GBB1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBB1_RAT
• UniProt AC: P54311
• Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
• Gene Name: Gnb1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 340
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction..
• Protein Sequence: MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSELDQLRQ ------CCHHHHHHH	47.03	-
2	Phosphorylation	------MSELDQLRQ ------CCHHHHHHH	47.03	26437020
15	Acetylation	RQEAEQLKNQIRDAR HHHHHHHHHHHHHHH	46.64	22902405
23	Ubiquitination	NQIRDARKACADATL HHHHHHHHHHHHCHH	49.92	-
29	Phosphorylation	RKACADATLSQITNN HHHHHHCHHHHHHHC	27.73	27097102
31	Phosphorylation	ACADATLSQITNNID HHHHCHHHHHHHCCC	18.38	27097102
34	Phosphorylation	DATLSQITNNIDPVG HCHHHHHHHCCCCCC	17.99	27097102
89	Acetylation	WDSYTTNKVHAIPLR EECCCCCEEEEEECC	33.05	22902405
111	Phosphorylation	AYAPSGNYVACGGLD EECCCCCEEEECCHH	7.92	-
136	Phosphorylation	REGNVRVSRELAGHT CCCCEEECHHHCCCC	14.96	29779826
266	Phosphorylation	QELMTYSHDNIICGI CCCEEECCCCEEEEE	23.02	-
289	Phosphorylation	GRLLLAGYDDFNCNV CCEEEEEECCCCCCH	13.51	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBB1_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
266	H	Phosphorylation	Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBB1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAC1A_RAT	Cacna1a	physical	15953418

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.