HAND2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HAND2_MOUSE
• UniProt AC: Q61039
• Protein Name: Heart- and neural crest derivatives-expressed protein 2
• Gene Name: Hand2
• Organism: Mus musculus (Mouse).
• Sequence Length: 217
• Subcellular Localization: Nucleus .
• Protein Description: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'..
• Protein Sequence: MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVWALELKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	Phosphorylation	NRKERRRTQSINSAF CHHHHHHHHHHHHHH	25.51	28066266
114	Phosphorylation	KERRRTQSINSAFAE HHHHHHHHHHHHHHH	24.11	28066266
183	Ubiquitination	VKEEKRKKELNEILK CCHHHHHHHHHHHHH	72.04	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HAND2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HAND2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HAND2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFE2_MOUSE	Tcf3	physical	15351717
ITF2_MOUSE	Tcf4	physical	15351717
HTF4_MOUSE	Tcf12	physical	15351717
HAND1_MOUSE	Hand1	physical	12392994
NKX25_MOUSE	Nkx2-5	physical	12392994

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.