dbPTM

HXD13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HXD13_MOUSE
UniProt AC	P70217
Protein Name	Homeobox protein Hox-D13
Gene Name	Hoxd13
Organism	Mus musculus (Mouse).
Sequence Length	339
Subcellular Localization	Nucleus .
Protein Description	Sequence-specific transcription factor that binds gene promoters and activates their transcription. [PubMed: 23995701 Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity]
Protein Sequence	MSRSGTWDMDGLRADGGAAGAAPASSSSSVAAPGQCRGFLSAPVFAGTHSGRAAAAAAAAAAAAAAASSFAYPGTSERTGSSSSSSSSAVIATRPEAPVAKECPAPAAAATAAAPPGAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPTNEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNSQVYCAKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Phosphorylation	AAAAAAASSFAYPGT HHHHHHHHHHCCCCC	22.66	28285833
76	Phosphorylation	SFAYPGTSERTGSSS HHCCCCCCCCCCCCC	30.88	28285833
162	Acetylation	LGGFPVEKYMDVSGL HCCCCCHHEEECCCC	46.22	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HXD13_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HXD13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HXD13_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOX15_MOUSE	Sox15	physical	20211142
HAND2_MOUSE	Hand2	physical	20386744
SMAD5_MOUSE	Smad5	physical	16087734
MEIS1_MOUSE	Meis1	physical	16087734
SMAD1_MOUSE	Smad1	physical	16087734
SMAD2_MOUSE	Smad2	physical	16087734

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HXD13_MOUSE

Related Literatures of Post-Translational Modification