PAX6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAX6_MOUSE
• UniProt AC: P63015
• Protein Name: Paired box protein Pax-6
• Gene Name: Pax6
• Organism: Mus musculus (Mouse).
• Sequence Length: 422
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity)..
• Protein Sequence: MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63 (in isoform 2)	Phosphorylation	-	21.80	21149613
68 (in isoform 2)	Phosphorylation	-	28.52	21149613
91	Sumoylation	VSKIAQYKRECPSIF HHHHHHHHHHCCCHH	29.64	-
108	Phosphorylation	EIRDRLLSEGVCTND HHHHHHHHCCCCCCC	36.58	21454597
113	Phosphorylation	LLSEGVCTNDNIPSV HHHCCCCCCCCCCCH	43.11	21454597
230	Phosphorylation	EALEKEFERTHYPDV HHHHHHHHHHCCCCH	58.73	24719451
281	Phosphorylation	QRRQASNTPSHIPIS HHHHHHCCCCCCCCC	24.55	16407227
304	Phosphorylation	QPIPQPTTPVSSFTS CCCCCCCCCCHHCCC	28.51	16407227
307	Phosphorylation	PQPTTPVSSFTSGSM CCCCCCCHHCCCCCC	22.42	-
373	Phosphorylation	GRSYDTYTPPHMQTH CCCCCCCCCCCCCCC	32.22	16407227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
281	T	Phosphorylation	Kinase	HIPK2	Q9H2X6	PSP
281	T	Phosphorylation	Kinase	HIPK2	Q9QZR5	PhosphoELM
304	T	Phosphorylation	Kinase	HIPK2	Q9H2X6	PSP
304	T	Phosphorylation	Kinase	HIPK2	Q9QZR5	PhosphoELM
373	T	Phosphorylation	Kinase	HIPK2	Q9H2X6	PSP
373	T	Phosphorylation	Kinase	HIPK2	Q9QZR5	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	Trim11	Q99PQ2	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
91	K	Sumoylation	[Isoform 3]: Sumoylated by SUMO1 at 'Lys-91'.	21084637

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAX6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOX2_MOUSE	Sox2	physical	20211142
VAX2_MOUSE	Vax2	physical	20211142
HDA10_MOUSE	Hdac10	physical	20211142
PAX6_HUMAN	PAX6	physical	16098226
HOME3_HUMAN	HOMER3	physical	16098226
TRI11_HUMAN	TRIM11	physical	16098226
DYL1_HUMAN	DYNLL1	physical	16098226
MAF_MOUSE	Maf	physical	17901057
MAFB_MOUSE	Mafb	physical	17901057
TRI11_MOUSE	Trim11	physical	18628401

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.