RAB1A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB1A_RAT
• UniProt AC: Q6NYB7
• Protein Name: Ras-related protein Rab-1A
• Gene Name: Rab1A
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 205
• Subcellular Localization: Golgi apparatus . Endoplasmic reticulum . Early endosome . Cytoplasm, cytosol . Membrane . Melanosome . Alternates between membrane-associated and cytosolic forms.
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in anterograde melanosome transport (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes..
• Protein Sequence: MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSMNPEYD ------CCCCCHHHH	37.99	-
2	Phosphorylation	------MSSMNPEYD ------CCCCCHHHH	37.99	22673903
3	Phosphorylation	-----MSSMNPEYDY -----CCCCCHHHHH	22.68	23984901
8	Phosphorylation	MSSMNPEYDYLFKLL CCCCCHHHHHHHHHH	15.90	22673903
10	Phosphorylation	SMNPEYDYLFKLLLI CCCHHHHHHHHHHHH	17.09	-
35	Phosphorylation	LLRFADDTYTESYIS EEEECCCCCCHHHHH	32.65	22276854
36	Phosphorylation	LRFADDTYTESYIST EEECCCCCCHHHHHE	18.59	22276854
39	Phosphorylation	ADDTYTESYISTIGV CCCCCCHHHHHEEEC	21.70	22276854
40	Phosphorylation	DDTYTESYISTIGVD CCCCCHHHHHEEECC	7.83	22276854
58	Acetylation	RTIELDGKTIKLQIW EEEEECCEEEEEEEE	46.90	54411765
61	Ubiquitination	ELDGKTIKLQIWDTA EECCEEEEEEEECCC	39.30	-
61	Acetylation	ELDGKTIKLQIWDTA EECCEEEEEEEECCC	39.30	66736229
75	Phosphorylation	AGQERFRTITSSYYR CCHHHHHHHHHHHHC	26.37	28432305
77	Phosphorylation	QERFRTITSSYYRGA HHHHHHHHHHHHCCC	15.82	28432305
78	Phosphorylation	ERFRTITSSYYRGAH HHHHHHHHHHHCCCC	16.70	28432305
79	Other	RFRTITSSYYRGAHG HHHHHHHHHHCCCCE	19.96	-
79	O-(2-cholinephosphoryl)serine	RFRTITSSYYRGAHG HHHHHHHHHHCCCCE	19.96	-
79	Phosphorylation	RFRTITSSYYRGAHG HHHHHHHHHHCCCCE	19.96	28432305
112	Phosphorylation	WLQEIDRYASENVNK HHHHHHHHHCCCHHH	15.67	28551015
114	Phosphorylation	QEIDRYASENVNKLL HHHHHHHCCCHHHHH	22.29	28432305
132	Acetylation	KCDLTTKKVVDYTTA CCCCCCCCCCCHHHH	45.45	22902405
132	Succinylation	KCDLTTKKVVDYTTA CCCCCCCCCCCHHHH	45.45	26843850
136	Phosphorylation	TTKKVVDYTTAKEFA CCCCCCCHHHHHHHH	8.38	-
140	Acetylation	VVDYTTAKEFADSLG CCCHHHHHHHHHHHC	51.80	22902405
173	Acetylation	MTMAAEIKKRMGPGA HHHHHHHHHHHCCCC	26.32	72592355
188	Phosphorylation	TAGGAEKSNVKIQST CCCCCCCCCCEEECC	38.06	28432305
194	Phosphorylation	KSNVKIQSTPVKQSG CCCCEEECCCCCCCC	37.85	28432305
195	Phosphorylation	SNVKIQSTPVKQSGG CCCEEECCCCCCCCC	18.74	28432305
204	Geranylgeranylation	VKQSGGGCC------ CCCCCCCCC------	2.55	-
205	Geranylgeranylation	KQSGGGCC------- CCCCCCCC-------	7.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
194	S	Phosphorylation	Kinase	CDK1	P39951	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB1A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB1A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB1A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.