PBX2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PBX2_MOUSE
• UniProt AC: O35984
• Protein Name: Pre-B-cell leukemia transcription factor 2
• Gene Name: Pbx2
• Organism: Mus musculus (Mouse).
• Sequence Length: 430
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1 (By similarity)..
• Protein Sequence: MDERLLGPPPPGGGRGGLGLVGAEPGGPGEPPGGGDPGGGSGGVPGGRGKQDIGDILQQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRSSQEEEPVDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGGVSPDNSIEHSDYRSKLAQIRHIYHSELEKYEQACNEFTTHVMNLLREQSRTRPVAPKEMERMVSIIHRKFSAIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAVKTAVSVAQGGHSRTSSPTPPSSAGSGGSFNLSGSGDMFLGMPGLNGDSYPASQVESLRHSMGPGSYGDNIGGGQIYSPREIRANGGWQEAVTPSSVTSPTEGPGSVHSDTSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	Phosphorylation	RMKPALFSVLCEIKE HHCHHHHHHHHHHHH	18.28	-
104	Phosphorylation	KTGLSIRSSQEEEPV HHCCCCCCCCCCCCC	34.40	25338131
105	Phosphorylation	TGLSIRSSQEEEPVD HCCCCCCCCCCCCCC	31.59	25338131
136	Phosphorylation	GPEKGGGSAAAAAAA CCCCCCHHHHHHHHH	20.29	25619855
146	Phosphorylation	AAAAAAASGGGVSPD HHHHHHHHCCCCCCC	32.99	25619855
151	Phosphorylation	AASGGGVSPDNSIEH HHHCCCCCCCCCCCC	29.79	25521595
155	Phosphorylation	GGVSPDNSIEHSDYR CCCCCCCCCCCHHHH	36.41	25619855
159	Phosphorylation	PDNSIEHSDYRSKLA CCCCCCCHHHHHHHH	24.44	21082442
161	Phosphorylation	NSIEHSDYRSKLAQI CCCCCHHHHHHHHHH	21.57	25619855
298	Acetylation	VSNWFGNKRIRYKKN HHHHHCCCCEEEECC	49.97	30987089
323	Phosphorylation	YAVKTAVSVAQGGHS EEEEEEEHHHCCCCC	14.85	28285833
330	Phosphorylation	SVAQGGHSRTSSPTP HHHCCCCCCCCCCCC	40.29	25521595
383	Phosphorylation	RHSMGPGSYGDNIGG HHHCCCCCCCCCCCC	29.13	28285833
394	Phosphorylation	NIGGGQIYSPREIRA CCCCCCEECHHHHCC	12.53	24759943
395	Phosphorylation	IGGGQIYSPREIRAN CCCCCEECHHHHCCC	21.07	23684622
418	Phosphorylation	PSSVTSPTEGPGSVH CCCCCCCCCCCCCCC	54.03	21183079
423	Phosphorylation	SPTEGPGSVHSDTSN CCCCCCCCCCCCCCC	21.57	23684622
426	Phosphorylation	EGPGSVHSDTSN--- CCCCCCCCCCCC---	40.19	23684622
428	Phosphorylation	PGSVHSDTSN----- CCCCCCCCCC-----	32.93	23684622
429	Phosphorylation	GSVHSDTSN------ CCCCCCCCC------	45.60	23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PBX2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PBX2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PBX2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TLX3_MOUSE	Tlx3	physical	20211142
PKNX2_MOUSE	Pknox2	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330, AND MASSSPECTROMETRY.
PubMed: 19367708