphorylation	FSAPRHGSLGFLPRK CCCCCCCCCCCCCCC	21.13	27097102
39	Acetylation	FPKDDPSKPVHLTAF CCCCCCCCCCEEEEE	57.35	22902405
136	Acetylation	AFTKYCKKWQDDTGK HHHHHHHHHCCCHHH	46.67	-
154	Acetylation	EKDFNSMKKYCQVIR HHHHHHHHHHHHHHH	40.17	22902405
155	Succinylation	KDFNSMKKYCQVIRI HHHHHHHHHHHHHHH	42.49	26843850
189	Phosphorylation	EIQVNGGTVAEKLDW EEEECCCHHHHHHHH	20.24	23984901
286	Ubiquitination	EINKKIYKIGQGYLI HHHHHHEEECCCEEE	43.78	-
286	Acetylation	EINKKIYKIGQGYLI HHHHHHEEECCCEEE	43.78	-
294	Acetylation	IGQGYLIKDGKLIKN ECCCEEEECCCEECC	58.81	22902405
300	Ubiquitination	IKDGKLIKNNASTDY EECCCEECCCCCCCC	55.36	-
304	Phosphorylation	KLIKNNASTDYDLSD CEECCCCCCCCCCCC	24.76	23984901
305	Phosphorylation	LIKNNASTDYDLSDK EECCCCCCCCCCCCC	35.85	23984901
307	Phosphorylation	KNNASTDYDLSDKSI CCCCCCCCCCCCCCC	20.90	23984901
310	Phosphorylation	ASTDYDLSDKSINPL CCCCCCCCCCCCCCC	39.84	23984901
313	Phosphorylation	DYDLSDKSINPLGGF CCCCCCCCCCCCCCC	32.37	23984901
356	Acetylation	KSLLVQTKRRALEKI HHHHHHHHHHHHHHC	23.85	72612797
362	Acetylation	TKRRALEKIDLKFID HHHHHHHHCCEEEEE	42.23	72611429
366	Acetylation	ALEKIDLKFIDTTSK HHHHCCEEEEECCCC	36.20	22902405
373	Acetylation	KFIDTTSKFGHGRFQ EEEECCCCCCCCCCC	53.96	22902405
385	Acetylation	RFQTMEEKKAFMGPL CCCCHHHHHHHCCCC	35.77	22902405
399	Acetylation	LKKDRIAKEEGA--- CHHHHHHHHCCC---	54.66	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RL3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.