CDX2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDX2_MOUSE
• UniProt AC: P43241
• Protein Name: Homeobox protein CDX-2
• Gene Name: Cdx2
• Organism: Mus musculus (Mouse).
• Sequence Length: 311
• Subcellular Localization: Nucleus.
• Protein Description: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA..
• Protein Sequence: MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAATANLDSAQSPGPSWPTAYGAPLREDWNGYAPGGAAAANAVAHGLNGGSPAAAMGYSSPAEYHAHHHPHHHPHHPAASPSCASGLLQTLNLGPPGPAATAAAEQLSPSGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERKIKKKQQQQQQQQQQQPPQPPPQPSQPQPGALRSVPEPLSPVTSLQGSVPGSVPGVLGPAGGVLNSTVTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MYVSYLLDKDV ----CCCEECCCCCH	7.80	26824392
60	Phosphorylation	ANLDSAQSPGPSWPT CCCCCCCCCCCCCCC	31.38	11729123
211	Phosphorylation	FHFSRYITIRRKSEL HCHHHCEEEEHHHHH	10.25	28285833
221	Phosphorylation	RKSELAATLGLSERQ HHHHHHHHHCCCHHH	18.76	26239621
225	Phosphorylation	LAATLGLSERQVKIW HHHHHCCCHHHHHHH	29.00	26239621
266	Phosphorylation	PQPPPQPSQPQPGAL CCCCCCCCCCCCCCC	49.60	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDX2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
60	S	Phosphorylation	Phosphorylation of Ser-60 mediates the transactivation capacity.	11729123

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDX2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLX5_MOUSE	Dlx5	physical	20211142
HLTF_MOUSE	Hltf	physical	20211142
ZN292_MOUSE	Zfp292	physical	20211142
PO5F1_MOUSE	Pou5f1	physical	16325584

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphorylation of the serine 60 residue within the Cdx2 activationdomain mediates its transactivation capacity.";
Rings E.H., Boudreau F., Taylor J.K., Moffett J., Suh E.R.,Traber P.G.;
Gastroenterology 121:1437-1450(2001).
Cited for: PHOSPHORYLATION AT SER-60.
PubMed: 11729123