MEIS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEIS1_MOUSE
• UniProt AC: Q60954
• Protein Name: Homeobox protein Meis1
• Gene Name: Meis1
• Organism: Mus musculus (Mouse).
• Sequence Length: 390
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias..
• Protein Sequence: MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDVTRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	MDGVGIPSTMYGDPH CCCCCCCHHHCCCCC	24.72	-
22	Phosphorylation	DGVGIPSTMYGDPHA CCCCCCHHHCCCCCH	14.73	-
24	Phosphorylation	VGIPSTMYGDPHAAR CCCCHHHCCCCCHHH	20.61	-
32	Phosphorylation	GDPHAARSMQPVHHL CCCCHHHHCCCCCCC	19.62	25367039
47	Phosphorylation	NHGPPLHSHQYPHTA CCCCCCCCCCCCCCC	21.70	25367039
50	Phosphorylation	PPLHSHQYPHTAHTN CCCCCCCCCCCCCCC	7.49	25367039
53	Phosphorylation	HSHQYPHTAHTNAMA CCCCCCCCCCCCCCC	18.68	25367039
56	Phosphorylation	QYPHTAHTNAMAPSM CCCCCCCCCCCCCCC	23.39	25367039
62	Phosphorylation	HTNAMAPSMGSSVND CCCCCCCCCCCHHHH	26.66	25367039
65	Phosphorylation	AMAPSMGSSVNDALK CCCCCCCCHHHHHHH	23.59	25367039
66	Phosphorylation	MAPSMGSSVNDALKR CCCCCCCHHHHHHHH	21.14	25367039
194	Phosphorylation	IDDREGGSKSDSEDV EECCCCCCCCCCHHC	39.58	26824392
196	Phosphorylation	DREGGSKSDSEDVTR CCCCCCCCCCHHCHH	48.33	27087446
198	Phosphorylation	EGGSKSDSEDVTRSA CCCCCCCCHHCHHHC	42.67	23737553
202	Phosphorylation	KSDSEDVTRSANLTD CCCCHHCHHHCCCCC	31.09	27742792
220	Phosphorylation	WNRDHDDTASTRSGG CCCCCCCCCCCCCCC	28.68	25338131
225	Phosphorylation	DDTASTRSGGTPGPS CCCCCCCCCCCCCCC	41.48	25338131
228	Phosphorylation	ASTRSGGTPGPSSGG CCCCCCCCCCCCCCC	28.70	25338131
232	Phosphorylation	SGGTPGPSSGGHTSH CCCCCCCCCCCCCCC	47.75	25338131
245	Phosphorylation	SHSGDNSSEQGDGLD CCCCCCCCCCCCCCC	39.95	25338131
257	Phosphorylation	GLDNSVASPSTGDDD CCCCCCCCCCCCCCC	19.75	25338131
259	Phosphorylation	DNSVASPSTGDDDDP CCCCCCCCCCCCCCC	42.39	25338131
260	Phosphorylation	NSVASPSTGDDDDPD CCCCCCCCCCCCCCC	48.27	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEIS1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEIS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEIS1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PBX2_MOUSE	Pbx2	physical	20211142
PBX3_MOUSE	Pbx3	physical	20211142
PKNX1_MOUSE	Pknox1	physical	20211142
PBX4_MOUSE	Pbx4	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.