SP7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SP7_MOUSE
• UniProt AC: Q8VI67
• Protein Name: Transcription factor Sp7
• Gene Name: Sp7
• Organism: Mus musculus (Mouse).
• Sequence Length: 428
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences..
• Protein Sequence: MASSLLEEEAHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKGGTKKPYADLSAPKTMGDAYPAPFSSTNGLLSPAGSPPAPASGYANDYPPFPHSFPGPTGAQDPGLLVPKGHSSSDCLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLSTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQLEGSGAAKPPRGAGTGGSGGYAGSGAGRSTCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSVGEEEANQPPRSSTSPAPPEKAHGGSPEQSNLLEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	SSPLAMLTAACSKFG CCHHHHHHHHHHHHC	10.10	25159016
25	Phosphorylation	AMLTAACSKFGGSSP HHHHHHHHHHCCCCC	26.71	25159016
30	Phosphorylation	ACSKFGGSSPLRDST HHHHHCCCCCCCCCC	29.21	26160508
31	Phosphorylation	CSKFGGSSPLRDSTT HHHHCCCCCCCCCCC	31.09	26160508
36	Phosphorylation	GSSPLRDSTTLGKGG CCCCCCCCCCCCCCC	19.50	26160508
37	Phosphorylation	SSPLRDSTTLGKGGT CCCCCCCCCCCCCCC	30.26	26160508
38	Phosphorylation	SPLRDSTTLGKGGTK CCCCCCCCCCCCCCC	37.15	25159016
41	Propionylation	RDSTTLGKGGTKKPY CCCCCCCCCCCCCCC	58.23	30026585
45	Propionylation	TLGKGGTKKPYADLS CCCCCCCCCCCCCCC	55.83	30026585
55	Ubiquitination	YADLSAPKTMGDAYP CCCCCCCCCCCCCCC	51.35	-
73	Phosphorylation	SSTNGLLSPAGSPPA CCCCCCCCCCCCCCC	20.11	20682789
77	Phosphorylation	GLLSPAGSPPAPASG CCCCCCCCCCCCCCC	29.80	20682789
358	Propionylation	FTCLLCSKRFTRSDH EEEEEECCCCCCHHH	51.00	30026585
368	Propionylation	TRSDHLSKHQRTHGE CCHHHHHHHHHHCCC	50.55	30026585
386	Ubiquitination	GPPPSGPKELGEGRS CCCCCCCCCCCCCCC	69.92	-
405	Phosphorylation	EANQPPRSSTSPAPP HHCCCCCCCCCCCCC	43.68	26160508
406	Phosphorylation	ANQPPRSSTSPAPPE HCCCCCCCCCCCCCC	33.90	26160508
407	Phosphorylation	NQPPRSSTSPAPPEK CCCCCCCCCCCCCCH	39.72	26160508
408	Phosphorylation	QPPRSSTSPAPPEKA CCCCCCCCCCCCCHH	22.47	26160508
419	Phosphorylation	PEKAHGGSPEQSNLL CCHHCCCCHHHHHCC	29.83	25521595
423	Phosphorylation	HGGSPEQSNLLEI-- CCCCHHHHHCCCC--	27.99	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
73	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
77	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SP7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SP7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHIP_MOUSE	Stub1	physical	25818514

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.