| UniProt ID | GBP2_RAT | |
|---|---|---|
| UniProt AC | Q63663 | |
| Protein Name | Guanylate-binding protein 1 | |
| Gene Name | Gbp2 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 589 | |
| Subcellular Localization |
Cytoplasm . Cytoplasm, perinuclear region . Golgi apparatus membrane . Membrane Lipid-anchor . GBP2-GBP5 dimers localize to the Golgi apparatus. |
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| Protein Description | Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).. | |
| Protein Sequence | MASEIHMLQPMCLIENTEAHLVINQEALRILSAINQPVVVVAIVGLYRTGKSYLMNKLAGKRTGFSLGSTVQSHTKGIWMWCVPHPKKAGQTLVLLDTEGLEDVEKGDNQNDCWIFALAVLLSSTFVYNSMGTINQQAMDQLHYVTELTDLIKSKSSPDQSGIDDSANFVGFFPTFVWALRDFSLELEVNGKLVTPDEYLEHSLTLKKGADKKTKSFNEPRLCIRKFFPKRKCFIFDRPALRKQLCKLETLGEEELCSEFVEQVAEFTSYIFSYSAVKTLSGGIIVNGPRLKSLVQTYVGAISSGSLPCMESAVLTLAQIENSAAVQKAITHYEEQMNQKIQMPTETLQELLDLHRLIEREAIEIFLKNSFKDVDQKFQTELGNLLISKRDAFIKKNSDVSSAHCSDLIEDIFGPLEEEVKQGTFSKPGGYFLFLQMRQELEKKYNQAPGKGLEAEAVLKKYFESKEDIVETLLKTDQSLTEAAKEIEVERIKAETAEAANRELAEKQEKFELMMQQKEESYQEHVRQLTEKMKEEQKKLIEEQDNIIALKLREQEKFLREGYENESKKLLREIENMKRRQSPGKCTIL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 216 | Phosphorylation | GADKKTKSFNEPRLC CCCCCCCCCCCCCHH | 38.24 | 30181290 | |
| 372 | Acetylation | IFLKNSFKDVDQKFQ HHHHCCCCCCHHHHH | 57.58 | 73879475 | |
| 395 | Acetylation | SKRDAFIKKNSDVSS HHHHHHHHCCCCCCH | 39.17 | 26302492 | |
| 396 | Acetylation | KRDAFIKKNSDVSSA HHHHHHHCCCCCCHH | 57.79 | 26302492 | |
| 521 | Phosphorylation | MMQQKEESYQEHVRQ HHHHHHHHHHHHHHH | 32.96 | 30181290 | |
| 522 | Phosphorylation | MQQKEESYQEHVRQL HHHHHHHHHHHHHHH | 22.62 | 30181290 | |
| 586 | Geranylgeranylation | RRQSPGKCTIL---- HCCCCCCCCCC---- | 3.38 | 8148370 | |
| 586 | Geranylgeranylation | RRQSPGKCTIL---- HCCCCCCCCCC---- | 3.38 | 8148370 | |
| 586 | Methylation | RRQSPGKCTIL---- HCCCCCCCCCC---- | 3.38 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GBP2_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GBP2_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GBP2_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GBP2_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Prenylation | |
| Reference | PubMed |
| "Molecular cloning and characterization of an isoprenylated 67 kDaprotein."; Asundi V.K., Stahl R.C., Showalter L., Conner K.J., Carey D.J.; Biochim. Biophys. Acta 1217:257-265(1994). Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND ISOPRENYLATION ATCYS-586. | |
