ALDR_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALDR_RAT
• UniProt AC: P07943
• Protein Name: Aldose reductase
• Gene Name: Akr1b1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 316
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies..
• Protein Sequence: MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASHLELNN ------CCCCEECCC	12.98	-
3	Phosphorylation	-----MASHLELNNG -----CCCCEECCCC	27.57	22673903
12	Acetylation	LELNNGTKMPTLGLG EECCCCCCCCCCCCC	44.26	22902405
22	Acetylation	TLGLGTWKSPPGQVT CCCCCCCCCCCCCHH	53.58	22902405
23	Phosphorylation	LGLGTWKSPPGQVTE CCCCCCCCCCCCHHH	28.08	22108457
53	Acetylation	AQVYQNEKEVGVALQ HHHHCCHHHHHHHHH	66.31	22902405
64	Acetylation	VALQEKLKEQVVKRQ HHHHHHHHHHHHHHH	58.11	22902405
69	Acetylation	KLKEQVVKRQDLFIV HHHHHHHHHHCCEEE	45.55	22902405
95	Acetylation	MVKGACQKTLSDLQL HHHHHHHHHHHHHCH	51.85	-
160	Phosphorylation	LVKAIGVSNFNPLQI CHHHHCCCCCCHHHH	30.41	22108457
173	Acetylation	QIERILNKPGLKYKP HHHHHHCCCCCCCCC	36.70	-
199	Phosphorylation	TQEKLIEYCHCKGIV CHHHHHHHHCCCEEE	4.78	14583551
222	Acetylation	SPDRPWAKPEDPSLL CCCCCCCCCCCCCHH	45.10	22902405
235	Acetylation	LLEDPRIKEIAAKYN HHCCHHHHHHHHHCC	44.33	-
240	Acetylation	RIKEIAAKYNKTTAQ HHHHHHHHCCCCCHH	40.09	22902405
263	Acetylation	RNLVVIPKSVTPARI CCEEEECCCCCHHHH	46.57	22902405
264	Phosphorylation	NLVVIPKSVTPARIA CEEEECCCCCHHHHH	26.35	23984901
266	Phosphorylation	VVIPKSVTPARIAEN EEECCCCCHHHHHHC	20.51	23984901
308	Acetylation	LMSCAKHKDYPFHAE HHHHHHCCCCCCCCC	59.24	72588593

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALDR_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALDR_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALDR_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ALDR_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.