PBX3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PBX3_MOUSE
• UniProt AC: O35317
• Protein Name: Pre-B-cell leukemia transcription factor 3
• Gene Name: Pbx3
• Organism: Mus musculus (Mouse).
• Sequence Length: 434
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'..
• Protein Sequence: MDDQSRMLQTLAGVNLAGHSVQGGMALPPPPHGHEGADGDGRKQDIGDILHQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAASGGSSDNSIEHSDYRAKLTQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGANSLYSPHNLNANGGWQDATTPSSVTSPTEGPGSVHSDTSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Phosphorylation	RMKPALFSVLCEIKE HHCHHHHHHHHHHHH	18.28	-
129	Phosphorylation	GPEKGGGSAAAAAAA CCCCCCHHHHHHHHH	20.29	-
195	Phosphorylation	QSRTRPISPKEIERM HHCCCCCCHHHHHHH	32.38	24719451
211	Phosphorylation	GIIHRKFSSIQMQLK HHHHHHHCHHHHHHH	29.57	30635358
212	Phosphorylation	IIHRKFSSIQMQLKQ HHHHHHCHHHHHHHH	21.70	30635358
220	Phosphorylation	IQMQLKQSTCEAVMI HHHHHHHCHHHHHHH	33.18	30635358
221	Phosphorylation	QMQLKQSTCEAVMIL HHHHHHCHHHHHHHH	16.33	30635358
299	Acetylation	RYKKNIGKFQEEANL EEECCCCHHHHHHHH	39.83	23806337
427	Phosphorylation	SPTEGPGSVHSDTSN CCCCCCCCCCCCCCC	21.57	23684622
430	Phosphorylation	EGPGSVHSDTSN--- CCCCCCCCCCCC---	40.19	23684622
432	Phosphorylation	PGSVHSDTSN----- CCCCCCCCCC-----	32.93	23684622
433	Phosphorylation	GSVHSDTSN------ CCCCCCCCC------	45.60	23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PBX3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PBX3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PBX3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PKNX1_MOUSE	Pknox1	physical	20211142
TCF21_MOUSE	Tcf21	physical	20211142
PKNX2_MOUSE	Pknox2	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.