IMPA1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMPA1_RAT
• UniProt AC: P97697
• Protein Name: Inositol monophosphatase 1
• Gene Name: Impa1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 277
• Subcellular Localization: Cytoplasm .
• Protein Description: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate..
• Protein Sequence: MADPWQECMDYAVILARQAGEMIREALKNKMDVMIKSSPADLVTVTDQKVEKMLMSSIKEKYPYHSFIGEESVASGEKTVFTEQPTWIIDPIDGTTNFVHRFPFVAVSIGFVVNKEMEFGVVYSCVEDKMYTGRKGKGAFCNGQKLRVSQQEDITKSLLVTELGSSRKPETLRIVLSNMERLCSIPIHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDMAGAGIIVIEAGGVLLDVTGGPFDLMSRRIIAASNIALAERIAKELEIIPLQRDDES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Acetylation	IREALKNKMDVMIKS HHHHHHCCCCEEEEC	34.58	22902405
37	Phosphorylation	KMDVMIKSSPADLVT CCCEEEECCCCCEEE	30.54	28432305
38	Phosphorylation	MDVMIKSSPADLVTV CCEEEECCCCCEEEE	21.07	28432305
49	Acetylation	LVTVTDQKVEKMLMS EEEECHHHHHHHHHH	55.99	22902405
52	Acetylation	VTDQKVEKMLMSSIK ECHHHHHHHHHHHHH	40.08	22902405
59	Acetylation	KMLMSSIKEKYPYHS HHHHHHHHHHCCCCC	50.53	22902405
62	Phosphorylation	MSSIKEKYPYHSFIG HHHHHHHCCCCCCCC	15.32	25575281
64	Phosphorylation	SIKEKYPYHSFIGEE HHHHHCCCCCCCCCC	13.65	25575281
66	Phosphorylation	KEKYPYHSFIGEESV HHHCCCCCCCCCCCC	16.83	25575281
72	Phosphorylation	HSFIGEESVASGEKT CCCCCCCCCCCCCCE	20.77	25575281
75	Phosphorylation	IGEESVASGEKTVFT CCCCCCCCCCCEEEE	45.38	25575281
145	Acetylation	GAFCNGQKLRVSQQE CCCCCCCCCEECCHH	39.39	22902405
156	Acetylation	SQQEDITKSLLVTEL CCHHHHHHHHHHHHC	39.17	22902405
161	Phosphorylation	ITKSLLVTELGSSRK HHHHHHHHHCCCCCC	26.01	30181290
165	Phosphorylation	LLVTELGSSRKPETL HHHHHCCCCCCCHHH	39.33	28432305
166	Phosphorylation	LVTELGSSRKPETLR HHHHCCCCCCCHHHH	42.39	28432305
264	Acetylation	ALAERIAKELEIIPL HHHHHHHHHCCCEEC	61.53	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMPA1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMPA1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMPA1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of IMPA1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.