dbPTM

DLX2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DLX2_MOUSE
UniProt AC	P40764
Protein Name	Homeobox protein DLX-2
Gene Name	Dlx2
Organism	Mus musculus (Mouse).
Sequence Length	332
Subcellular Localization	Nucleus .
Protein Description	Acts as a transcriptional activator. [PubMed: 21875655 Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina]
Protein Sequence	MTGVFDSLVADMHSTQITASSTYHQHQQPPSGAGAGPGGNSNSSSSNSSLHKPQESPTLPVSTATDSSYYTNQQHPAGGGGGGASPYAHMGSYQYHASGLNNVSYSAKSSYDLGYTAAYTSYAPYGTSSSPVNNEPDKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPTEQHPGASASPPCASPPVSAPASWDFGAPQRMAGGGPGSGGGGAGSSGSSPSSAASAFLGNYPWYHQASGSASHLQATAPLLHPSQTPQAHHHHHHHHHAGGGAPVSAGTIF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	HQHQQPPSGAGAGPG CCCCCCCCCCCCCCC	48.21	-
45	Phosphorylation	GGNSNSSSSNSSLHK CCCCCCCCCCCCCCC	33.10	-
46	Phosphorylation	GNSNSSSSNSSLHKP CCCCCCCCCCCCCCC	42.55	-
49	Phosphorylation	NSSSSNSSLHKPQES CCCCCCCCCCCCCCC	38.45	-
235	Phosphorylation	SASPPCASPPVSAPA CCCCCCCCCCCCCCC	36.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DLX2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DLX2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DLX2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MSX1_MOUSE	Msx1	physical	20211142
SP7_MOUSE	Sp7	physical	20211142

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DLX2_MOUSE

Related Literatures of Post-Translational Modification