SOX10_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOX10_RAT
• UniProt AC: O55170
• Protein Name: Transcription factor SOX-10
• Gene Name: Sox10
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 466
• Subcellular Localization: Cytoplasm . Nucleus . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity)..
• Protein Sequence: MAEEQDLSEVELSPVGSEEPRCLSPSSAPSLGPDGGGGGSGLRASPGPGELGKVKKEQQDGEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQGEAECPGGETDQGGAAAIQAHYKSAHLDHRHPEEGSPMSDGNPEHPSGQSHGPPTPPTTPKTELQSGKADPKRDGRSLGEGGKPHIDFGNVDIGEISHEVMSNMETFDVTELDQYLPPNGHPGHVGSYSAAGYGLSSALAVASGHSAWISKPPGVALPTVSPPAVDAKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHAGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPTHWEQPVYTTLSRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	SEEPRCLSPSSAPSL CCCCCCCCCCCCCCC	26.76	27097102
26	Phosphorylation	EPRCLSPSSAPSLGP CCCCCCCCCCCCCCC	35.44	27097102
27	Phosphorylation	PRCLSPSSAPSLGPD CCCCCCCCCCCCCCC	47.81	27097102
30	Phosphorylation	LSPSSAPSLGPDGGG CCCCCCCCCCCCCCC	45.75	27097102
40	Phosphorylation	PDGGGGGSGLRASPG CCCCCCCCCCCCCCC	37.62	27097102
45	Phosphorylation	GGSGLRASPGPGELG CCCCCCCCCCCCCCC	24.77	27097102
140	Acetylation	ELSKTLGKLWRLLNE HHHHHHHHHHHHHCC	48.25	72536005
221	Phosphorylation	HRHPEEGSPMSDGNP CCCCCCCCCCCCCCC	22.25	27097102
224	Phosphorylation	PEEGSPMSDGNPEHP CCCCCCCCCCCCCCC	45.83	27097102
232	Phosphorylation	DGNPEHPSGQSHGPP CCCCCCCCCCCCCCC	51.91	27097102
235	Phosphorylation	PEHPSGQSHGPPTPP CCCCCCCCCCCCCCC	33.66	27097102
240	Phosphorylation	GQSHGPPTPPTTPKT CCCCCCCCCCCCCCH	45.06	27097102
243	Phosphorylation	HGPPTPPTTPKTELQ CCCCCCCCCCCHHHC	57.86	27097102
244	Phosphorylation	GPPTPPTTPKTELQS CCCCCCCCCCHHHCC	28.67	27097102
440	Phosphorylation	RPLYTAISDPSPSGP CCCEEECCCCCCCCC	40.79	27097102
443	Phosphorylation	YTAISDPSPSGPQSH EEECCCCCCCCCCCC	36.37	27097102
445	Phosphorylation	AISDPSPSGPQSHSP ECCCCCCCCCCCCCC	68.40	27097102
449	Phosphorylation	PSPSGPQSHSPTHWE CCCCCCCCCCCCCCC	29.12	27097102
451	Phosphorylation	PSGPQSHSPTHWEQP CCCCCCCCCCCCCCC	36.42	27097102
453	Phosphorylation	GPQSHSPTHWEQPVY CCCCCCCCCCCCCCE	42.51	27097102
460	Phosphorylation	THWEQPVYTTLSRP- CCCCCCCEEECCCC-	10.74	27097102
461	Phosphorylation	HWEQPVYTTLSRP-- CCCCCCEEECCCC--	22.84	27097102
462	Phosphorylation	WEQPVYTTLSRP--- CCCCCEEECCCC---	12.68	27097102
464	Phosphorylation	QPVYTTLSRP----- CCCEEECCCC-----	40.18	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOX10_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOX10_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOX10_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAX6_MOUSE	Pax6	physical	16582099
MEOX1_MOUSE	Meox1	physical	16582099
DLX5_MOUSE	Dlx5	physical	16582099
HHEX_MOUSE	Hhex	physical	16582099
ALX4_MOUSE	Alx4	physical	16582099
HXA3_MOUSE	Hoxa3	physical	16582099
PO3F3_MOUSE	Pou3f3	physical	16582099
UTF1_MOUSE	Utf1	physical	16582099
HTF4_MOUSE	Tcf12	physical	16582099
OLIG2_MOUSE	Olig2	physical	16582099
JUN_MOUSE	Jun	physical	16582099
CEBPA_MOUSE	Cebpa	physical	16582099
EGR2_MOUSE	Egr2	physical	16582099
SP1_MOUSE	Sp1	physical	16582099
PAX3_MOUSE	Pax3	physical	16582099

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.