MAF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAF_MOUSE
• UniProt AC: P54843
• Protein Name: Transcription factor Maf
• Gene Name: Maf
• Organism: Mus musculus (Mouse).
• Sequence Length: 370
• Subcellular Localization: Nucleus.
• Protein Description: Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity). Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding..
• Protein Sequence: MASELAMNNSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIISQCGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKAHLEDYYWMTGYPQQLNPEALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPAAAVVSAVIAAAAAQSGAAPHYHHHHHHAAGHHHHPTAGAPGAAGGASASASGAGGAGGGGPASAGGGGGGGGGGGTAGAGGALHPHHAAGGLHFDDRFSDEQLVTMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRLVRERDAYKEKYEKLVSNGFRENGSSSDNPSSPEFFM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	NNSDLPTSPLAMEYV CCCCCCCCHHHHHHC	18.90	25338131
21	Phosphorylation	TSPLAMEYVNDFDLM CCHHHHHHCCHHHCC	7.46	-
33	Sumoylation	DLMKFEVKKEPVETD HCCCEEECCCCCCHH	44.19	-
33	Sumoylation	DLMKFEVKKEPVETD HCCCEEECCCCCCHH	44.19	-
92	Phosphorylation	KAHLEDYYWMTGYPQ HHHHHHHHHHCCCCC	10.88	-
131	Phosphorylation	LQGGFDGYARGAQQL HCCCCCHHHHHHHHH	8.58	-
301	Phosphorylation	KNRGYAQSCRFKRVQ HHCCHHHHHHHHHHH	10.09	20208071
360	Phosphorylation	FRENGSSSDNPSSPE CCCCCCCCCCCCCCC	43.00	20531401
364	Phosphorylation	GSSSDNPSSPEFFM- CCCCCCCCCCCCCC-	65.85	20531401
365	Phosphorylation	SSSDNPSSPEFFM-- CCCCCCCCCCCCC--	29.70	20531401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
21	Y	Phosphorylation	Kinase	TEC	P24604	PSP
92	Y	Phosphorylation	Kinase	TEC	P24604	PSP
131	Y	Phosphorylation	Kinase	TEC	P24604	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAF_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NF2L2_MOUSE	Nfe2l2	physical	16785233

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.