THOP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THOP1_RAT
• UniProt AC: P24155
• Protein Name: Thimet oligopeptidase
• Gene Name: Thop1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 687
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation..
• Protein Sequence: MKPPAACAGDVVDTVSPCSTVNHLRWDLSAQQIRALTTQLIEQTKCVYDRVGAQDFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPNKDIRAASTEADKKLSEFDVEMSMRQDVYQRVVWLQEKIPKDSLKPEAARYLERLIKLGRRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLNSLEKTEDGKLKVTLKYPHYFPLLKKCHVPETRRLLEEAFNCRCKEENCAILKELVSLRAQKSNLLGFRTHADYVLEMNMAKTSQTVATFLDELARKLKPLGEQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLAIYQELLGLTFTLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQLAIAAMVANFTKPTPDVPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLMRMSQHYRTGGEAPEDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDVDPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLSPKVGMDYRTSILRPGGSEDASTMLKQFLGRDPKQDAFLLSKGLQVEGCEPPAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	CAGDVVDTVSPCSTV CCCCEECCCCCCCCC	15.98	27097102
16	Phosphorylation	GDVVDTVSPCSTVNH CCEECCCCCCCCCCH	23.45	27097102
19	Phosphorylation	VDTVSPCSTVNHLRW ECCCCCCCCCCHHHC	38.48	27097102
20	Phosphorylation	DTVSPCSTVNHLRWD CCCCCCCCCCHHHCC	31.85	27097102
92	Acetylation	PQHVSPNKDIRAAST CCCCCCCCCHHHHCH	58.89	22902405
141	Phosphorylation	LKPEAARYLERLIKL CCHHHHHHHHHHHHH	14.27	-
172	Phosphorylation	KNIKKRLSLLCIDFN HHHHHHHHEEEEECC	24.27	23984901
220	Acetylation	GKLKVTLKYPHYFPL CCEEEEEECCCHHHH	47.58	22902405
229	Acetylation	PHYFPLLKKCHVPET CCHHHHHHHCCCHHH	62.12	22902405
257	Acetylation	EENCAILKELVSLRA HHHHHHHHHHHHHHH	42.78	22902405
278	Phosphorylation	GFRTHADYVLEMNMA CCCHHHHHHHHHHHH	14.02	-
538	Acetylation	APEDLLEKLIKSRQA CCHHHHHHHHHHCHH	56.32	22902405
634	Phosphorylation	FKQEGVLSPKVGMDY HHCCCCCCCCCCCCC	21.92	27097102
644	Phosphorylation	VGMDYRTSILRPGGS CCCCCCCCCCCCCCC	15.61	22817900
667	Acetylation	QFLGRDPKQDAFLLS HHHCCCCCCCHHHHC	66.16	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
644	S	Phosphorylation	Kinase	PKACA	P17612	PSP
644	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
644	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THOP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THOP1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of THOP1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.