dbPTM

ALX4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ALX4_MOUSE
UniProt AC	O35137
Protein Name	Homeobox protein aristaless-like 4
Gene Name	Alx4
Organism	Mus musculus (Mouse).
Sequence Length	399
Subcellular Localization	Nucleus.
Protein Description	Transcription factor involved in skull and limb development..
Protein Sequence	MNAETCVSYCESPAAAMDAYYSPVSQSREGSSPFRGFPGGDKFGTTFLSAGAKGQGFGDAKSRARYGAGQQDLAAPLESSSGARGSFNKFQPQPPTPQPPPAPPAPPAHLYLQRGACKTPPDGSLKLQEGSGGHNAALQVPCYAKESNLGEPELPPDSEPVGMDNSYLSVKETGAKGPQDRASAEIPSPLEKTDSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWIGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASSVSDFLSVSGAGSHVGQTHMGSLFGAAGISPGLNGYEMNGEPDRKTSSIAALRMKAKEHSAAISWAT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
119	Phosphorylation	LQRGACKTPPDGSLK ECCCCCCCCCCCCEE	39.68	101545919
188	Phosphorylation	RASAEIPSPLEKTDS CCCCCCCCCCCCCCC	48.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ALX4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ALX4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ALX4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ALX4_MOUSE	Alx4	physical	20211142
CDX1_MOUSE	Cdx1	physical	20211142
CDX2_MOUSE	Cdx2	physical	20211142
CDX4_MOUSE	Cdx4	physical	20211142
DLX1_MOUSE	Dlx1	physical	20211142
DLX2_MOUSE	Dlx2	physical	20211142
DLX5_MOUSE	Dlx5	physical	20211142
FOXH1_MOUSE	Foxh1	physical	20211142
FOXA1_MOUSE	Foxa1	physical	20211142
HXA10_MOUSE	Hoxa10	physical	20211142
HXA11_MOUSE	Hoxa11	physical	20211142
HXB13_MOUSE	Hoxb13	physical	20211142
HXC4_MOUSE	Hoxc4	physical	20211142
HXD12_MOUSE	Hoxd12	physical	20211142
HXD13_MOUSE	Hoxd13	physical	20211142
LDB1_MOUSE	Ldb1	physical	20211142
LMX1B_MOUSE	Lmx1b	physical	20211142
PAX3_MOUSE	Pax3	physical	20211142
PRRX1_MOUSE	Prrx1	physical	20211142
PO3F4_MOUSE	Pou3f4	physical	20211142
PO4F2_MOUSE	Pou4f2	physical	20211142
RX_MOUSE	Rax	physical	20211142
SOX15_MOUSE	Sox15	physical	20211142
SOX2_MOUSE	Sox2	physical	20211142
MIXL1_MOUSE	Mixl1	physical	20211142
TBX21_MOUSE	Tbx21	physical	20211142
ERCC8_MOUSE	Ercc8	physical	20211142
TLE6_MOUSE	Tle6	physical	20211142
MED16_MOUSE	Med16	physical	20211142
TF3C1_MOUSE	Gtf3c1	physical	20211142

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ALX4_MOUSE

Related Literatures of Post-Translational Modification