HLTF_MOUSE - dbPTM
HLTF_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HLTF_MOUSE
UniProt AC Q6PCN7
Protein Name Helicase-like transcription factor
Gene Name Hltf
Organism Mus musculus (Mouse).
Sequence Length 1003
Subcellular Localization Cytoplasm. Nucleus . Nucleus, nucleolus. Nucleus, nucleoplasm. Nuclear localization is stimulated by progesterone..
Protein Description Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA (By similarity)..
Protein Sequence MSYTFTRGPVWKYSQSVQYGSHENIPRLSYSTFLPHFEFQDIIPPDDFLTSDEEQDLVLFGTMRGQVVGLRYYTGVVNNNEMVALQREPNNPYDKNAIKVNNVNGNQVGHIKREIAAAVAYIMDNKLAQVEGVVPFGASNTFTMPLYMTFWGKEENRNVVLEQLKKHGFKLGPTPKTLGSSLENAWGSGRAGPSYSRPAHVAVQMTTDQLKTEFDKLFEDLKEDDRTVEMEPAEAIETPLLPHQKQALAWMIARENSKELPPFWEQRNDLYYNTITNFSVKERPENVHGGILADDMGLGKTLTAIAVILTNFDDGRPLLSKRGKKNHPGKEYKDETIKRRGSNMDKKEDGHSESSTCGEEPSISGTPEKSSCTLSQLSSVCPKRRKISVQYIESSDSEEIETSELPQKMKGKLKNVQLNTKSRVKGSSKVKEDSKFALTFFASATQRKMLKKGMSMMECSEACDTGERTRATLIICPLSVLSNWIDQFGQHVKSEVHLNFYVYYGPDRIRDSAWLSKQDIILTTYNILTHDYGTKDDSPLHSIKWLRVILDEGHAIRNPNAQQTKAVLELEAERRWVLTGTPIQNSLKDLWSLLSFLKLKPFIDREWWYRIIQRPVTTGDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELPERKVFIQHITLSEEERKIYQSVKNEGKAAIGRYFTEGTVLAHYADVLGLLLRLRQICCHTHLLTNGMSSSGPSRSDTPEELRKMLIEKMKIILSSGSDEECAICLDSLTFPVITHCAHVFCKPCICQVIHSEQPHAKCPLCRNEIHGDNLLECPPEELACDSDKESSMEWKSSSKINALMHALIELRTKDPNIKSLVVSQFTTFLSLIETPLKASGFVFTRLDGSMAQKKRVESIQRFQNTEAGSPTIMLLSLKAGGVGLNLCAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKIQNTKRDLAAGAFGTKKTDANDMKQAKINEIRTLIDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationTRGPVWKYSQSVQYG
CCCCCEEEECCEECC		9.0225777480
14PhosphorylationRGPVWKYSQSVQYGS
CCCCEEEECCEECCC		16.5625777480
16PhosphorylationPVWKYSQSVQYGSHE
CCEEEECCEECCCCC		12.7823984901
19PhosphorylationKYSQSVQYGSHENIP
EEECCEECCCCCCCC		20.5924759943
21PhosphorylationSQSVQYGSHENIPRL
ECCEECCCCCCCCCC		23.7726824392
27MethylationGSHENIPRLSYSTFL
CCCCCCCCCCEECCC		32.25-
195PhosphorylationSGRAGPSYSRPAHVA
CCCCCCCCCCCCEEE		16.3121457752
352PhosphorylationDKKEDGHSESSTCGE
CCCCCCCCCCCCCCC		44.7125619855
354PhosphorylationKEDGHSESSTCGEEP
CCCCCCCCCCCCCCC		33.6825619855
355PhosphorylationEDGHSESSTCGEEPS
CCCCCCCCCCCCCCC		24.5425619855
356PhosphorylationDGHSESSTCGEEPSI
CCCCCCCCCCCCCCC		33.5325619855
362PhosphorylationSTCGEEPSISGTPEK
CCCCCCCCCCCCCCC		32.4425619855
364PhosphorylationCGEEPSISGTPEKSS
CCCCCCCCCCCCCCC		40.7425619855
366PhosphorylationEEPSISGTPEKSSCT
CCCCCCCCCCCCCCC		22.8325619855
373PhosphorylationTPEKSSCTLSQLSSV
CCCCCCCCHHHHHHH		31.2422942356
388PhosphorylationCPKRRKISVQYIESS
CCCCCEEEEEEECCC		13.2529550500
391PhosphorylationRRKISVQYIESSDSE
CCEEEEEEECCCCCC		12.4229550500
394PhosphorylationISVQYIESSDSEEIE
EEEEEECCCCCCCCC		29.8630352176
395PhosphorylationSVQYIESSDSEEIET
EEEEECCCCCCCCCC		32.1626643407
397PhosphorylationQYIESSDSEEIETSE
EEECCCCCCCCCCCC		38.7926643407
402PhosphorylationSDSEEIETSELPQKM
CCCCCCCCCCCCHHH		32.9129550500
434PhosphorylationSSKVKEDSKFALTFF
CCCCCCCCHHHHHHH		30.6623737553
455PhosphorylationKMLKKGMSMMECSEA
HHHHHCCCHHHHHHH		24.5224759943
629PhosphorylationGGLRRLQSLIKNITL
HHHHHHHHHHHHCEE		36.3317208939
672PhosphorylationSEEERKIYQSVKNEG
CHHHHHHHHHHHCCC		9.5826060331
674PhosphorylationEERKIYQSVKNEGKA
HHHHHHHHHHCCCCH		20.3526060331
686PhosphorylationGKAAIGRYFTEGTVL
CCHHHCCCCCCCCHH		15.0528285833
691PhosphorylationGRYFTEGTVLAHYAD
CCCCCCCCHHHHHHH		13.2028285833
696PhosphorylationEGTVLAHYADVLGLL
CCCHHHHHHHHHHHH		10.0128285833
730PhosphorylationSGPSRSDTPEELRKM
CCCCCCCCHHHHHHH		33.57-
898PhosphorylationFQNTEAGSPTIMLLS
HCCCCCCCCEEEEEE		26.3928059163
900PhosphorylationNTEAGSPTIMLLSLK
CCCCCCCEEEEEEEC		22.2528059163
982UbiquitinationAAGAFGTKKTDANDM
HHHCCCCCCCCHHHH		54.8022790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
195YPhosphorylationKinaseJAK2Q62120
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HLTF_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HLTF_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ANXA2_MOUSEAnxa2physical
23415230
S10AA_MOUSES100a10physical
23415230
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HLTF_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Mitochondrial phosphoproteome revealed by an improved IMAC method andMS/MS/MS.";
Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.;
Mol. Cell. Proteomics 6:669-676(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629, AND MASSSPECTROMETRY.

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